Prognostic factors associated with PFS and OS in multivariate models
| Variable . | HR . | 95% CI . | P value . | |
|---|---|---|---|---|
| Lower . | Upper . | |||
| Multivariate Cox regression for PFS | ||||
| Clb-R vs Clb | 0.385 | 0.217 | 0.684 | .001 |
| Clb-G vs Clb | 0.149 | 0.081 | 0.274 | <.001 |
| Unmutated IGHV | 3.278 | 2.081 | 5.163 | <.001 |
| Del(17p) and/or TP53mut | 3.079 | 1.550 | 6.116 | .001 |
| Multivariate Cox regression for OS | ||||
| β2M >3.5 mg/L | 1.879 | 1.020 | 3.459 | .043 |
| Complex karyotypes | 2.682 | 1.366 | 5.264 | .004 |
| Unmutated IGHV | 3.061 | 1.482 | 6.321 | .003 |
| POT1mut | 3.997 | 1.581 | 10.106 | .003 |
| Binet C vs A/B | 4.251 | 2.193 | 8.240 | <.001 |
| Variable . | HR . | 95% CI . | P value . | |
|---|---|---|---|---|
| Lower . | Upper . | |||
| Multivariate Cox regression for PFS | ||||
| Clb-R vs Clb | 0.385 | 0.217 | 0.684 | .001 |
| Clb-G vs Clb | 0.149 | 0.081 | 0.274 | <.001 |
| Unmutated IGHV | 3.278 | 2.081 | 5.163 | <.001 |
| Del(17p) and/or TP53mut | 3.079 | 1.550 | 6.116 | .001 |
| Multivariate Cox regression for OS | ||||
| β2M >3.5 mg/L | 1.879 | 1.020 | 3.459 | .043 |
| Complex karyotypes | 2.682 | 1.366 | 5.264 | .004 |
| Unmutated IGHV | 3.061 | 1.482 | 6.321 | .003 |
| POT1mut | 3.997 | 1.581 | 10.106 | .003 |
| Binet C vs A/B | 4.251 | 2.193 | 8.240 | <.001 |
The table lists independent variables associated with time-to-event outcome (PFS or OS) in multivariate analysis. Briefly, all parameters with a univariate P < .10 in univariate analysis (supplemental Table 3) were entered into multivariate Cox proportional hazards models to identify variables with significant and independent prognostic value.