Associations at diagnosis of patients with FLT3 mutations or ACAs by univariate and multivariate analyses
| Test parameter . | FLT3-ITD mutation . | FLT3-D835 mutation . | ACA . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Descriptor . | Univariate* . | Multivariate† . | Descriptor . | Univariate* . | Multivariate† . | Descriptor . | Univariate‡ . | Multivariate§ . | |
| Age | ANI | ANI | ANI | ANI | Older | ANI | .05 | ||
| Presenting WBC | High | .002 | .07 | High | ANI | .02 | — | ANI | ANI |
| Time to relapse | ANI | ANI | ANI | ANI | Longer | .03 | ANI | ||
| PML-RARα type | ↑ S-isoform incidence | < .001 | .04 | ↑ S-isoform incidence | ANI | .10 | — | ANI | ANI |
| FLT3-ITD+ | — | — | — | Negative associaton | ANI | .01 | — | ANI | ANI |
| FLT3-D835+ | Negative association | ANI | .06 | — | — | — | — | ANI | NE |
| Test parameter . | FLT3-ITD mutation . | FLT3-D835 mutation . | ACA . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Descriptor . | Univariate* . | Multivariate† . | Descriptor . | Univariate* . | Multivariate† . | Descriptor . | Univariate‡ . | Multivariate§ . | |
| Age | ANI | ANI | ANI | ANI | Older | ANI | .05 | ||
| Presenting WBC | High | .002 | .07 | High | ANI | .02 | — | ANI | ANI |
| Time to relapse | ANI | ANI | ANI | ANI | Longer | .03 | ANI | ||
| PML-RARα type | ↑ S-isoform incidence | < .001 | .04 | ↑ S-isoform incidence | ANI | .10 | — | ANI | ANI |
| FLT3-ITD+ | — | — | — | Negative associaton | ANI | .01 | — | ANI | ANI |
| FLT3-D835+ | Negative association | ANI | .06 | — | — | — | — | ANI | NE |
Data for all parameters are listed in “Statistical methods” by univariate and multivariate analysis in supplemental Tables 7 and 8. Descriptor indicates the nature of the association of the test parameter with the aberration in the heading.
ANI indicates association not indicated; —, not applicable; and NE, not evaluable.
Univariate analysis of FLT3 mutations had a sample size of n = 41, which differed by 1 case each for the FLT3-ITD and FLT3-D835 sets (see supplemental Table 6).
Multivariate analysis of FLT3 mutations had a sample size of n = 39.
Univariate analysis of ACA had a sample size of n = 39.
Multivariate analysis of ACA had a sample size of n = 35.