Associations between chromosomal or gene alterations, baseline characteristics, and treatment response
| Parameter . | Age . | Binet C vs A/B . | Unmut. IGHV . | ZAP70 ≥20% . | CD38 ≥30% . | β2M >3.5 mg/L . | Del(11q)* . | Del(13q)* . | Del(17p)* . | Tri(12)* . | Chromosomal translocations . | Complex karyotypes . | Nonresponse to therapy . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATMmut | ∅ | ∅ | .002↑ | ∅ | ∅ | ∅ | <.001↑ | ∅ | ∅ | .045↓ | .014↑ | ∅ | ∅ |
| BIRC3mut | .044↓ | .048↓ | ∅ | ∅ | ∅ | ∅ | (.070)↑ | ∅ | ∅ | <.001↑ | ∅ | ∅ | ∅ |
| BRAFmut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | .030↑ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| CHD2mut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| DDX3Xmut | ∅ | ∅ | ∅ | (.079)↑ | ∅ | (.069)↑ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| FAT1mut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| FBXW7mut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | (.098)↓ | ∅ | .017↑ | ∅ | .025↑ | ∅ |
| KRASmut | ∅ | ∅ | .014↑ | .021↑ | .005↑ | ∅ | ∅ | (.098)↓ | ∅ | ∅ | (.058)↓ | ∅ | .015↑ |
| MYD88mut | (.066)↓ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| NFKBIEmut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | .013↑ | (.057)↑ | ∅ | ∅ | ∅ | ∅ | ∅ |
| NOTCH1mut | (.057)↑ | ∅ | <.001↑ | <.001↑ | .006↑ | .025↑ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| PIK3CGmut | (.097)↑ | (.067)↓ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| POT1mut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | .039↓ | ∅ | (.074)↓ | ∅ |
| SAMHD1mut | ∅ | ∅ | ∅ | (.086)↑ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| SF3B1mut | ∅ | ∅ | ∅ | .024↑ | .009↑ | ∅ | ∅ | (.088)↓ | ∅ | ∅ | .037↓ | ∅ | ∅ |
| TP53mut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | <.001↑ | .012↓ | (.072)↑ | .011↑ | .001↑ |
| XPO1mut | .040↓ | ∅ | .030↑ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| Chromosomal translocations | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | .002↑ | ∅ | NA | <.001↑ | ∅ |
| Complex karyotypes | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | <.001↑ | ∅ | <.001↑ | NA | ∅ |
| Nonresponse to therapy | ∅ | ∅ | .007↑ | ∅ | ∅ | ∅ | ∅ | ∅ | .004↑ | ∅ | ∅ | ∅ | NA |
| Parameter . | Age . | Binet C vs A/B . | Unmut. IGHV . | ZAP70 ≥20% . | CD38 ≥30% . | β2M >3.5 mg/L . | Del(11q)* . | Del(13q)* . | Del(17p)* . | Tri(12)* . | Chromosomal translocations . | Complex karyotypes . | Nonresponse to therapy . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATMmut | ∅ | ∅ | .002↑ | ∅ | ∅ | ∅ | <.001↑ | ∅ | ∅ | .045↓ | .014↑ | ∅ | ∅ |
| BIRC3mut | .044↓ | .048↓ | ∅ | ∅ | ∅ | ∅ | (.070)↑ | ∅ | ∅ | <.001↑ | ∅ | ∅ | ∅ |
| BRAFmut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | .030↑ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| CHD2mut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| DDX3Xmut | ∅ | ∅ | ∅ | (.079)↑ | ∅ | (.069)↑ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| FAT1mut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| FBXW7mut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | (.098)↓ | ∅ | .017↑ | ∅ | .025↑ | ∅ |
| KRASmut | ∅ | ∅ | .014↑ | .021↑ | .005↑ | ∅ | ∅ | (.098)↓ | ∅ | ∅ | (.058)↓ | ∅ | .015↑ |
| MYD88mut | (.066)↓ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| NFKBIEmut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | .013↑ | (.057)↑ | ∅ | ∅ | ∅ | ∅ | ∅ |
| NOTCH1mut | (.057)↑ | ∅ | <.001↑ | <.001↑ | .006↑ | .025↑ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| PIK3CGmut | (.097)↑ | (.067)↓ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| POT1mut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | .039↓ | ∅ | (.074)↓ | ∅ |
| SAMHD1mut | ∅ | ∅ | ∅ | (.086)↑ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| SF3B1mut | ∅ | ∅ | ∅ | .024↑ | .009↑ | ∅ | ∅ | (.088)↓ | ∅ | ∅ | .037↓ | ∅ | ∅ |
| TP53mut | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | <.001↑ | .012↓ | (.072)↑ | .011↑ | .001↑ |
| XPO1mut | .040↓ | ∅ | .030↑ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ |
| Chromosomal translocations | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | .002↑ | ∅ | NA | <.001↑ | ∅ |
| Complex karyotypes | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | ∅ | <.001↑ | ∅ | <.001↑ | NA | ∅ |
| Nonresponse to therapy | ∅ | ∅ | .007↑ | ∅ | ∅ | ∅ | ∅ | ∅ | .004↑ | ∅ | ∅ | ∅ | NA |
Serum TK levels >10 U/L were not significantly associated with any mutation or chromosomal translocations/complex karyotypes and are therefore not included in this overview.
Arrows, direction of the association, eg, BIRC3 mutations are decreased in patients with higher median age; mut, mutation; NA, not applicable; ∅, absence of a statistically significant association (P < .05) or trend (P < .10; in parentheses) per χ2, Fisher’s exact test, or logistic regression (for nonresponse).
Detected by FISH.