Chromosomal abnormalities in addition to t(15;17) (ACAs) identified at diagnosis and relapse
| Patient no. . | ACA at diagnosis* . | ACA at relapse† . |
|---|---|---|
| 5 | None | t(3;11)(q28;q23), 10/19‡ |
| 6 | None | t(3;12)(p12;q24.3), 20/20 |
| 15 | None | t(4;5)(q21;q31), 4/4 |
| 9 | None | add(6)(q21), 2/2 |
| 12 | None | +8, 19/19 |
| 4 | None | i(8)(q10), 20/20 |
| 10 | None | Clone 1: add(22)(p11.2), 8/16; clone 2: idem,add(7)(q33), 2/16 |
| 1 | t(4;5)(q23;q31), 11/11ठ| t(4;5)(q23;q31); del(20)(q11.2q13.3), 3/3 |
| 7 | +8, 19/19 | +8, 9/9 |
| 8 | +8, 3/3 | +8; ?del(4)(q25),der(15)t(15;17)(q22;q21), −13, der(?16)t(13;16)(q12;q11), ider(17)(q10)t(15;17)(q22;q21), 1/1 |
| 20 | +8, 11/15 | +8, 20/20 |
| 3 | t(10;11)(q11.2;p11.2), 19/19§ | t(10;11)(q11.2;p11.2), 19/19 |
| 19 | der(15),ider(17)(q10) t(15;17)(q22;q21), 16/16 | der(15),ider(17)(q10) t(15;17)(q22;q21), 3/3 |
| 35 | add(8)(p23), 20/20 | Not available |
| 45 | +8, 20/20 | Not available |
| 43 | add(12)(p13), 19/19 | Not available |
| 40 | Clone 1: t(14;22)(p11.2;q11.2), 11/13; Clone 2: idem,ider(17)(q10) t(15;17)(q22;q21), 2/13 | Not available |
| Patient no. . | ACA at diagnosis* . | ACA at relapse† . |
|---|---|---|
| 5 | None | t(3;11)(q28;q23), 10/19‡ |
| 6 | None | t(3;12)(p12;q24.3), 20/20 |
| 15 | None | t(4;5)(q21;q31), 4/4 |
| 9 | None | add(6)(q21), 2/2 |
| 12 | None | +8, 19/19 |
| 4 | None | i(8)(q10), 20/20 |
| 10 | None | Clone 1: add(22)(p11.2), 8/16; clone 2: idem,add(7)(q33), 2/16 |
| 1 | t(4;5)(q23;q31), 11/11ठ| t(4;5)(q23;q31); del(20)(q11.2q13.3), 3/3 |
| 7 | +8, 19/19 | +8, 9/9 |
| 8 | +8, 3/3 | +8; ?del(4)(q25),der(15)t(15;17)(q22;q21), −13, der(?16)t(13;16)(q12;q11), ider(17)(q10)t(15;17)(q22;q21), 1/1 |
| 20 | +8, 11/15 | +8, 20/20 |
| 3 | t(10;11)(q11.2;p11.2), 19/19§ | t(10;11)(q11.2;p11.2), 19/19 |
| 19 | der(15),ider(17)(q10) t(15;17)(q22;q21), 16/16 | der(15),ider(17)(q10) t(15;17)(q22;q21), 3/3 |
| 35 | add(8)(p23), 20/20 | Not available |
| 45 | +8, 20/20 | Not available |
| 43 | add(12)(p13), 19/19 | Not available |
| 40 | Clone 1: t(14;22)(p11.2;q11.2), 11/13; Clone 2: idem,ider(17)(q10) t(15;17)(q22;q21), 2/13 | Not available |
Results from 39 cases analyzed at diagnosis; see supplemental Table 6 for complete karyotype information.
Results from 21 cases analyzed at relapse; see supplemental Table 5 for complete karyotype results.
Number of metaphase cells with ACA (numerator); total number of t(15;17)–positive metaphase cells (denominator); applies to all fractions in columns.
These translocations cannot represent constitutional rearrangements because normal karyotypes were also present.