Hematologic parameters of TWAA and TWSS mice treated with 1H1 rat anti–mouse TF or control rat IgG antibodies
| Variable . | TWAA/IgG . | TWAA/1H1 . | TWSS/IgG . | TWSS/1H1 . |
|---|---|---|---|---|
| RBCs, 106/μL | 9.7 ± 0.5 | 9.7 ± 0.5 | 6.2 ± 0.9** | 6.2 ± 0.5†† |
| Hemoglobin, g/dL | 9.1 ± 0.3 | 9.3 ± 0.4 | 7.7 ± 0.7** | 7.6 ± 0.6†† |
| Hematocrit, % | 34.1 ± 1.3 | 33.9 ± 1.6 | 30.3 ± 2.5* | 30.6 ± 2.4† |
| MCV, fL | 35.2 ± 1.1 | 34.9 ± 0.9 | 48.8 ± 4.7** | 49.5 ± 4.1†† |
| MCH, pg | 9.4 ± 0.2 | 9.6 ± 0.3 | 12.2 ± 1.1** | 12.6 ± 1.0†† |
| MCHC, g/dL | 26.8 ± 0.5 | 27.6 ± 0.6 | 24.9 ± 0.4** | 25.4 ± 0.6†† |
| RDW, % | 23 ± 1.7 | 22.1 ± 1.2 | 33.4 ± 2.2** | 32.7 ± 2.4†† |
| WBCs, 103/μL | 4.3 ± 1.3 | 6.1 ± 2.0 | 45.6 ± 15.9** | 36.8 ± 8.4†† |
| Neutrophils, 103/μL | 0.8 ± 0.3 | 1.4 ± 0.5 | 8.0 ± 3.3** | 5.8 ± 2.1† |
| Lymphocytes, 103/μL | 3.2 ± 0.9 | 4.4 ± 1.5 | 34.4 ± 12.4** | 28.5 ± 5.7†† |
| Monocytes, 103/μL | 0.2 ± 0.1 | 0.2 ± 0.1 | 3.0 ± 1.2** | 2.3 ± 0.8†† |
| Platelets, 103/μL | 705 ± 54 | 746 ± 37 | 894 ± 145* | 878 ± 69 |
| Variable . | TWAA/IgG . | TWAA/1H1 . | TWSS/IgG . | TWSS/1H1 . |
|---|---|---|---|---|
| RBCs, 106/μL | 9.7 ± 0.5 | 9.7 ± 0.5 | 6.2 ± 0.9** | 6.2 ± 0.5†† |
| Hemoglobin, g/dL | 9.1 ± 0.3 | 9.3 ± 0.4 | 7.7 ± 0.7** | 7.6 ± 0.6†† |
| Hematocrit, % | 34.1 ± 1.3 | 33.9 ± 1.6 | 30.3 ± 2.5* | 30.6 ± 2.4† |
| MCV, fL | 35.2 ± 1.1 | 34.9 ± 0.9 | 48.8 ± 4.7** | 49.5 ± 4.1†† |
| MCH, pg | 9.4 ± 0.2 | 9.6 ± 0.3 | 12.2 ± 1.1** | 12.6 ± 1.0†† |
| MCHC, g/dL | 26.8 ± 0.5 | 27.6 ± 0.6 | 24.9 ± 0.4** | 25.4 ± 0.6†† |
| RDW, % | 23 ± 1.7 | 22.1 ± 1.2 | 33.4 ± 2.2** | 32.7 ± 2.4†† |
| WBCs, 103/μL | 4.3 ± 1.3 | 6.1 ± 2.0 | 45.6 ± 15.9** | 36.8 ± 8.4†† |
| Neutrophils, 103/μL | 0.8 ± 0.3 | 1.4 ± 0.5 | 8.0 ± 3.3** | 5.8 ± 2.1† |
| Lymphocytes, 103/μL | 3.2 ± 0.9 | 4.4 ± 1.5 | 34.4 ± 12.4** | 28.5 ± 5.7†† |
| Monocytes, 103/μL | 0.2 ± 0.1 | 0.2 ± 0.1 | 3.0 ± 1.2** | 2.3 ± 0.8†† |
| Platelets, 103/μL | 705 ± 54 | 746 ± 37 | 894 ± 145* | 878 ± 69 |
No statistically significant differences were observed between the following groups: TWAA/IgG vs TWAA/1H1 and TWSS/IgG vs TWSS/1H1.
RBCs indicates red blood cells; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; and WBCs, white blood cells.
Statistical difference in hematologic parameters between TWAA and TWSS mice treated with control rat IgG antibody: *P < .01; and **P < .001.
Statistical difference in hematologic parameters between TWAA and TWSS mice treated with rat anti–mouse TF antibody: †P < .01; and ††P < .001.