Table 3 Lymphoid malignancy in Lin28b... | American Society of Hematology

Table 3

Lymphoid malignancy in Lin28b mice

ID	Diagnosis	Sex	Founder	Age, mo	Gross findings	CBC WBC	NE	LY	PLT	Hb	IHC Pathology	CD3	B220	FACS CD3	B220	CD4 SP	CD8 SP	Tcrb Rgmt
C3	PTCL	M	C3	5	L, LN, S	21.40	16.38	3.97	177	14.0	LN Lung	+++ +++	+ +	38	10	45	1	+
6179	PTCL	F	C3	7	S	68.17	39.70	5.80	789	15.5	LN	ND	ND	45	3	ND	ND	+
6179	PTCL	F	C3	7	S	68.17	39.70	5.80	789	15.5	Lung	+++	+	45	3	ND	ND	+
6180	PTCL	F	C3	12	H, L, LN, S	5.52	2.36	2.68	587	13.4	LN	+++	++	47	5	81	0.06	+
6180	PTCL	F	C3	12	H, L, LN, S	5.52	2.36	2.68	587	13.4	Lung	+++	+	47	5	81	0.06	+
6222	PTCL	F	C3	14	H, Pl. ef., LN, S	6.40	4.88	0.92	605	11.7	LN	+++	++	69	4	68	1	+
6222	PTCL	F	C3	14	H, Pl. ef., LN, S	6.40	4.88	0.92	605	11.7	Lung	++	+	69	4	68	1	+
6226	PTCL	F	C3	17	H, L, LN, S	14.06	9.71	3.06	382	12.6	Thymus/LN	+++	++	61	21	78	1	+
6226	PTCL	F	C3	17	H, L, LN, S	14.06	9.71	3.06	382	12.6	Lung	++	++	61	21	78	1	+
6250	PTCL	M	C3	18	H, L, LN	12.14	6.41	5.21	982	12.5	Lung	++	+	30	15	18	14	-
6252	PTCL	M	C3	18	LN, S	ND					Lung	++	ND	51	11	14	41	+
6252	PTCL	M	C3	18	LN, S	ND					LN	+++	ND	51	11	14	41	+
6253	PTCL	M	C3	14	LN, S	4.74	3.34	0.96	742	12.8	LN	+++	+++	35	57	49	2	+
6253	PTCL	M	C3	14	LN, S	4.74	3.34	0.96	742	12.8	Lung	++	++	35	57	49	2	+
6292	PTCL	F	C3	13	LN	6.32	2.10	3.94	886	14.5	LN	+	++	23	23	30	10	-
6292	PTCL	F	C3	13	LN	6.32	2.10	3.94	886	14.5	Lung	++	++	23	23	30	10	-
6145	PTCL	M	D4	18.5	H, LN, S	2.64	2.03	0.36	429	6.1	Lung	++	++	65	6	58	2	+
6145	PTCL	M	D4	18.5	H, LN, S	2.64	2.03	0.36	429	6.1	LN	+++	+	65	6	58	2	+
6206	PTCL	M	D4	14.5	LN, S	1.56	0.85	0.46	787	8.3	LN	+++	+	72	5	73	2	+
6206	PTCL	M	D4	14.5	LN, S	1.56	0.85	0.46	787	8.3	Lung	+++	+	72	5	73	2	+
6207	PTCL	M	D4	10	H	4.36	2.89	1.19	919	8.8	Lung	++	++	27	6	28	0.25	+
6208	PTCL	M	D4	10	H, LN, S	21.72	14.24	2.42	400	7.4	LN	+++	++	86	2	91	1	+
6208	PTCL	M	D4	10	H, LN, S	21.72	14.24	2.42	400	7.4	Lung	+++	++	86	2	91	1	+
6214	PTCL	F	D4	14.5	L, LN, S	29.32	11.85	11.31	258	11.2	LN	+++	++	52	1	33	1	+
6214	PTCL	F	D4	14.5	L, LN, S	29.32	11.85	11.31	258	11.2	Lung	+++	++	52	1	33	1	+
6216	PTCL	M	D4	16	H, LN, S	10.16	6.51	2.70	270	10.2	LN	+	+	5	28	82	1	-
6216	PTCL	M	D4	16	H, LN, S	10.16	6.51	2.70	270	10.2	Lung	++	++	5	28	82	1	-
6219	PTCL	F	D4	12.5	Asc., H, LN, S	19.7	7.78	9.44	520	7.5	LN	+++	+	75	1	77	0.05	+
