Table 8

Summary of genetic aberration associations

Overall associations 
    At diagnosis 
        FLT3-ITD+ with S-isoform, pWBChigh 
        FLT3-D835+ with pWBChigh 
        FLT3-ITD+ and FLT3-D835+ negatively 
    At relapse 
        FLT3-ITD+ with S-isoform, pWBChigh, ACA negatively 
        ACA with FLT3-ITD+ negatively, L-isoform, postrelapse death 
        PRα/LBD+ with pWBClow 
ATRA treatment stratified associations at relapse 
    Relapse On-ATRA 
        FLT3-ITD+ with S-isoform, PRα/LBD+ 
    Relapse Off-ATRA 
        FLT3-ITD+ with S-isoform, pWBChigh, ACA and PRα/LBD+ negatively 
        ACA with pWBClow, L-isoform, FLT3-ITD+ negatively 
        PRα/LBD+ with pWBClow, ACA, FLT3-ITD+ negatively 
Overall associations 
    At diagnosis 
        FLT3-ITD+ with S-isoform, pWBChigh 
        FLT3-D835+ with pWBChigh 
        FLT3-ITD+ and FLT3-D835+ negatively 
    At relapse 
        FLT3-ITD+ with S-isoform, pWBChigh, ACA negatively 
        ACA with FLT3-ITD+ negatively, L-isoform, postrelapse death 
        PRα/LBD+ with pWBClow 
ATRA treatment stratified associations at relapse 
    Relapse On-ATRA 
        FLT3-ITD+ with S-isoform, PRα/LBD+ 
    Relapse Off-ATRA 
        FLT3-ITD+ with S-isoform, pWBChigh, ACA and PRα/LBD+ negatively 
        ACA with pWBClow, L-isoform, FLT3-ITD+ negatively 
        PRα/LBD+ with pWBClow, ACA, FLT3-ITD+ negatively 
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