Comparison of PSMB SNP allelic frequencies in pretreatment (n = 47) and posttreatment (n = 29) samples from MM patients with population frequency data (European, whenever available) from the National Center for Biotechnology Information (NCBI) SNP database
| Gene . | SNP ID . | Amino acids . | Alleles . | NCBI frequency . | Observed frequency . | FDR P . |
|---|---|---|---|---|---|---|
| Pretreatment samples | ||||||
| PSMB1 | rs12717 | P11A | C/G | 0.61/0.39 | 0.58/0.42 | .813 |
| PSMB5 | rs11543947 | R24C | C/T | NA* | 0.95/0.05 | NA |
| PSMB6 | rs3169950 | A21A | G/A | 0.57/0.43 | 0.67/0.33 | .386 |
| rs11552523 | T56T | T/C | 0.99/0.02† | 0.98/0.02 | > .999 | |
| rs2304974 | P107A | C/G | 0.91/0.09† | 0.94/0.06 | .746 | |
| rs2304975 | S115S | C/T | 0.64/0.36† | 0.77/0.23 | .081 | |
| rs7468 | Y177Y | C/T | 0.91/0.09‡ | 0.93/0.07 | .740 | |
| PSMB8 | rs17220206 | S70T | T/A | 0.97/0.03† | 1.00/0.00 | .573 |
| PSMB9 | rs35100697 | G9E | G/A | 0.97/0.03† | 1.00/0.00 | > .999 |
| rs241419 | V32I | G/A | 0.99/0.01 | 0.98/0.02 | .777 | |
| rs17587 | R60H | G/A | 0.70/0.30 | 0.77/0.23 | .635 | |
| rs20547 | A161A | A/G | 0.99/0.01 | 0.94/0.06 | .081 | |
| rs17213861 | R173C | C/T | 0.98/0.02† | 1.00/0.00 | .740 | |
| PSMB10 | rs20549 | L107L | T/C | 0.83/0.17 | 0.72/0.28 | .168 |
| rs14178 | G151G | T/C | 0.95/0.05 | 0.87/0.13 | .057 | |
| Posttreatment samples | ||||||
| PSMB1 | rs12717 | P11A | C/G | 0.61/0.39 | 0.63/0.38 | > .999 |
| PSMB5 | rs11543947 | R24C | C/T | NA* | 0.83/0.17 | NA |
| PSMB6 | rs3169950 | A21A | G/A | 0.57/0.43 | 0.41/0.59 | .499 |
| rs11552523 | T56T | T/C | 0.99/0.02† | 0.97/0.03 | .701 | |
| rs2304974 | P107A | C/G | 0.91/0.09† | 0.97/0.03 | .701 | |
| rs2304975 | S115S | C/T | 0.64/0.36† | 0.97/0.03 | < .001 | |
| rs7468 | Y177Y | C/T | 0.91/0.09‡ | 0.96/0.04 | .701 | |
| PSMB8 | rs17220206 | S70T | T/A | 0.97/0.03† | 1.00/0.00 | .701 |
| PSMB9 | rs35100697 | G9E | G/A | 0.97/0.03† | 1.00/0.00 | > .999 |
| rs241419 | V32I | G/A | 0.99/0.01 | 0.98/0.02 | .701 | |
| rs17587 | R60H | G/A | 0.70/0.30 | 0.79/0.21 | .701 | |
| rs20547 | A161A | A/G | 0.99/0.01 | 0.88/0.12 | .021 | |
| rs17213861 | R173C | C/T | 0.98/0.02† | 1.00/0.00 | > .999 | |
| PSMB10 | rs20549 | L107L | T/C | 0.83/0.17 | 0.72/0.28 | .499 |
| rs14178 | G151G | T/C | 0.95/0.05 | 0.91/0.09 | .612 | |
| Gene . | SNP ID . | Amino acids . | Alleles . | NCBI frequency . | Observed frequency . | FDR P . |
