Characteristics of eligible studies
| Reference . | Setting (n) . | Patient characteristics . | Prevalence . | Reference standard . | ||
|---|---|---|---|---|---|---|
| Population (%) . | Median age, y . | No. (%) female . | ||||
| Lillo-Le Louët et al17 | France (84) | CV surgery (100) | 67 | 37 (44) | 0.42 | 1. Platelet count recovery within 5 days of heparin cessation AND |
| 2. SRA > 20% OR no other explanation for thrombocytopenia | ||||||
| Lo et al14 | Canada (100) | CV surgery (50) ICU (10) | 68 | 38 (38) | 0.16 | 1. Positive polyspecific EIA AND |
| Medical (20) Non-CV surgery (20) | 2. SRA > 50% (IgG-specific EIA > 1.0 OD units if SRA indeterminate) | |||||
| Lo et al14 | Germany (236) | CV surgery (18) ICU (20) | 55 | 106 (45) | 0.08 | 1. Positive polyspecific EIA AND |
| Medical (47) | 2. HIPA | |||||
| Non-CV surgery (15) | ||||||
| Pouplard et al18 | France (213) | CV surgery (14) | 69 | 73 (34) | 0.10 | SRA > 20% |
| Medical (42) | ||||||
| Non-CV surgery (19) | ||||||
| NR (25) | ||||||
| Bryant et al19 | Australia (246) | CV surgery (43) | 62 | 92 (37) | 0.04 | SRA > 20% |
| Medical (49) | ||||||
| Non-CV surgery (8) | ||||||
| Denys et al23 | Belgium (102) | CV surgery (51) | 70.5 | 45 (44) | 0.10 | Flow cytometric assay for CD62p |
| Medical (42) | ||||||
| Non-CV surgery (9) | ||||||
| Bakchoul et al20 | Germany (500) | NR | NR | NR | 0.07 | HIPA |
| Crowther et al24 | Canada (49) | Medical ICU (90) | 65 | 24 (49) | 0.04 | SRA > 50% |
| Surgical ICU (10) | ||||||
| Cuker et al10 | United States (50) | CV surgery (46) | 65 | 30 (60) | 0.14 | Consensus diagnosis of expert panel |
| Medical (40) | ||||||
| Non-CV surgery (14) | ||||||
| Berry et al25 | United States (104) | CV surgery (46) | 60 | 37 (36) | 0.19 | SRA > 20% |
| Non-CV surgery (54) | ||||||
| Nellen et al21 | Switzerland (1291) | CV surgery (7) | 68 | 566 (44) | 0.07 | PAT |
| ICU (20) | ||||||
| Medical (54) | ||||||
| Non-CV surgery (16) | ||||||
| Other (3) | ||||||
| Tawfik et al22 | Egypt (50) | Medical (40) CV surgery (36) | 64 | 19 (38) | 0.10 | 1. SRA > 2 SD above negative control AND |
| Non-CV surgery (24) | 2. Clinical course after HIT laboratory testing consistent with HIT | |||||
| Demma et al26 | United States (43) | CV surgery (100) | 65 | 20 (47) | 0.26 | SRA ≥ 20% |
| Reference . | Setting (n) . | Patient characteristics . | Prevalence . | Reference standard . | ||
|---|---|---|---|---|---|---|
| Population (%) . | Median age, y . | No. (%) female . | ||||
| Lillo-Le Louët et al17 | France (84) | CV surgery (100) | 67 | 37 (44) | 0.42 | 1. Platelet count recovery within 5 days of heparin cessation AND |
| 2. SRA > 20% OR no other explanation for thrombocytopenia | ||||||
| Lo et al14 | Canada (100) | CV surgery (50) ICU (10) | 68 | 38 (38) | 0.16 | 1. Positive polyspecific EIA AND |
| Medical (20) Non-CV surgery (20) | 2. SRA > 50% (IgG-specific EIA > 1.0 OD units if SRA indeterminate) | |||||
| Lo et al14 | Germany (236) | CV surgery (18) ICU (20) | 55 | 106 (45) | 0.08 | 1. Positive polyspecific EIA AND |
| Medical (47) | 2. HIPA | |||||
| Non-CV surgery (15) | ||||||
| Pouplard et al18 | France (213) | CV surgery (14) | 69 | 73 (34) | 0.10 | SRA > 20% |
| Medical (42) | ||||||
| Non-CV surgery (19) | ||||||
| NR (25) | ||||||
| Bryant et al19 | Australia (246) | CV surgery (43) | 62 | 92 (37) | 0.04 | SRA > 20% |
| Medical (49) | ||||||
| Non-CV surgery (8) | ||||||
| Denys et al23 | Belgium (102) | CV surgery (51) | 70.5 | 45 (44) | 0.10 | Flow cytometric assay for CD62p |
| Medical (42) | ||||||
| Non-CV surgery (9) | ||||||
| Bakchoul et al20 | Germany (500) | NR | NR | NR | 0.07 | HIPA |
| Crowther et al24 | Canada (49) | Medical ICU (90) | 65 | 24 (49) | 0.04 | SRA > 50% |
| Surgical ICU (10) | ||||||
| Cuker et al10 | United States (50) | CV surgery (46) | 65 | 30 (60) | 0.14 | Consensus diagnosis of expert panel |
| Medical (40) | ||||||
| Non-CV surgery (14) | ||||||
| Berry et al25 | United States (104) | CV surgery (46) | 60 | 37 (36) | 0.19 | SRA > 20% |
| Non-CV surgery (54) | ||||||
| Nellen et al21 | Switzerland (1291) | CV surgery (7) | 68 | 566 (44) | 0.07 | PAT |
| ICU (20) | ||||||
| Medical (54) | ||||||
| Non-CV surgery (16) | ||||||
| Other (3) | ||||||
| Tawfik et al22 | Egypt (50) | Medical (40) CV surgery (36) | 64 | 19 (38) | 0.10 | 1. SRA > 2 SD above negative control AND |
| Non-CV surgery (24) | 2. Clinical course after HIT laboratory testing consistent with HIT | |||||
| Demma et al26 | United States (43) | CV surgery (100) | 65 | 20 (47) | 0.26 | SRA ≥ 20% |
ICU indicates intensive care unit; NR, not reported; EIA, enzyme immunoassay; HIPA, heparin–induced platelet activation assay; and PAT, heparin-induced platelet aggregation test.