Genotype and allele frequencies of the A3669G SNP of GR in 499 patients with PMF and the healthy control populations
| . | N . | GR A3669G genotype, no. (%) . | Allele frequency, % . | ||||
|---|---|---|---|---|---|---|---|
| A/A . | A/G . | G/G . | A/G + G/G . | A . | G . | ||
| PMF patients | 499 | 274 (54.9) | 188 (37.7) | 37 (7.4) | 225 (45.1)* | 73.7 | 26.2† |
| Local controls | 111 | 73 (65.7) | 36 (32.4) | 2 (1.8) | 38 (34.2) | 81.98 | 18.02 |
| WTCCC controls | 2837 | 1997 (70.4) | 763 (26.9) | 77 (2.7) | 840 (29.6) | 83.8 | 16.2 |
| . | N . | GR A3669G genotype, no. (%) . | Allele frequency, % . | ||||
|---|---|---|---|---|---|---|---|
| A/A . | A/G . | G/G . | A/G + G/G . | A . | G . | ||
| PMF patients | 499 | 274 (54.9) | 188 (37.7) | 37 (7.4) | 225 (45.1)* | 73.7 | 26.2† |
| Local controls | 111 | 73 (65.7) | 36 (32.4) | 2 (1.8) | 38 (34.2) | 81.98 | 18.02 |
| WTCCC controls | 2837 | 1997 (70.4) | 763 (26.9) | 77 (2.7) | 840 (29.6) | 83.8 | 16.2 |
The A/G plus G/G genotype frequency was higher in patients with PMF with respect to local controls (P = .028) and WTCCC controls (P < .001)
The G allele frequency was statistically higher in PMF patients with respect to local controls (OR, 1.62; 95% CI, 1.12-2.35; P = .009) and WTCCC controls (OR, 1.84; 95% CI, 1.571-2.15; P < .001).