Table 1 Clinical features of oral... | American Society of Hematology

Table 1

Clinical features of oral mucosal and salivary gland cGVHD

Oral mucosal cGVHD		Salivary gland cGVHD		Sclerotic cGVHD
Signs	Symptoms	Signs	Symptoms	Signs	Symptoms
Lichen-type features* Hyperkeratotic plaques* Erythema/atrophy† Ulcerations with pseudomembranes† Atrophic glossitis Superficial mucoceles†	Sensitivity to foods/drinks - Spicy/seasoned foods - Acidic foods (citrus, salad dressing, carbonated drinks) - Alcoholic beverages and alcohol containing mouth rinses - Salty foods - Hard/crunchy/crusty foods - Warm (temperature) foods/drinks Sensitivity to mint-flavored toothpaste/brushing Taste changes	Thickened, sticky, ropey or foamy saliva Lack of saliva/absence of floor of mouth pooling Atrophic mucosa Dental caries (interproximal and at the cervical margins) Oropharyngeal candidiasis Frequent water sipping Tongue “clicking” while speaking Food debris inside the mouth Inability to eat dry foods without fluids	Xerostomia† Sensitivity to foods/drinks Difficulty speaking Difficulty chewing Difficulty swallowing/throat constriction Waking at night because of severe dryness Taste changes	Restriction of mouth opening from sclerosis* Leathery skin Mucosal bands	Difficulty eating Jaw pain Tightness

Oral mucosal cGVHD		Salivary gland cGVHD		Sclerotic cGVHD
Signs	Symptoms	Signs	Symptoms	Signs	Symptoms
Lichen-type features* Hyperkeratotic plaques* Erythema/atrophy† Ulcerations with pseudomembranes† Atrophic glossitis Superficial mucoceles†	Sensitivity to foods/drinks - Spicy/seasoned foods - Acidic foods (citrus, salad dressing, carbonated drinks) - Alcoholic beverages and alcohol containing mouth rinses - Salty foods - Hard/crunchy/crusty foods - Warm (temperature) foods/drinks Sensitivity to mint-flavored toothpaste/brushing Taste changes	Thickened, sticky, ropey or foamy saliva Lack of saliva/absence of floor of mouth pooling Atrophic mucosa Dental caries (interproximal and at the cervical margins) Oropharyngeal candidiasis Frequent water sipping Tongue “clicking” while speaking Food debris inside the mouth Inability to eat dry foods without fluids	Xerostomia† Sensitivity to foods/drinks Difficulty speaking Difficulty chewing Difficulty swallowing/throat constriction Waking at night because of severe dryness Taste changes	Restriction of mouth opening from sclerosis* Leathery skin Mucosal bands	Difficulty eating Jaw pain Tightness

Consensus criteria diagnostic features.

Distinctive (supportive but nondiagnostic) features.