Association between HLA-DPA1 and DPB1 phenotypes and risk of childhood ALL, NCCLS, 1995-2008
| . | Non-Hispanic white . | Hispanic . | Pooled OR (95% CI)† . | Phom . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases . | Controls . | OR (95% CI)† . | Cases . | Controls . | OR (95% CI)† . | |||||||
| n* . | % . | n* . | % . | n* . | % . | n* . | % . | |||||
| DPA1 phenotypes‡ | ||||||||||||
| 01:03 | 251 | 94.7 | 391 | 95.8 | 0.76 (0.37-1.57) | 301 | 94.4 | 418 | 95.4 | 0.80 (0.41-1.54) | 0.78 (0.48-1.27) | .918 |
| 02:01 | 73 | 27.5 | 101 | 24.8 | 1.19 (0.83-1.69) | 86 | 27.0 | 125 | 28.5 | 0.93 (0.67-1.28) | 1.04 (0.82-1.31) | .315 |
| 02:02 | 18 | 6.8 | 29 | 7.1 | 0.94 (0.51-1.72) | 44 | 13.8 | 44 | 10.1 | 1.43 (0.92-2.24) | 1.24 (0.86-1.77) | .275 |
| n | 265 | 408 | 319 | 438 | ||||||||
| DPB1 phenotypes‡ | ||||||||||||
| 01:01 | 31 | 11.7 | 35 | 8.6 | 1.44 (0.86-2.41) | 35 | 10.9 | 35 | 8.0 | 1.42 (0.87-2.33) | 1.43 (1.01-2.04) | .969 |
| 02:01 | 64 | 24.2 | 108 | 26.5 | 0.88 (0.62-1.26) | 72 | 22.5 | 92 | 20.9 | 1.10 (0.78-1.56) | 0.99 (0.77-1.27) | .378 |
| 03:01 | 52 | 19.6 | 79 | 19.4 | 1.01 (0.68-1.49) | 34 | 10.6 | 56 | 12.7 | 0.81 (0.52-1.28) | 0.92 (0.68-1.23) | .469 |
| 04:01 | 161 | 60.8 | 269 | 65.9 | 0.80 (0.58-1.10) | 133 | 41.6 | 193 | 43.9 | 0.91 (0.68-1.22) | 0.84 (0.68-1.05) | .560 |
| 04:02 | 58 | 21.9 | 89 | 21.8 | 1.00 (0.69-1.45) | 174 | 54.4 | 242 | 55.0 | 0.97 (0.73-1.30) | 1.00 (0.79-1.26) | .895 |
| 05:01 | 10 | 3.8 | 17 | 4.2 | 0.89 (0.40-1.98) | 20 | 6.3 | 23 | 5.2 | 1.21 (0.65-2.25) | 1.08 (0.66-1.75) | .552 |
| 11:01 | 10 | 3.8 | 21 | 5.1 | 0.74 (0.34-1.59) | 11 | 3.4 | 17 | 3.9 | 0.89 (0.41-1.92) | 0.81 (0.47-1.40) | .740 |
| 14:01 | 6 | 2.3 | 5 | 1.2 | 1.90 (0.57-6.34) | 20 | 6.3 | 24 | 5.5 | 1.16 (0.63-2.13) | 1.27 (0.73-2.18) | .474 |
| 17:01 | 10 | 3.8 | 12 | 2.9 | 1.33 (0.56-3.13) | 20 | 6.3 | 24 | 5.5 | 1.16 (0.63-2.14) | 1.18 (0.72-1.95) | .800 |
| n | 265 | 408 | 320 | 440 | ||||||||
| . | Non-Hispanic white . | Hispanic . | Pooled OR (95% CI)† . | Phom . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases . | Controls . | OR (95% CI)† . | Cases . | Controls . | OR (95% CI)† . | |||||||
