Details of SRA seroconversion in 13 heparin reexposures performed for cardiac or vascular surgery
Patient . | Serotonin-release (%) at concentrations of UFH . | Platelet count decrease >30% or thrombosis on or after POD5 . | |||
---|---|---|---|---|---|
0 . | 0.1 . | 0.3 . | 100 . | ||
3 | 37 | 59 | 83 | 50 | No |
8 | 1 | 17 | 84 | 1 | No |
10 | 0 | 11 | 73 | 0 | No |
11 | 0 | 75 | 89 | 0 | No |
14 | 0 | 50 | 100 | 17 | No |
15 | 54 | 89 | 96 | 24 | No |
16 | 1 | 47 | 88 | 1 | No |
17 | 95 | 100 | 98 | 2 | HIT: 86% platelet decrease from 148 to 20 beginning on POD7 (Figure 4) |
22 | 4 (79*) | 82 | 89 | 1 | No; however, atrial fibrillation developed on POD14, and in vitro cross-reactivity (79% serotonin release) with danaparoid 0.3 anti-Xa U/mL was shown (Figure 4) |
Patient . | Serotonin-release (%) at concentrations of UFH . | Platelet count decrease >30% or thrombosis on or after POD5 . | |||
---|---|---|---|---|---|
0 . | 0.1 . | 0.3 . | 100 . | ||
3 | 37 | 59 | 83 | 50 | No |
8 | 1 | 17 | 84 | 1 | No |
10 | 0 | 11 | 73 | 0 | No |
11 | 0 | 75 | 89 | 0 | No |
14 | 0 | 50 | 100 | 17 | No |
15 | 54 | 89 | 96 | 24 | No |
16 | 1 | 47 | 88 | 1 | No |
17 | 95 | 100 | 98 | 2 | HIT: 86% platelet decrease from 148 to 20 beginning on POD7 (Figure 4) |
22 | 4 (79*) | 82 | 89 | 1 | No; however, atrial fibrillation developed on POD14, and in vitro cross-reactivity (79% serotonin release) with danaparoid 0.3 anti-Xa U/mL was shown (Figure 4) |
In vitro cross-reactivity (79% serotonin release) with danaparoid 0.3 anti-Xa U/mL was demonstrated (Figure 2).