Transcripts selectively regulated in LCH cells
| . | LCH:LC . | LCH:mDC . | LCH:pDC . | ↑/↓ . |
|---|---|---|---|---|
| Matrix-degrading and tissue-remodeling enzymes | ||||
| MMP1 | ||||
| FC | 25 | 55 | 67 | ↑ |
| P | 6 × 10−8 | 2 × 10−9 | 1 × 10−9 | |
| MMP9 | ||||
| FC | 4 | 1541 | 2352 | ↑ |
| P | 3 × 10−5 | 6 × 10−16 | 2 × 10−16 | |
| MMP12 | ||||
| FC | 16 | 3300 | 4067 | ↑ |
| P | 5 × 10−6 | 1 × 10−12 | 9 × 10−13 | |
| ADAMDEC1 | ||||
| FC | 28 | 29 | 29 | ↑ |
| P | 4 × 10−3 | 4 × 10−3 | 4 × 10−3 | |
| Signaling molecules | ||||
| JAG2 | ||||
| FC | 33 | 28 | 50 | ↑ |
| P | 4 × 10−7 | 8 × 10−7 | 1 × 10−9 | |
| TNFSF10 | ||||
| FC | 45 | 7 | 64 | ↑ |
| P | 1 × 10−11 | 3 × 10−7 | 2 × 10−12 | |
| FGF2 | ||||
| FC | 11 | 11 | 12 | ↑ |
| P | 1 × 10−3 | 1 × 10−3 | 1 × 10−3 | |
| KITLG | ||||
| FC | 9 | 9 | 9 | ↑ |
| P | 1 × 10−3 | 1 × 10−3 | 1 × 10−3 | |
| GHRL | ||||
| FC | 12 | 5 | 8 | ↑ |
| P | 1 × 10−7 | 5 × 10−5 | 1 × 10−6 | |
| SEMA3C | ||||
| FC | −47 | −36 | −76 | ↓ |
| P | 2 × 10−9 | 7 × 10−9 | 4 × 10−10 | |
| PDGF C | ||||
| FC | −19 | −5 | −7 | ↓ |
| P | 7 × 10−8 | 8 × 10−5 | 2 × 10−5 | |
| Cytokine receptors | ||||
| IL7R | ||||
| FC | 47 | 148 | 247 | ↑ |
| P | 1 × 10−5 | 3 × 10−7 | 9 × 10−8 | |
| IL22RA2 | ||||
| FC | 10 | 293 | 295 | ↑ |
| P | 7 × 10−7 | 1 × 10−12 | 1 × 10−12 | |
| TNFRSF9 | ||||
| FC | 16 | 42 | 72 | ↑ |
| P | 1 × 10−6 | 2 × 10−8 | 3 × 10−9 | |
| TNFRSF10C | ||||
| FC | 13 | 11 | 14 | ↑ |
| P | 4 × 10−6 | 1 × 10−5 | 4 × 10−6 | |
| FLT3 | ||||
| FC | −87 | −406 | −341 | ↓ |
| P | 4 × 10−12 | 4 × 10−14 | 6 × 10−14 | |
| INSR | ||||
| FC | −5 | −134 | −93 | ↓ |
| P | 1 × 10−3 | 5 × 10−10 | 1 × 10−9 |
| . | LCH:LC . | LCH:mDC . | LCH:pDC . | ↑/↓ . |
|---|---|---|---|---|
| Matrix-degrading and tissue-remodeling enzymes | ||||
| MMP1 | ||||
| FC | 25 | 55 | 67 | ↑ |
| P | 6 × 10−8 | 2 × 10−9 | 1 × 10−9 | |
| MMP9 | ||||
| FC | 4 | 1541 | 2352 | ↑ |
| P | 3 × 10−5 | 6 × 10−16 | 2 × 10−16 | |
| MMP12 | ||||
| FC | 16 | 3300 | 4067 | ↑ |
| P | 5 × 10−6 | 1 × 10−12 | 9 × 10−13 | |
| ADAMDEC1 | ||||
| FC | 28 | 29 | 29 | ↑ |
| P | 4 × 10−3 | 4 × 10−3 | 4 × 10−3 | |
| Signaling molecules | ||||
| JAG2 | ||||
| FC | 33 | 28 | 50 | ↑ |
| P | 4 × 10−7 | 8 × 10−7 | 1 × 10−9 | |
| TNFSF10 | ||||
| FC | 45 | 7 | 64 | ↑ |
| P | 1 × 10−11 | 3 × 10−7 | 2 × 10−12 | |
| FGF2 | ||||
| FC | 11 | 11 | 12 | ↑ |
| P | 1 × 10−3 | 1 × 10−3 | 1 × 10−3 | |
| KITLG | ||||
| FC | 9 | 9 | 9 | ↑ |
| P | 1 × 10−3 | 1 × 10−3 | 1 × 10−3 | |
| GHRL | ||||
| FC | 12 | 5 | 8 | ↑ |
| P | 1 × 10−7 | 5 × 10−5 | 1 × 10−6 | |
| SEMA3C | ||||
| FC | −47 | −36 | −76 | ↓ |
| P | 2 × 10−9 | 7 × 10−9 | 4 × 10−10 | |
| PDGF C | ||||
| FC | −19 | −5 | −7 | ↓ |
| P | 7 × 10−8 | 8 × 10−5 | 2 × 10−5 | |
| Cytokine receptors | ||||
| IL7R | ||||
| FC | 47 | 148 | 247 | ↑ |
| P | 1 × 10−5 | 3 × 10−7 | 9 × 10−8 | |
| IL22RA2 | ||||
| FC | 10 | 293 | 295 | ↑ |
| P | 7 × 10−7 | 1 × 10−12 | 1 × 10−12 | |
| TNFRSF9 | ||||
| FC | 16 | 42 | 72 | ↑ |
| P | 1 × 10−6 | 2 × 10−8 | 3 × 10−9 | |
| TNFRSF10C | ||||
| FC | 13 | 11 | 14 | ↑ |
| P | 4 × 10−6 | 1 × 10−5 | 4 × 10−6 | |
| FLT3 | ||||
| FC | −87 | −406 | −341 | ↓ |
| P | 4 × 10−12 | 4 × 10−14 | 6 × 10−14 | |
| INSR | ||||
| FC | −5 | −134 | −93 | ↓ |
| P | 1 × 10−3 | 5 × 10−10 | 1 × 10−9 |
Transcripts that were up- or down-regulated (fold change [FC] > 2, adjusted P < .05) in LCH cells compared with all 3 indigenous DC lineages as delineated in the Venn diagrams in Figure 1 were clustered into functional groups related to LCH disease. Genes involved in matrix remodeling and signaling are shown. Arrows indicate whether transcripts were up-regulated (↑) or down-regulated (↓) in LCH cells compared with all other DC lineages. FC and P values (by Student t test) are also indicated.