Relationship of genetic aberrations and recurrent subtype aberrations to postrelapse survival
| Parameter . | Nonsurvivors (n = 15) . | Survivors (n = 28) . | P . |
|---|---|---|---|
| Median postrelapse survival, d (range) | 368* (6-1104) | 1497* (371-3564) | < .001* |
| ACA, % positive | 100* (6) | 50* (12) | .05* |
| +8/i(8q), cases | 3 | 2 | — |
| Balanced translocation, cases | 2 | 3 | — |
| Complex karyotype, cases | 1 | 1 | — |
| PRα/LBD mutations, % positive | 40 | 39 | NS |
| Missense mutations, cases | 4 | 11 | NS |
| G289E/R, cases | 3* | 1* | — |
| R276Q/W, cases | 1 | 2 | — |
| Deletion mutations, cases | 2* | 0* | — |
| FLT3-ITD mutations, % positive | 21* | 46* (26) | .18 |
| FLT3-D835 mutations, % positive | 7 | 13 (24) | NS |
| Parameter . | Nonsurvivors (n = 15) . | Survivors (n = 28) . | P . |
|---|---|---|---|
| Median postrelapse survival, d (range) | 368* (6-1104) | 1497* (371-3564) | < .001* |
| ACA, % positive | 100* (6) | 50* (12) | .05* |
| +8/i(8q), cases | 3 | 2 | — |
| Balanced translocation, cases | 2 | 3 | — |
| Complex karyotype, cases | 1 | 1 | — |
| PRα/LBD mutations, % positive | 40 | 39 | NS |
| Missense mutations, cases | 4 | 11 | NS |
| G289E/R, cases | 3* | 1* | — |
| R276Q/W, cases | 1 | 2 | — |
| Deletion mutations, cases | 2* | 0* | — |
| FLT3-ITD mutations, % positive | 21* | 46* (26) | .18 |
| FLT3-D835 mutations, % positive | 7 | 13 (24) | NS |
Individual case data are detailed in supplemental Table 12. Numbers in brackets indicate the number of cases tested if less than total cases indicated by “n” in the NS corresponding column heading.
— indicates too few for analysis; and NS, no significant difference.
Distribution differences of possible interest between nonsurvivors and survivors.