|---|---|---|---|---|---|---|
| Pretreatment samples | ||||||
| PSMB1 | rs12717 | P11A | C/G | 0.61/0.39 | 0.58/0.42 | .813 |
| PSMB5 | rs11543947 | R24C | C/T | NA* | 0.95/0.05 | NA |
| PSMB6 | rs3169950 | A21A | G/A | 0.57/0.43 | 0.67/0.33 | .386 |
| rs11552523 | T56T | T/C | 0.99/0.02† | 0.98/0.02 | > .999 | |
| rs2304974 | P107A | C/G | 0.91/0.09† | 0.94/0.06 | .746 | |
| rs2304975 | S115S | C/T | 0.64/0.36† | 0.77/0.23 | .081 | |
| rs7468 | Y177Y | C/T | 0.91/0.09‡ | 0.93/0.07 | .740 | |
| PSMB8 | rs17220206 | S70T | T/A | 0.97/0.03† | 1.00/0.00 | .573 |
| PSMB9 | rs35100697 | G9E | G/A | 0.97/0.03† | 1.00/0.00 | > .999 |
| rs241419 | V32I | G/A | 0.99/0.01 | 0.98/0.02 | .777 | |
| rs17587 | R60H | G/A | 0.70/0.30 | 0.77/0.23 | .635 | |
| rs20547 | A161A | A/G | 0.99/0.01 | 0.94/0.06 | .081 | |
| rs17213861 | R173C | C/T | 0.98/0.02† | 1.00/0.00 | .740 | |
| PSMB10 | rs20549 | L107L | T/C | 0.83/0.17 | 0.72/0.28 | .168 |
| rs14178 | G151G | T/C | 0.95/0.05 | 0.87/0.13 | .057 | |
| Posttreatment samples | ||||||
| PSMB1 | rs12717 | P11A | C/G | 0.61/0.39 | 0.63/0.38 | > .999 |
| PSMB5 | rs11543947 | R24C | C/T | NA* | 0.83/0.17 | NA |
| PSMB6 | rs3169950 | A21A | G/A | 0.57/0.43 | 0.41/0.59 | .499 |
| rs11552523 | T56T | T/C | 0.99/0.02† | 0.97/0.03 | .701 | |
| rs2304974 | P107A | C/G | 0.91/0.09† | 0.97/0.03 | .701 | |
| rs2304975 | S115S | C/T | 0.64/0.36† | 0.97/0.03 | < .001 | |
| rs7468 | Y177Y | C/T | 0.91/0.09‡ | 0.96/0.04 | .701 | |
| PSMB8 | rs17220206 | S70T | T/A | 0.97/0.03† | 1.00/0.00 | .701 |
| PSMB9 | rs35100697 | G9E | G/A | 0.97/0.03† | 1.00/0.00 | > .999 |
| rs241419 | V32I | G/A | 0.99/0.01 | 0.98/0.02 | .701 | |
| rs17587 | R60H | G/A | 0.70/0.30 | 0.79/0.21 | .701 | |
| rs20547 | A161A | A/G | 0.99/0.01 | 0.88/0.12 | .021 | |
| rs17213861 | R173C | C/T | 0.98/0.02† | 1.00/0.00 | > .999 | |
| PSMB10 | rs20549 | L107L | T/C | 0.83/0.17 | 0.72/0.28 | .499 |
| rs14178 | G151G | T/C | 0.95/0.05 | 0.91/0.09 | .612 | |
All frequencies totaled 1.00, although some appear not to due to being rounded to the nearest hundredth unit.
FDR indicates false discovery rate; and NA, not applicable.
NCBI frequency data are inconclusive. Bold font indicates statistical significance (FDR P < .05).
NCBI European frequency data unavailable (listed frequency is weighted average from available NCBI population data).
NCBI European frequency data unavailable (different major/minor allele depending on population).