| n* . | % . | n* . | % . | n* . | % . | n* . | % . | |||||
| DPA1 phenotypes‡ | ||||||||||||
| 01:03 | 251 | 94.7 | 391 | 95.8 | 0.76 (0.37-1.57) | 301 | 94.4 | 418 | 95.4 | 0.80 (0.41-1.54) | 0.78 (0.48-1.27) | .918 |
| 02:01 | 73 | 27.5 | 101 | 24.8 | 1.19 (0.83-1.69) | 86 | 27.0 | 125 | 28.5 | 0.93 (0.67-1.28) | 1.04 (0.82-1.31) | .315 |
| 02:02 | 18 | 6.8 | 29 | 7.1 | 0.94 (0.51-1.72) | 44 | 13.8 | 44 | 10.1 | 1.43 (0.92-2.24) | 1.24 (0.86-1.77) | .275 |
| n | 265 | 408 | 319 | 438 | ||||||||
| DPB1 phenotypes‡ | ||||||||||||
| 01:01 | 31 | 11.7 | 35 | 8.6 | 1.44 (0.86-2.41) | 35 | 10.9 | 35 | 8.0 | 1.42 (0.87-2.33) | 1.43 (1.01-2.04) | .969 |
| 02:01 | 64 | 24.2 | 108 | 26.5 | 0.88 (0.62-1.26) | 72 | 22.5 | 92 | 20.9 | 1.10 (0.78-1.56) | 0.99 (0.77-1.27) | .378 |
| 03:01 | 52 | 19.6 | 79 | 19.4 | 1.01 (0.68-1.49) | 34 | 10.6 | 56 | 12.7 | 0.81 (0.52-1.28) | 0.92 (0.68-1.23) | .469 |
| 04:01 | 161 | 60.8 | 269 | 65.9 | 0.80 (0.58-1.10) | 133 | 41.6 | 193 | 43.9 | 0.91 (0.68-1.22) | 0.84 (0.68-1.05) | .560 |
| 04:02 | 58 | 21.9 | 89 | 21.8 | 1.00 (0.69-1.45) | 174 | 54.4 | 242 | 55.0 | 0.97 (0.73-1.30) | 1.00 (0.79-1.26) | .895 |
| 05:01 | 10 | 3.8 | 17 | 4.2 | 0.89 (0.40-1.98) | 20 | 6.3 | 23 | 5.2 | 1.21 (0.65-2.25) | 1.08 (0.66-1.75) | .552 |
| 11:01 | 10 | 3.8 | 21 | 5.1 | 0.74 (0.34-1.59) | 11 | 3.4 | 17 | 3.9 | 0.89 (0.41-1.92) | 0.81 (0.47-1.40) | .740 |
| 14:01 | 6 | 2.3 | 5 | 1.2 | 1.90 (0.57-6.34) | 20 | 6.3 | 24 | 5.5 | 1.16 (0.63-2.13) | 1.27 (0.73-2.18) | .474 |
| 17:01 | 10 | 3.8 | 12 | 2.9 | 1.33 (0.56-3.13) | 20 | 6.3 | 24 | 5.5 | 1.16 (0.63-2.14) | 1.18 (0.72-1.95) | .800 |
| n | 265 | 408 | 320 | 440 | ||||||||
Number and percent of subjects typing for each allele.
ORs and 95% CIs were calculated using logistic regression adjusting for child's age and sex. The pooled analysis additionally adjusted for race/ethnicity, and the P value (Phom) for the χ2 test of homogeneity in risk estimates between non-Hispanic whites and Hispanics are shown.
HLA-DPA1 and DPB1 alleles < 0.05 phenotype frequency not shown. Includes DPA1, 01:04, 03:01, and 04:01; and DPB1, 02:02, 102:01, 06:01, 09:01, 10:01, 13:01, 15:01, 16:01, 18:01, 26:01, 29:01, 34:01, 40:01, 51:01, 54:01, and 60:01.