Summary of chromogenic IHC
| MHCII status . | HLA-DR . | CD20 . | CD138 . | MUM1 . | Blimp1 . | XBP1s . |
|---|---|---|---|---|---|---|
| Overall (n = 40) | ||||||
| Range | 0.0-7.0 | 2.3-7.0 | 0.0-0.5 | 0.0-5.0 | 0.0-3.8 | 0.0-5.5 |
| Median | 5.0 | 6.0 | 0.0 | 2.3 | 0.7 | 2.2 |
| Mean | 4.4 | 5.8 | 0.0 | 2.4 | 0.9 | 2.0 |
| Low 10% (n = 2) | ||||||
| Range | NA | 6.0-6.3 | NA | 1.5-5.0 | 0.0-1.0 | NA |
| Median | 0.0 | 6.2 | 0.0 | 3.3 | 0.5 | 0.0 |
| Mean | 0.0 | 6.2 | 0.0 | 3.3 | 0.5 | 0.0 |
| 10%-25% (n = 6) | ||||||
| Range | 0.0-6.0 | 3.5-7.0 | NA | 2.0-5.0 | 0.0-2.5 | 0.8-5.5 |
| Median | 5.0 | 7.0 | 0.0 | 4.7 | 0.7 | 1.5 |
| Mean | 3.4 | 5.7 | 0.0 | 4.3 | 1.1 | 2.4 |
| 25%-50% (n = 7) | ||||||
| Range | 0.0-7.0 | 3.0-7.0 | NA | 0.0-5.0 | 0.7-3.8 | 0.0-4.7 |
| Median | 5.0 | 5.7 | 0.0 | 2.5 | 2.3 | 2.5 |
| Mean | 3.6 | 5.6 | 0.0 | 2.1 | 2.2 | 2.3 |
| Upper 50% (n = 25) | ||||||
| Range | 0.0-7.0 | 2.3-7.0 | 0.0-0.5 | 0.0-4.3 | 0.0-1.6 | 0.0-5.0 |
| Median | 5.7 | 6.0 | 0.0 | 2.2 | 0.4 | 2.2 |
| Mean | 5.2 | 5.9 | 0.0 | 2.0 | 0.6 | 2.0 |
| MHCII status . | HLA-DR . | CD20 . | CD138 . | MUM1 . | Blimp1 . | XBP1s . |
|---|---|---|---|---|---|---|
| Overall (n = 40) | ||||||
| Range | 0.0-7.0 | 2.3-7.0 | 0.0-0.5 | 0.0-5.0 | 0.0-3.8 | 0.0-5.5 |
| Median | 5.0 | 6.0 | 0.0 | 2.3 | 0.7 | 2.2 |
| Mean | 4.4 | 5.8 | 0.0 | 2.4 | 0.9 | 2.0 |
| Low 10% (n = 2) | ||||||
| Range | NA | 6.0-6.3 | NA | 1.5-5.0 | 0.0-1.0 | NA |
| Median | 0.0 | 6.2 | 0.0 | 3.3 | 0.5 | 0.0 |
| Mean | 0.0 | 6.2 | 0.0 | 3.3 | 0.5 | 0.0 |
| 10%-25% (n = 6) | ||||||
| Range | 0.0-6.0 | 3.5-7.0 | NA | 2.0-5.0 | 0.0-2.5 | 0.8-5.5 |
| Median | 5.0 | 7.0 | 0.0 | 4.7 | 0.7 | 1.5 |
| Mean | 3.4 | 5.7 | 0.0 | 4.3 | 1.1 | 2.4 |
| 25%-50% (n = 7) | ||||||
| Range | 0.0-7.0 | 3.0-7.0 | NA | 0.0-5.0 | 0.7-3.8 | 0.0-4.7 |
| Median | 5.0 | 5.7 | 0.0 | 2.5 | 2.3 | 2.5 |
| Mean | 3.6 | 5.6 | 0.0 | 2.1 | 2.2 | 2.3 |
| Upper 50% (n = 25) | ||||||
| Range | 0.0-7.0 | 2.3-7.0 | 0.0-0.5 | 0.0-4.3 | 0.0-1.6 | 0.0-5.0 |
| Median | 5.7 | 6.0 | 0.0 | 2.2 | 0.4 | 2.2 |
| Mean | 5.2 | 5.9 | 0.0 | 2.0 | 0.6 | 2.0 |
Data are overall range and averages for B-cell (CD20, HLA-DR) and plasma cell (CD138, MUM1, Blimp1, XBP1) markers in 40 cases of DLBCL as well as range and averages for DLBCL cases divided by MHC II status based on GEP.
NA indicates not applicable.