Stroke (overt and silent) incidences in SCD
| Condition (setting) . | Incidence per 100 patient-years . | Reference . |
|---|---|---|
| Overt stroke | ||
| Overt stroke (CSSCD) | 0.61 | Ohene-Frempong et al, 199823 |
| 2-5 years old | 1.02 | |
| 5-9 years old | 0.79 | |
| Overt stroke after parvovirus infection | 30.1 | Wierenga et al, 200112 |
| Over stroke (California) | Fullerton et al, 200424 | |
| Before STOP | 0.88 | |
| After STOP | 0.17 | |
| Overt stroke (Memphis) | McCarville et al, 200825 | |
| Before TCD screening | 0.46 | |
| After TCD screening | 0.18 | |
| Over stroke (Philadelphia) | Enninful-Eghan et al, 20105 | |
| Before TCD screening | 0.67 | |
| After TCD screening | 0.06 | |
| Silent stroke | ||
| New silent stroke (CSSCD, well state) | 1.01 | Pegelow et al, 20023 |
| Recurrent silent stroke (CSSCD) | 7.06 | Pegelow et al, 20023 |
| Recurrent SCI (SITT, well state) | 10.7 | Quinn et al, 20107 |
| New ASCIE (SITT, well state) | 47.3 | Quinn et al, 20107 |
| ASCIE (in setting of severe anemia) | ||
| SCD patients | ∼ 664 | Current study |
| Non-SCD patients | ∼ 243 | Current study |
| All patients | ∼ 421 | Current study |
| Condition (setting) . | Incidence per 100 patient-years . | Reference . |
|---|---|---|
| Overt stroke | ||
| Overt stroke (CSSCD) | 0.61 | Ohene-Frempong et al, 199823 |
| 2-5 years old | 1.02 | |
| 5-9 years old | 0.79 | |
| Overt stroke after parvovirus infection | 30.1 | Wierenga et al, 200112 |
| Over stroke (California) | Fullerton et al, 200424 | |
| Before STOP | 0.88 | |
| After STOP | 0.17 | |
| Overt stroke (Memphis) | McCarville et al, 200825 | |
| Before TCD screening | 0.46 | |
| After TCD screening | 0.18 | |
| Over stroke (Philadelphia) | Enninful-Eghan et al, 20105 | |
| Before TCD screening | 0.67 | |
| After TCD screening | 0.06 | |
| Silent stroke | ||
| New silent stroke (CSSCD, well state) | 1.01 | Pegelow et al, 20023 |
| Recurrent silent stroke (CSSCD) | 7.06 | Pegelow et al, 20023 |
| Recurrent SCI (SITT, well state) | 10.7 | Quinn et al, 20107 |
| New ASCIE (SITT, well state) | 47.3 | Quinn et al, 20107 |
| ASCIE (in setting of severe anemia) | ||
| SCD patients | ∼ 664 | Current study |
| Non-SCD patients | ∼ 243 | Current study |
| All patients | ∼ 421 | Current study |
SCD indicates sickle cell disease; CSSCD, Cooperative Study of Sickle Cell Disease; STOP, Stroke Prevention Trial in Sickle Cell; TCD, transcranial doppler ultrasound; and SITT, Silent Infarction Transfusion Trial.