Major adverse effects of SMILE in 87 patients with NK/T-cell lymphoma
| . | No. of patients (%) . | All cases . | Newly diagnosed . | Relapsed/refractory . | P . |
|---|---|---|---|---|---|
| No. of SMILE cycles | |||||
| 0 | 1 (1) | ||||
| 1 | 5 (6) | ||||
| 2 | 21 (24) | ||||
| 3 | 21 (24) | ||||
| 4 | 13 (15) | ||||
| 5 | 3 (3) | ||||
| 6 | 23 (26) | ||||
| Adverse effect* | |||||
| Neutropenia | |||||
| Grade 1-2 | 28 (33) | 16 | 12 | ||
| Grade 3/4 | 58 (67) | 26 | 32 | .28 | |
| Thrombocytopenia | |||||
| Grade 1/2 | 50 (58) | 27 | 23 | ||
| Grade 3/4 | 36 (42) | 15 | 21 | .26 | |
| Hepatotoxicity | |||||
| Grade 1/2 | 52 (60) | 29 | 23 | ||
| Grade 3/4 | 6 (7) | 5 | 1 | .19 | |
| Nephrotoxicity | |||||
| Grade 1/2 | 14 (16) | 8 | 6 | ||
| Grade 3/4 | 1 (1) | 1 | 0 | .40 | |
| Allergy | |||||
| Grade 1/2 | 43 (49) | 16 | 27 | ||
| Grade 3/4 | 1 (1) | 1 | 0 | .20 | |
| Dose reduction | |||||
| Methotrexate | |||||
| 1 cycle | 3 (3) | ||||
| 2 cycles | 3 (3) | ||||
| 3 cycles | 5 (6) | ||||
| 4 cycles | 4 (5) | ||||
| Ifosfamide† | |||||
| 1 cycle | 3 (3) | ||||
| 3 cycles | 2 (2) | ||||
| l-Asparaginase | |||||
| 1 cycle | 7 (8) | ||||
| 2 cycles | 1 (1) | ||||
| 3 cycles2 | 3 (3) | ||||
| Prednisolone‡ | |||||
| 2 cycles | 1 (1) |
| . | No. of patients (%) . | All cases . | Newly diagnosed . | Relapsed/refractory . | P . |
|---|---|---|---|---|---|
| No. of SMILE cycles | |||||
| 0 | 1 (1) | ||||
| 1 | 5 (6) | ||||
| 2 | 21 (24) | ||||
| 3 | 21 (24) | ||||
| 4 | 13 (15) | ||||
| 5 | 3 (3) | ||||
| 6 | 23 (26) | ||||
| Adverse effect* | |||||
| Neutropenia | |||||
| Grade 1-2 | 28 (33) | 16 | 12 | ||
| Grade 3/4 | 58 (67) | 26 | 32 | .28 | |
| Thrombocytopenia | |||||
| Grade 1/2 | 50 (58) | 27 | 23 | ||
| Grade 3/4 | 36 (42) | 15 | 21 | .26 | |
| Hepatotoxicity | |||||
| Grade 1/2 | 52 (60) | 29 | 23 | ||
| Grade 3/4 | 6 (7) | 5 | 1 | .19 | |
| Nephrotoxicity | |||||
| Grade 1/2 | 14 (16) | 8 | 6 | ||
| Grade 3/4 | 1 (1) | 1 | 0 | .40 | |
| Allergy | |||||
| Grade 1/2 | 43 (49) | 16 | 27 | ||
| Grade 3/4 | 1 (1) | 1 | 0 | .20 | |
| Dose reduction | |||||
| Methotrexate | |||||
| 1 cycle | 3 (3) | ||||
| 2 cycles | 3 (3) | ||||
| 3 cycles | 5 (6) | ||||
| 4 cycles | 4 (5) | ||||
| Ifosfamide† | |||||
| 1 cycle | 3 (3) | ||||
| 3 cycles | 2 (2) | ||||
| l-Asparaginase | |||||
| 1 cycle | 7 (8) | ||||
| 2 cycles | 1 (1) | ||||
| 3 cycles2 | 3 (3) | ||||
| Prednisolone‡ | |||||
| 2 cycles | 1 (1) |