Incidence and severity of treatment-emergent AEs (≥ 25%) and carfilzomib-related AEs (N = 266)
| AE . | All grades,* n (%) . | Grades 3 or 4,* n (%) . | All grades carfilzomib-related,† n (%) . |
|---|---|---|---|
| Hematologic | |||
| Anemia | 122 (46) | 63 (24) | 59 (22) |
| Thrombocytopenia | 103 (39) | 77 (29) | 77 (29) |
| Lymphopenia | 62 (23) | 52 (20) | 44 (17) |
| Neutropenia | 48 (18) | 29 (11) | 40 (15) |
| Leukopenia | 37 (14) | 18 (6.8) | 31 (12) |
| Nonhematologic | |||
| Fatigue | 130 (49) | 20 (7.5) | 98 (37) |
| Nausea | 119 (45) | 5 (1.9) | 90 (34) |
| Dyspnea | 90 (34) | 9 (3.4) | 45 (17) |
| Diarrhea | 86 (32) | 2 (0.8) | 64 (24) |
| Pyrexia | 83 (31) | 4 (1.5) | 40 (15) |
| Headache | 74 (28) | 5 (1.9) | 46 (17) |
| Upper respiratory tract infection | 71 (27) | 12 (4.5) | 15 (5.6) |
| Increased serum creatinine | 67 (25) | 7 (2.6) | 44 (17) |
| Other events of clinical interest | |||
| Vomiting | 59 (22.2) | 2 (0.8) | 44 (16.5) |
| PN‡ | 33 (12.4) | 3 (1.1) | 22 (8.3) |
| Hypophosphatemia | 32 (12.0) | 16 (6.0) | 19 (7.1) |
| Pneumonia | 32 (12.0) | 25 (9.4) | 13 (4.9) |
| Hyponatremia | 31 (11.7) | 22 (8.3) | 13 (4.9) |
| Renal failure (acute) | 13 (4.9) | 9 (3.4) | 4 (1.5) |
| Febrile neutropenia | 2 (0.8) | 2 (0.8) | 2 (0.8) |
| Tumor lysis syndrome | 1 (0.4) | 0 (0) | 0 (0) |
| AE . | All grades,* n (%) . | Grades 3 or 4,* n (%) . | All grades carfilzomib-related,† n (%) . |
|---|---|---|---|
| Hematologic | |||
| Anemia | 122 (46) | 63 (24) | 59 (22) |
| Thrombocytopenia | 103 (39) | 77 (29) | 77 (29) |
| Lymphopenia | 62 (23) | 52 (20) | 44 (17) |
| Neutropenia | 48 (18) | 29 (11) | 40 (15) |
| Leukopenia | 37 (14) | 18 (6.8) | 31 (12) |
| Nonhematologic | |||
| Fatigue | 130 (49) | 20 (7.5) | 98 (37) |
| Nausea | 119 (45) | 5 (1.9) | 90 (34) |
| Dyspnea | 90 (34) | 9 (3.4) | 45 (17) |
| Diarrhea | 86 (32) | 2 (0.8) | 64 (24) |
| Pyrexia | 83 (31) | 4 (1.5) | 40 (15) |
| Headache | 74 (28) | 5 (1.9) | 46 (17) |
| Upper respiratory tract infection | 71 (27) | 12 (4.5) | 15 (5.6) |
| Increased serum creatinine | 67 (25) | 7 (2.6) | 44 (17) |
| Other events of clinical interest | |||
| Vomiting | 59 (22.2) | 2 (0.8) | 44 (16.5) |
| PN‡ | 33 (12.4) | 3 (1.1) | 22 (8.3) |
| Hypophosphatemia | 32 (12.0) | 16 (6.0) | 19 (7.1) |
| Pneumonia | 32 (12.0) | 25 (9.4) | 13 (4.9) |
| Hyponatremia | 31 (11.7) | 22 (8.3) | 13 (4.9) |
| Renal failure (acute) | 13 (4.9) | 9 (3.4) | 4 (1.5) |
| Febrile neutropenia | 2 (0.8) | 2 (0.8) | 2 (0.8) |
| Tumor lysis syndrome | 1 (0.4) | 0 (0) | 0 (0) |