Conditioning regimens of NF-08-TM
| Conditioning . | Cy (mg/kg/d), d −10 to −9 . | IV Busulfex (mg/kg/d),* d −8 to −6 . | Thiotepa (mg/kg/d bid), d −5 . | Fludarabine (mg/m2/d), d −8 to −4 . |
|---|---|---|---|---|
| Regimen for group I | 60 | 5 | 40 | |
| 1-2 y | 4.4 | |||
| > 2 y | 4.0 | |||
| Regimen for group II | 55 | 5 | 40 | |
| < 6 y | 3.6 | |||
| > 6 y | 3.2 | |||
| Regimen for group III | 50 | 5 | 40 | |
| < 8 y | 3.0 | |||
| > 8 y | 2.8 |
| Conditioning . | Cy (mg/kg/d), d −10 to −9 . | IV Busulfex (mg/kg/d),* d −8 to −6 . | Thiotepa (mg/kg/d bid), d −5 . | Fludarabine (mg/m2/d), d −8 to −4 . |
|---|---|---|---|---|
| Regimen for group I | 60 | 5 | 40 | |
| 1-2 y | 4.4 | |||
| > 2 y | 4.0 | |||
| Regimen for group II | 55 | 5 | 40 | |
| < 6 y | 3.6 | |||
| > 6 y | 3.2 | |||
| Regimen for group III | 50 | 5 | 40 | |
| < 8 y | 3.0 | |||
| > 8 y | 2.8 |
Average plasma Css of busulfan was tested on day −8 and targeted to range between 300 and 600 μg/L. The dose of busulfan was increased or decreased by 1.2 mg/kg when Css was < 300 μg/L or > 600 μg/L and was given in divided doses on day −6.