Pretreatment clinical and laboratory data
| Parameter . | G6PD-normal males (n = 806) . | Hemizygous G6PD-deficient males (n = 122) . | G6PD-normal females (n = 636) . | Heterozygous females (n = 236) . | Homozygous G6PD-deficient females (n = 30) . | All subjects (n = 1830) . |
|---|---|---|---|---|---|---|
| Age, y | 4.4 ± 3.1 | 4.3 ± 3.2 | 4.6 ± 3.2 | 4.2 ± 3.1 | 3.9 ± 3.1 | 4.4 ± 3.1 |
| Temperature, °C | 37.88 ± 0.99 | 37.75 ± 0.94 | 37.90 ± 0.96 | 37.81 ± 0.96 | 38.05 ± 0.91 | 37.87 ± 0.97 |
| Parasitemia, μL−1 | 52 516 (216-323 361) | 65 220 (1626-705 600) | 56 722 (185-389 415) | 53 429 (484-303 400) | 48 452 (1026-211 546) | 54 876 (185-705 600) |
| Hemoglobin, g/dL | 10.00 ± 1.57 | 9.94 ± 1.59 | 10.19 ± 1.56 | 9.94 ± 1.36 | 9.47 ± 1.64 | 10.05 ± 1.55 |
| Hematocrit, % | 30.5 ± 4.3 | 30.2 ± 4.6 | 31.0 ± 4.4 | 30.2 ± 3.8 | 29.0 ± 4.1 | 30.6 ± 4.3 |
| Reticulocytes, % | 1.4 ± 1.6 | 1.5 ± 1.4 | 1.5 ± 1.9 | 1.4 ± 1.2 | 1.7 ± 1.4 | 1.5 ± 1.7 |
| WBC ×109/L | 9.6 ± 4.0 | 9.8 ± 4.3 | 9.6 ± 4.0 | 9.7 ± 3.8 | 9.0 ± 4.3 | 9.6 ± 4.0 |
| Unconj bil, μmol/L | 10.1 ± 11.1 | 11.5 ± 13.1 | 10.8 ± 10.5 | 12.3 ± 19.1 | 11.3 ± 8.8 | 10.7 ± 12.4 |
| Platelets × 109/L | 197.0 ± 109.3 | 195.6 ± 88.9 | 199.3 ± 119.8 | 189.4 ± 98.6 | 216.4 ± 134.1 | 197.0 ± 111.0 |
| ALT, IU/L | 26.1 ± 20.7 | 33.8 ± 82.7 | 31.8 ± 42.1 | 29.0 ± 32.2 | 26.2 ± 18.1 | 29.0 ± 37.6 |
| AST, IU/L | 44.7 ± 32.3 | 52.4 ± 80.5 | 47.6 ± 44.6 | 43.8 ± 33.3 | 44.0 ± 23.8 | 46.1 ± 41.8 |
| Dapsone group, n | 631 | 95 | 514 | 200 | 24 | 1464 |
| AL group, n | 175 | 27 | 122 | 36 | 6 | 366 |
| Parameter . | G6PD-normal males (n = 806) . | Hemizygous G6PD-deficient males (n = 122) . | G6PD-normal females (n = 636) . | Heterozygous females (n = 236) . | Homozygous G6PD-deficient females (n = 30) . | All subjects (n = 1830) . |
|---|---|---|---|---|---|---|
| Age, y | 4.4 ± 3.1 | 4.3 ± 3.2 | 4.6 ± 3.2 | 4.2 ± 3.1 | 3.9 ± 3.1 | 4.4 ± 3.1 |
| Temperature, °C | 37.88 ± 0.99 | 37.75 ± 0.94 | 37.90 ± 0.96 | 37.81 ± 0.96 | 38.05 ± 0.91 | 37.87 ± 0.97 |
| Parasitemia, μL−1 | 52 516 (216-323 361) | 65 220 (1626-705 600) | 56 722 (185-389 415) | 53 429 (484-303 400) | 48 452 (1026-211 546) | 54 876 (185-705 600) |
| Hemoglobin, g/dL | 10.00 ± 1.57 | 9.94 ± 1.59 | 10.19 ± 1.56 | 9.94 ± 1.36 | 9.47 ± 1.64 | 10.05 ± 1.55 |
| Hematocrit, % | 30.5 ± 4.3 | 30.2 ± 4.6 | 31.0 ± 4.4 | 30.2 ± 3.8 | 29.0 ± 4.1 | 30.6 ± 4.3 |
| Reticulocytes, % | 1.4 ± 1.6 | 1.5 ± 1.4 | 1.5 ± 1.9 | 1.4 ± 1.2 | 1.7 ± 1.4 | 1.5 ± 1.7 |
| WBC ×109/L | 9.6 ± 4.0 | 9.8 ± 4.3 | 9.6 ± 4.0 | 9.7 ± 3.8 | 9.0 ± 4.3 | 9.6 ± 4.0 |
| Unconj bil, μmol/L | 10.1 ± 11.1 | 11.5 ± 13.1 | 10.8 ± 10.5 | 12.3 ± 19.1 | 11.3 ± 8.8 | 10.7 ± 12.4 |
| Platelets × 109/L | 197.0 ± 109.3 | 195.6 ± 88.9 | 199.3 ± 119.8 | 189.4 ± 98.6 | 216.4 ± 134.1 | 197.0 ± 111.0 |
| ALT, IU/L | 26.1 ± 20.7 | 33.8 ± 82.7 | 31.8 ± 42.1 | 29.0 ± 32.2 | 26.2 ± 18.1 | 29.0 ± 37.6 |
| AST, IU/L | 44.7 ± 32.3 | 52.4 ± 80.5 | 47.6 ± 44.6 | 43.8 ± 33.3 | 44.0 ± 23.8 | 46.1 ± 41.8 |
| Dapsone group, n | 631 | 95 | 514 | 200 | 24 | 1464 |
| AL group, n | 175 | 27 | 122 | 36 | 6 | 366 |
AL indicates artemether-lumefantrine; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Unconj bil, unconjugated bilirubin; and WBC, white blood cell.
All baseline and laboratory values are mean ± SD except for parasitemia which is mean (range).