Biologic characteristics of clinical complications
| Clinical manifestations . | No. . | Hb, mean ± SD . | % HbF, mean ± SD . | LDH, mean ± SD . | D50, mean ± SD . | % DRBCs, mean ± SD . |
|---|---|---|---|---|---|---|
| Total | 500 | 8.8 ± 1.2 | 7.3 ± 5.3 | 375 ± 133 | 1.096 ± 0.003 | 12.7 ± 7.8 |
| Skin ulcers | 34 | 8.2 ± 0.9*† | 6.4 ± 5.9 | 414 ± 163 | 1.096 ± 0.003 | 16.4 ± 8.5†‡ |
| Pulmonary hypertension | 11 | 7.9 ± 1.7‡§ | 8.3 ± 4.7 | 490 ± 182‡§ | 1.096 ± 0.003 | 14.3 ± 7 |
| Priapism | 33 | 9.2 ± 1.4 | 6.8 ± 6.7 | 382 ± 144 | 1.096 ± 0.003 | 15.7 ± 6.9‡§ |
| Renal dysfunction | 49 | 7.9 ± 2.9*† | 7.5 ± 6 | 440 ± 161*§ | 1.096 ± 0.003 | 16.3 ± 6.9*† |
| Stroke | 22 | 8.3 ± 1§ | 6.7 ± 6.2 | 446 ± 147§ | 1.095 ± 0.003 | 12 ± 6.4 |
| None of the above | 100 | 8.9 ± 1.1 | 7 ± 4.5 | 375 ± 141 | 1.095 ± 0.004 | 11.3 ± 8.6 |
| Osteonecrosis | 81 | 9 ± 1.3 | 7.9 ± 5.3 | 367 ± 126 | 1.095 ± 0.003 | 12.3 ± 7.6 |
| Retinal complication | 151 | 8.7 ± 2.4 | 6.8 ± 4.9 | 383 ± 128 | 1.095 ± 0.003 | 13.3 ± 7.8 |
| Cholecystectomy | 113 | 8.6 ± 1.2§ | 6.6 ± 4.8 | 411 ± 160‡ | 1.095 ± 0.003 | 14.3 ± 8.2§ |
| ACS during 1 y | 34 | 8.2 ± 3.2§ | 8 ± 4.4 | 423 ± 132 | 1.095 ± 0.002 | 13.3 ± 6.6§ |
| VOC during 1 y | 81 | 8.9 ± 1.4 | 8.3 ± 5.4 | 378 ± 124 | 1.095 ± 0.003 | 12.3 ± 7.6 |
| Clinical manifestations . | No. . | Hb, mean ± SD . | % HbF, mean ± SD . | LDH, mean ± SD . | D50, mean ± SD . | % DRBCs, mean ± SD . |
|---|---|---|---|---|---|---|
| Total | 500 | 8.8 ± 1.2 | 7.3 ± 5.3 | 375 ± 133 | 1.096 ± 0.003 | 12.7 ± 7.8 |
| Skin ulcers | 34 | 8.2 ± 0.9*† | 6.4 ± 5.9 | 414 ± 163 | 1.096 ± 0.003 | 16.4 ± 8.5†‡ |
| Pulmonary hypertension | 11 | 7.9 ± 1.7‡§ | 8.3 ± 4.7 | 490 ± 182‡§ | 1.096 ± 0.003 | 14.3 ± 7 |
| Priapism | 33 | 9.2 ± 1.4 | 6.8 ± 6.7 | 382 ± 144 | 1.096 ± 0.003 | 15.7 ± 6.9‡§ |
| Renal dysfunction | 49 | 7.9 ± 2.9*† | 7.5 ± 6 | 440 ± 161*§ | 1.096 ± 0.003 | 16.3 ± 6.9*† |
| Stroke | 22 | 8.3 ± 1§ | 6.7 ± 6.2 | 446 ± 147§ | 1.095 ± 0.003 | 12 ± 6.4 |
| None of the above | 100 | 8.9 ± 1.1 | 7 ± 4.5 | 375 ± 141 | 1.095 ± 0.004 | 11.3 ± 8.6 |
| Osteonecrosis | 81 | 9 ± 1.3 | 7.9 ± 5.3 | 367 ± 126 | 1.095 ± 0.003 | 12.3 ± 7.6 |
| Retinal complication | 151 | 8.7 ± 2.4 | 6.8 ± 4.9 | 383 ± 128 | 1.095 ± 0.003 | 13.3 ± 7.8 |
| Cholecystectomy | 113 | 8.6 ± 1.2§ | 6.6 ± 4.8 | 411 ± 160‡ | 1.095 ± 0.003 | 14.3 ± 8.2§ |
| ACS during 1 y | 34 | 8.2 ± 3.2§ | 8 ± 4.4 | 423 ± 132 | 1.095 ± 0.002 | 13.3 ± 6.6§ |
| VOC during 1 y | 81 | 8.9 ± 1.4 | 8.3 ± 5.4 | 378 ± 124 | 1.095 ± 0.003 | 12.3 ± 7.6 |
Significant differences between the means sharing the same character compared with total, P < .005.
Significant differences between the means sharing the same character compared with none of the above, P < .005.
Significant differences between the means sharing the same character compared with total, P < .05.
Significant differences between the means sharing the same character compared with none of the above, P < .05.