Univariate analyses of prognostic factors for remission after SMILE therapy
| Parameter . | Whole cohort (N = 87) . | Newly diagnosed patients (N = 43) . | Relapsed/refractory patients (N = 44) . | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Interim . | Completion . | Interim . | Completion . | Interim . | Completion . | |||||||||||||
| CR . | Non-CR . | P . | CR . | Non-CR . | P . | CR . | Non-CR . | P . | CR . | Non-CR . | P . | CR . | Non-CR . | P . | CR . | Non-CR . | P . | |
| Mean age, y* | 47.3 | 53.6 | .020 | 47.5 | 55.0 | .008 | 48.2 | 57.7 | .017 | 48.9 | 57.7 | .033 | 46.4 | 50.3 | .397 | 46.2 | 52.3 | .661 |
| Mean albumin, g/L* | 36.7 | 34.7 | .176 | 36.9 | 33.7 | .036 | 36.5 | 31.9 | .064 | 36.6 | 31.0 | .023 | 36.9 | 37.0 | .790 | 37.2 | 36.5 | .799 |
| Sex | ||||||||||||||||||
| Male | 39 | 20 | 45 | 14 | 18 | 7 | 19 | 6 | 21 | 13 | 26 | 8 | ||||||
| Female | 10 | 18 | .008 | 12 | 16 | .002 | 8 | 10 | .068 | 9 | 9 | .078 | 2 | 8 | .020 | 3 | 7 | .006 |
| Bone marrow | ||||||||||||||||||
| Not involved | 40 | 26 | 46 | 20 | 22 | 7 | 22 | 7 | 18 | 19 | 24 | 13 | ||||||
| Involved | 9 | 12 | .153 | 11 | 10 | .146 | 4 | 10 | .003 | 6 | 8 | .033 | 5 | 2 | .269 | 5 | 2 | .737 |
| PS | ||||||||||||||||||
| 0 | 33 | 23 | 41 | 15 | 19 | 7 | 22 | 4 | 14 | 16 | 19 | 11 | ||||||
| 1 | 8 | 13 | 8 | 13 | 2 | 9 | 1 | 10 | 6 | 4 | 7 | 3 | ||||||
| 2 | 8 | 2 | .072 | 8 | 2 | .009 | 5 | 1 | .004 | 5 | 1 | < .001 | 3 | 1 | .485 | 3 | 1 | .856 |
| Stage | ||||||||||||||||||
| I | 18 | 7 | 20 | 5 | 11 | 1 | 10 | 2 | 7 | 6 | 10 | 3 | ||||||
| II | 7 | 6 | 8 | 5 | 4 | 1 | 4 | 1 | 3 | 5 | 4 | 4 | ||||||
| III | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | ||||||
| IV | 22 | 25 | .121 | 27 | 20 | .185 | 11 | 15 | .010 | 14 | 12 | .158 | 11 | 10 | .468 | 13 | 8 | .426 |
| IPI | ||||||||||||||||||
| Low | 25 | 9 | 28 | 6 | 15 | 1 | 14 | 2 | 10 | 8 | 14 | 4 | ||||||
| Intermediate (L) | 9 | 7 | 10 | 6 | 3 | 4 | 4 | 3 | 6 | 3 | 6 | 3 | ||||||
| Intermediate (H) | 9 | 16 | 12 | 13 | 4 | 7 | 5 | 5 | 5 | 9 | 7 | 7 | ||||||
| High | 6 | 6 | .037 | 7 | 5 | .046 | 4 | 5 | .008 | 5 | 4 | .114 | 2 | 1 | .455 | 2 | 1 | .439 |
| KIPI | ||||||||||||||||||
| I | 12 | 8 | 15 | 5 | 9 | 1 | 9 | 1 | 3 | 7 | 6 | 4 | ||||||
| II | 16 | 1 | 16 | 1 | 6 | 1 | 6 | 1 | 10 | 0 | 10 | 0 | ||||||
| III | 6 | 7 | 6 | 7 | 3 | 1 | 2 | 2 | 3 | 6 | 4 | 5 | ||||||
| IV | 14 | 21 | .002 | 18 | 17 | .007 | 8 | 14 | .011 | 11 | 11 | .084 | 6 | 7 | .006 | 7 | 6 | .050 |
