Association results for the 10 selected SNPs in the discovery and replication phase and in secondary analyses
| Region, SNP . | Chr . | Closest gene . | Type . | Alleles . | MAF . | Discovery . | Replication . | Combined . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta . | P . | Beta . | P . | Beta . | P . | ||||||
| 3p25.2 | |||||||||||
| rs11128603 | 3 | PPARG | Index SNP | A → G | 0.102 | 0.086 | 2.9 × 10−8 | 0.031 | .1 | 0.066 | 9.4 × 10−8 |
| rs1801282 | 3 | PPARG | nsSNP | C → G | 0.127 | 0.069 | 1.4 × 10−7 | 0.026 | .1 | 0.052 | 3.1 × 10−7 |
| 7q22.1 | |||||||||||
| rs2227631 | 7 | SERPINE1 | Index SNP | A → G | 0.409 | 0.076 | 7.8 × 10−15 | 0.069 | 5.5 × 10−11 | 0.073 | 3.2 × 10−24 |
| 7q22.1 | |||||||||||
| rs6976053 | 7 | ACHE | Index SNP | T → C | 0.478 | 0.054 | 3.4 × 10−10 | 0.039 | 2.3 × 10−4 | 0.048 | 5.8 × 10−13 |
| rs2075756 | 7 | TRIP6 | nsSNP | A → G | 0.282 | 0.058 | 2.7 × 10−9 | 0.043 | 2.8 × 10−4 | 0.052 | 5.0 × 10−12 |
| rs314376 | 7 | SLC12A9 | Tag SNP | G → A | 0.483 | 0.052 | 2.4 × 10−9 | 0.041 | 1.4 × 10−4 | 0.048 | 2.0 × 10−12 |
| rs12672665 | 7 | SRRT | Tag SNP | G → A | 0.479 | 0.047 | 6.1 × 10−8 | 0.033 | 2.1 × 10−3 | 0.041 | 8.0 × 10−10 |
| rs3847067 | 7 | ACHE | Tag SNP | A → C | 0.289 | 0.059 | 4.1 × 10−10 | 0.038 | 1.1 × 10−3 | 0.051 | 4.6 × 10−12 |
| 11p15.2 | |||||||||||
| rs6486122 | 11 | ARNTL | index SNP | T → C | 0.311 | 0.051 | 3.0 × 10−8 | 0.038 | 9.8 × 10−4 | 0.046 | 1.7 × 10−10 |
| rs3816360 | 11 | ARNTL | Tag SNP | C → T | 0.333 | 0.048 | 9.9 × 10−8 | 0.031 | 5.1 × 10−3 | 0.041 | 3.9 × 10−9 |
| Region, SNP . | Chr . | Closest gene . | Type . | Alleles . | MAF . | Discovery . | Replication . | Combined . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta . | P . | Beta . | P . | Beta . | P . | ||||||
| 3p25.2 | |||||||||||
| rs11128603 | 3 | PPARG | Index SNP | A → G | 0.102 | 0.086 | 2.9 × 10−8 | 0.031 | .1 | 0.066 | 9.4 × 10−8 |
| rs1801282 | 3 | PPARG | nsSNP | C → G | 0.127 | 0.069 | 1.4 × 10−7 | 0.026 | .1 | 0.052 | 3.1 × 10−7 |
| 7q22.1 | |||||||||||
| rs2227631 | 7 | SERPINE1 | Index SNP | A → G | 0.409 | 0.076 | 7.8 × 10−15 | 0.069 | 5.5 × 10−11 | 0.073 | 3.2 × 10−24 |
| 7q22.1 | |||||||||||
| rs6976053 | 7 | ACHE | Index SNP | T → C | 0.478 | 0.054 | 3.4 × 10−10 | 0.039 | 2.3 × 10−4 | 0.048 | 5.8 × 10−13 |
| rs2075756 | 7 | TRIP6 | nsSNP | A → G | 0.282 | 0.058 | 2.7 × 10−9 | 0.043 | 2.8 × 10−4 | 0.052 | 5.0 × 10−12 |
| rs314376 | 7 | SLC12A9 | Tag SNP | G → A | 0.483 | 0.052 | 2.4 × 10−9 | 0.041 | 1.4 × 10−4 | 0.048 | 2.0 × 10−12 |
| rs12672665 | 7 | SRRT | Tag SNP | G → A | 0.479 | 0.047 | 6.1 × 10−8 | 0.033 | 2.1 × 10−3 | 0.041 | 8.0 × 10−10 |
| rs3847067 | 7 | ACHE | Tag SNP | A → C | 0.289 | 0.059 | 4.1 × 10−10 | 0.038 | 1.1 × 10−3 | 0.051 | 4.6 × 10−12 |
| 11p15.2 | |||||||||||
| rs6486122 | 11 | ARNTL | index SNP | T → C | 0.311 | 0.051 | 3.0 × 10−8 | 0.038 | 9.8 × 10−4 | 0.046 | 1.7 × 10−10 |
| rs3816360 | 11 | ARNTL | Tag SNP | C → T | 0.333 | 0.048 | 9.9 × 10−8 | 0.031 | 5.1 × 10−3 | 0.041 | 3.9 × 10−9 |