Clinical and laboratory features at diagnosis of patients with PMF stratified by the genotype of the A3669G polymorphism of the GR
| . | All patients . | GR A3669G genotype . | P . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| A/A . | A/G . | G/G . | A/A + A/G . | A/G + G/G . | A/A vs A/G . | A/A vs G/G . | A/G vs G/G . | A/A + A/G vs G/G . | A/A vs A/G + G/G . | ||
| N (%) | 499 | 274 (54.9) | 188 (37.7) | 37 (7.41) | 462 (92.6) | 225 (45.1) | |||||
| Male, no. (%) | 291 (58.3) | 160 (58.4) | 107 (56.9) | 24 (64.8) | 267 (57.8) | 131 (58.2) | .80 | .55 | .478 | .50 | .97 |
| Mean age at diagnosis, y (range) | 50.6 (6-82) | 50.7 (6-82) | 49.8 (6-82) | 53.3 (21-77) | 50.4 (6-82) | 50.4 (6-82) | .51 | .31 | .211 | .24 | .79 |
| Mean hemoglobin, g/L (range) | 12.5 (3-20.4) | 12.5 (3-20.4) | 12.4 (5.2-19.2) | 12.6 (7.9-17.3) | 12.5 (3-20.4) | 12.4 (5.2-19.2) | .71 | .85 | .704 | .78 | .79 |
| WBC count, × 109/L (range)* | 10.1 (1.8-64) | 9.8 (1.8-64) | 10.1 (1.9-50.9) | 12.2 (3.5-54) | 9.94 (1.8-64.3) | 10.4 (1.9-54) | .65 | .046 | .151 | .062 | .32 |
| Mean platelet count, × 109/L (range) | 504 (21-2926) | 520 (21-2926) | 463 (25-1488) | 591 (72-2000) | 497 (21-2926) | 484 (25-2000) | .09 | .31 | .058 | .13 | .27 |
| Mean spleen index, cm2 (range)† | 160 (70-1200) | 151 (70-850) | 173 (80-1200) | 168 (90-693) | 160 (70-1200) | 172 (80-1200) | .039 | .32 | .84 | .67 | .040 |
| Mean serum lactic dehydrogenase level, mU/mL (range) | N = 349 811 (120-2970) | N = 194 825 (120-2897) | N = 128 774 (156-2970) | N = 27 884 (203-2167) | N = 322 805 (120-2970) | N = 155 793 (156-2970) | .42 | .60 | .36 | .47 | .60 |
| Mean CD34-positive cells in PB, × 106/L (range) | N = 198 52.7 (0.75-1902) | N = 102 49.6 (0.75-1902) | N = 84 41.74 (0.81-682) | N = 12 155 (1-974) | N = 186 46.05 (0.75-1902) | N = 96 55.98 (0.81-9.74) | .73 | .09 | .007 | .030 | .79 |
| Mean serum cholesterol, mg/dL (range) | N = 226 156 (64-304) | N = 122 158 (64-272) | N = 84 153 (66-288) | N = 20 159 (88-304) | N = 206 156 (64-288) | N = 104 154 (66-304) | .36 | .93 | .58 | .758 | .46 |
| . | All patients . | GR A3669G genotype . | P . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| A/A . | A/G . | G/G . | A/A + A/G . | A/G + G/G . | A/A vs A/G . | A/A vs G/G . | A/G vs G/G . | A/A + A/G vs G/G . | A/A vs A/G + G/G . | ||
| N (%) | 499 | 274 (54.9) | 188 (37.7) | 37 (7.41) | 462 (92.6) | 225 (45.1) | |||||
| Male, no. (%) | 291 (58.3) | 160 (58.4) | 107 (56.9) | 24 (64.8) | 267 (57.8) | 131 (58.2) | .80 | .55 | .478 | .50 | .97 |
| Mean age at diagnosis, y (range) | 50.6 (6-82) | 50.7 (6-82) | 49.8 (6-82) | 53.3 (21-77) | 50.4 (6-82) | 50.4 (6-82) | .51 | .31 | .211 | .24 | .79 |
| Mean hemoglobin, g/L (range) | 12.5 (3-20.4) | 12.5 (3-20.4) | 12.4 (5.2-19.2) | 12.6 (7.9-17.3) | 12.5 (3-20.4) | 12.4 (5.2-19.2) | .71 | .85 | .704 | .78 | .79 |
| WBC count, × 109/L (range)* | 10.1 (1.8-64) | 9.8 (1.8-64) | 10.1 (1.9-50.9) | 12.2 (3.5-54) | 9.94 (1.8-64.3) | 10.4 (1.9-54) | .65 | .046 | .151 | .062 | .32 |
| Mean platelet count, × 109/L (range) | 504 (21-2926) | 520 (21-2926) | 463 (25-1488) | 591 (72-2000) | 497 (21-2926) | 484 (25-2000) | .09 | .31 | .058 | .13 | .27 |
| Mean spleen index, cm2 (range)† | 160 (70-1200) | 151 (70-850) | 173 (80-1200) | 168 (90-693) | 160 (70-1200) | 172 (80-1200) | .039 | .32 | .84 | .67 | .040 |
| Mean serum lactic dehydrogenase level, mU/mL (range) | N = 349 811 (120-2970) | N = 194 825 (120-2897) | N = 128 774 (156-2970) | N = 27 884 (203-2167) | N = 322 805 (120-2970) | N = 155 793 (156-2970) | .42 | .60 | .36 | .47 | .60 |
| Mean CD34-positive cells in PB, × 106/L (range) | N = 198 52.7 (0.75-1902) | N = 102 49.6 (0.75-1902) | N = 84 41.74 (0.81-682) | N = 12 155 (1-974) | N = 186 46.05 (0.75-1902) | N = 96 55.98 (0.81-9.74) | .73 | .09 | .007 | .030 | .79 |
| Mean serum cholesterol, mg/dL (range) | N = 226 156 (64-304) | N = 122 158 (64-272) | N = 84 153 (66-288) | N = 20 159 (88-304) | N = 206 156 (64-288) | N = 104 154 (66-304) | .36 | .93 | .58 | .758 | .46 |