Correlation of pSTAT3 and Myc expression by IHC with clinicopathologic characteristics of DLBCL patients treated on the N0489 ER-CHOP clinical trial
| Parameter . | pSTAT3 IHC . | c-Myc IHC . | ||||||
|---|---|---|---|---|---|---|---|---|
| DLBCL (n = 40) . | STAT3− (n = 26), n (%) . | STAT3+ (n = 14), n (%) . | P . | DLBCL (n = 24), n (%) . | cMyc− (n = 12), n (%) . | cMyc+ (n = 12), n (%) . | P . | |
| Age ≥ 60 y | 17 (43) | 12 (46) | 5 (36) | .52 | 10 (42) | 5 (42) | 5 (42) | 1.00 |
| B symptoms present | 20 (50) | 14 (54) | 6 (43) | .51 | 14 (58) | 7 (58) | 7 (58) | 1.00 |
| Elevated LDH | 30 (75) | 23 (88) | 7 (50) | .007 | 18 (75) | 10 (83) | 8 (67) | .35 |
| Performance status ≥ 2 | 5 (13) | 3 (12) | 2 (14) | .80 | 4 (17) | 2 (17) | 2 (17) | 1.00 |
| EN sites ≥ 2 | 7 (18) | 5 (19) | 2 (14) | .69 | 4 (17) | 3 (25) | 1 (8) | |
| Stage III/IV | 31 (78) | 20 (77) | 11 (79) | .91 | 18 (75) | 9 (75) | 9 (75) | 1.00 |
| Bulky disease ≥ 10 cm | 6 (15) | 5 (19) | 1 (7) | .31 | 5 (21) | 4 (33) | 1 (8) | .13 |
| IPI 0-2 | 24 (60) | 15 (58) | 9 (64) | .68 | 14 (58) | 7 (58) | 7 (58) | 1.00 |
| IPI 3-5 | 16 (40) | 11 (42) | 5 (36) | 10 (42) | 5 (42) | 5 (42) | ||
| Parameter . | pSTAT3 IHC . | c-Myc IHC . | ||||||
|---|---|---|---|---|---|---|---|---|
| DLBCL (n = 40) . | STAT3− (n = 26), n (%) . | STAT3+ (n = 14), n (%) . | P . | DLBCL (n = 24), n (%) . | cMyc− (n = 12), n (%) . | cMyc+ (n = 12), n (%) . | P . | |
| Age ≥ 60 y | 17 (43) | 12 (46) | 5 (36) | .52 | 10 (42) | 5 (42) | 5 (42) | 1.00 |
| B symptoms present | 20 (50) | 14 (54) | 6 (43) | .51 | 14 (58) | 7 (58) | 7 (58) | 1.00 |
| Elevated LDH | 30 (75) | 23 (88) | 7 (50) | .007 | 18 (75) | 10 (83) | 8 (67) | .35 |
| Performance status ≥ 2 | 5 (13) | 3 (12) | 2 (14) | .80 | 4 (17) | 2 (17) | 2 (17) | 1.00 |
| EN sites ≥ 2 | 7 (18) | 5 (19) | 2 (14) | .69 | 4 (17) | 3 (25) | 1 (8) | |
| Stage III/IV | 31 (78) | 20 (77) | 11 (79) | .91 | 18 (75) | 9 (75) | 9 (75) | 1.00 |
| Bulky disease ≥ 10 cm | 6 (15) | 5 (19) | 1 (7) | .31 | 5 (21) | 4 (33) | 1 (8) | .13 |
| IPI 0-2 | 24 (60) | 15 (58) | 9 (64) | .68 | 14 (58) | 7 (58) | 7 (58) | 1.00 |
| IPI 3-5 | 16 (40) | 11 (42) | 5 (36) | 10 (42) | 5 (42) | 5 (42) | ||