| Parameter . | Whole cohort (N = 87) . | Newly diagnosed patients (N = 43) . | Relapsed/refractory patients (N = 44) . | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Interim . | Completion . | Interim . | Completion . | Interim . | Completion . | |||||||||||||
| CR . | Non-CR . | P . | CR . | Non-CR . | P . | CR . | Non-CR . | P . | CR . | Non-CR . | P . | CR . | Non-CR . | P . | CR . | Non-CR . | P . | |
| Mean age, y* | 47.3 | 53.6 | .020 | 47.5 | 55.0 | .008 | 48.2 | 57.7 | .017 | 48.9 | 57.7 | .033 | 46.4 | 50.3 | .397 | 46.2 | 52.3 | .661 |
| Mean albumin, g/L* | 36.7 | 34.7 | .176 | 36.9 | 33.7 | .036 | 36.5 | 31.9 | .064 | 36.6 | 31.0 | .023 | 36.9 | 37.0 | .790 | 37.2 | 36.5 | .799 |
| Sex | ||||||||||||||||||
| Male | 39 | 20 | 45 | 14 | 18 | 7 | 19 | 6 | 21 | 13 | 26 | 8 | ||||||
| Female | 10 | 18 | .008 | 12 | 16 | .002 | 8 | 10 | .068 | 9 | 9 | .078 | 2 | 8 | .020 | 3 | 7 | .006 |
| Bone marrow | ||||||||||||||||||
| Not involved | 40 | 26 | 46 | 20 | 22 | 7 | 22 | 7 | 18 | 19 | 24 | 13 | ||||||
| Involved | 9 | 12 | .153 | 11 | 10 | .146 | 4 | 10 | .003 | 6 | 8 | .033 | 5 | 2 | .269 | 5 | 2 | .737 |
| PS | ||||||||||||||||||
| 0 | 33 | 23 | 41 | 15 | 19 | 7 | 22 | 4 | 14 | 16 | 19 | 11 | ||||||
| 1 | 8 | 13 | 8 | 13 | 2 | 9 | 1 | 10 | 6 | 4 | 7 | 3 | ||||||
| 2 | 8 | 2 | .072 | 8 | 2 | .009 | 5 | 1 | .004 | 5 | 1 | < .001 | 3 | 1 | .485 | 3 | 1 | .856 |
| Stage | ||||||||||||||||||
| I | 18 | 7 | 20 | 5 | 11 | 1 | 10 | 2 | 7 | 6 | 10 | 3 | ||||||
| II | 7 | 6 | 8 | 5 | 4 | 1 | 4 | 1 | 3 | 5 | 4 | 4 | ||||||
| III | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | ||||||
| IV | 22 | 25 | .121 | 27 | 20 | .185 | 11 | 15 | .010 | 14 | 12 | .158 | 11 | 10 | .468 | 13 | 8 | .426 |
| IPI | ||||||||||||||||||
| Low | 25 | 9 | 28 | 6 | 15 | 1 | 14 | 2 | 10 | 8 | 14 | 4 | ||||||
| Intermediate (L) | 9 | 7 | 10 | 6 | 3 | 4 | 4 | 3 | 6 | 3 | 6 | 3 | ||||||
| Intermediate (H) | 9 | 16 | 12 | 13 | 4 | 7 | 5 | 5 | 5 | 9 | 7 | 7 | ||||||
| High | 6 | 6 | .037 | 7 | 5 | .046 | 4 | 5 | .008 | 5 | 4 | .114 | 2 | 1 | .455 | 2 | 1 | .439 |
| KIPI | ||||||||||||||||||
| I | 12 | 8 | 15 | 5 | 9 | 1 | 9 | 1 | 3 | 7 | 6 | 4 | ||||||
| II | 16 | 1 | 16 | 1 | 6 | 1 | 6 | 1 | 10 | 0 | 10 | 0 | ||||||
| III | 6 | 7 | 6 | 7 | 3 | 1 | 2 | 2 | 3 | 6 | 4 | 5 | ||||||
| IV | 14 | 21 | .002 | 18 | 17 | .007 | 8 | 14 | .011 | 11 | 11 | .084 | 6 | 7 | .006 | 7 | 6 | .050 |
PS indicates performance score; L, low; H, high; and KIPI, Korean IPI.
P values obtained by Student t test; all other P values were obtained by χ2 test.