Table 2 Clinical characteristic of 22... | American Society of Hematology

Table 2

Clinical characteristic of 22 P2RY8-CRLF2–positive relapse cases

Pt ID	Sex	Age at dx, y	MRD	Rem, mo	Rel site	Source	Clonal stability of P2RY8-CRLF2
P2RY8-CRLF2 major clone
715	M	8.90	IR	17	BM	AT	Conserved
737	M	9.50	IR	25	BM + CNS	AT	Reduced to minor subclone
1*	F	2.00	IR	33	BM	DE	Lost
4	F	1.40	IR	42	BM	DE	Lost
2*	M	8.70	IR	63	BM	DE	Conserved
3	M	4.60	LR	65	BM	DE	Lost
5*	F	4.10	IR	67	BM	DE	Conserved
6	F	2.70	LR	98	BM	DE	Conserved
P2RY8-CRLF2 minor subclone
775	M	13.20	IR	11	BM	AT	Lost
391	F	12.70	IR	12	BM	AT	Conserved
814	F	4.60	LR	18	BM	AT	Lost
721	M	2.50	IR	20	testis	AT	Conserved
778	M	4.20	IR	20	BM	AT	Lost
810	M	4.90	IR	28	BM + CNS	AT	Lost
579	M	1.30	IR	35	BM	AT	Lost
460	F	5.70	IR	36	BM	AT	Lost
571	M	9.20	IR	44	BM	AT	Lost
456	M	12.00	IR	48	BM	AT	Conserved
545	M	4.70	LR	55	BM	AT	Lost
564*	M	8.25	LR	55	BM	AT	Different minor subclone
417*	F	9.75		60	BM	AT	Conserved
243*	F	10.40	IR	71	BM	AT	Conserved

Pt ID	Sex	Age at dx, y	MRD	Rem, mo	Rel site	Source	Clonal stability of P2RY8-CRLF2
P2RY8-CRLF2 major clone
715	M	8.90	IR	17	BM	AT	Conserved
737	M	9.50	IR	25	BM + CNS	AT	Reduced to minor subclone
1*	F	2.00	IR	33	BM	DE	Lost
4	F	1.40	IR	42	BM	DE	Lost
2*	M	8.70	IR	63	BM	DE	Conserved
3	M	4.60	LR	65	BM	DE	Lost
5*	F	4.10	IR	67	BM	DE	Conserved
6	F	2.70	LR	98	BM	DE	Conserved
P2RY8-CRLF2 minor subclone
775	M	13.20	IR	11	BM	AT	Lost
391	F	12.70	IR	12	BM	AT	Conserved
814	F	4.60	LR	18	BM	AT	Lost
721	M	2.50	IR	20	testis	AT	Conserved
778	M	4.20	IR	20	BM	AT	Lost
810	M	4.90	IR	28	BM + CNS	AT	Lost
579	M	1.30	IR	35	BM	AT	Lost
460	F	5.70	IR	36	BM	AT	Lost
571	M	9.20	IR	44	BM	AT	Lost
456	M	12.00	IR	48	BM	AT	Conserved
545	M	4.70	LR	55	BM	AT	Lost
564*	M	8.25	LR	55	BM	AT	Different minor subclone
417*	F	9.75		60	BM	AT	Conserved
243*	F	10.40	IR	71	BM	AT	Conserved

Pt indicates patient; dx, initial diagnosis; MRD, minimal residual disease risk classification; Rem, remission; Rel, relapse; BM, bone marrow; and CNS, central nervous system.

Down syndrome.

View Large

This Feature Is Available To Subscribers Only