6219	PTCL	F	D4	12.5	Asc., H, LN, S	19.7	7.78	9.44	520	7.5	Lung	++	++	75	1	77	0.05	+
6220	PTCL	F	D4	12.5	LN, S	40.36	18.77	11.87	512	12.5	Lung	+++	++	20	24	71	1	+
6230	PTCL	F	D4	L, LN, S	8.66	6.38	1.82	88	7.9	LN	++	+	59	3	53	1	+
6230	PTCL	F	D4	L, LN, S	8.66	6.38	1.82	88	7.9	LN	Lung	++	+	3	53	1	+
6235	PTCL	M	D4	12	H, LN, S	18.18	7.10	9.33	316	11.3	Lung	+++	++	62	10	37	7	+
6239	Pre-T LBL	F	D4	18	L, LN, S, T	213.18	38.94	138.75	596	13.8	LN	+++	ND	38	1	1	93	+
6239	Pre-T LBL	F	D4	18	L, LN, S, T	213.18	38.94	138.75	596	13.8	Lung	++	ND	38	1	1	93	+
6178	Pancytopenia	F	C3	12	LN, S	1.08	0.17	0.79	162	2.4	LN	ND	ND	19	37	23	8	ND
6178	Pancytopenia	F	C3	12	LN, S	1.08	0.17	0.79	162	2.4	Liver	-	-	19	37	23	8	ND
6168*	PTCL	F	D10	10	L, LN, S	7.14	5.84	0.69	671	13.8	LN	+++	++	90	6	88	0.23	+
6168*	PTCL	F	D10	10	L, LN, S	7.14	5.84	0.69	671	13.8	Lung	++	++	90	6	88	0.23	+
6266*	PTCL	F	D10	12	L, LN, S	10.90	5.20	4.79	514	11.9	LN	+++	+	86	0.46	96	0.21	+
6266*	PTCL	F	D10	12	L, LN, S	10.90	5.20	4.79	514	11.9	Lung	+++	++	86	0.46	96	0.21	+
6275*†	PTCL	F	D4	12	Pl. ef.	1.44	0.43	0.75	573	10.6	Lung	+++	++	28	3	35	5	ND
6297*	PTCL	M	D10	13	L, LN	43.12	36.72	1.07	746	12.8	LN	+++	++	87	5	60	1	+
6297*	PTCL	M	D10	13	L, LN	43.12	36.72	1.07	746	12.8	Lung	+++	++	87	5	60	1	+
6316*	PTCL	F	C3	12	LN, S	8.20	3.69	2.92	410	12.1	LN	+++	+	56	6	35	11	+
6316*	PTCL	F	C3	12	LN, S	8.20	3.69	2.92	410	12.1	Lung	++	++	56	6	35	11	+
6358*	PTCL	M	D4	12.5	H, LN, S	13.88	4.04	8.38	669	10.1	LN	-	+++	76	9	43	1	+
6358*	PTCL	M	D4	12.5	H, LN, S	13.88	4.04	8.38	669	10.1	Lung	++	++	76	9	43	1	+
6348*	Pre-T LBL	M	C3	7	T	ND					Thymus	+++	+	41	1	42	1	+
6348*	Pre-T LBL	M	C3	7	T	ND					Spleen	++	+++	41	1	42	1	+
6412*	PTCL	M	C3	12	Asc., LN, H, S	ND					LN	+++	++	ND				+
6412*	PTCL	M	C3	12	Asc., LN, H, S	ND					Lung	++	+	ND				+
6502*	PTCL	F	D4	14	H, LN, Pl. ef., S	ND					ND			64	2	97	0.11	ND

ID	Diagnosis	Sex	Founder	Age, mo	Gross findings	CBC WBC	NE	LY	PLT	Hb	IHC Pathology	CD3	B220	FACS CD3	B220	CD4 SP	CD8 SP	Tcrb Rgmt
C3	PTCL	M	C3	5	L, LN, S	21.40	16.38	3.97	177	14.0	LN Lung	+++ +++	+ +	38	10	45	1	+
6179	PTCL	F	C3	7	S	68.17	39.70	5.80	789	15.5	LN	ND	ND	45	3	ND	ND	+
6179	PTCL	F	C3	7	S	68.17	39.70	5.80	789	15.5	Lung	+++	+	45	3	ND	ND	+
6180	PTCL	F	C3	12	H, L, LN, S	5.52	2.36	2.68	587	13.4	LN	+++	++	47	5	81	0.06	+
6180	PTCL	F	C3	12	H, L, LN, S	5.52	2.36	2.68	587	13.4	Lung	+++	+	47	5	81	0.06	+
6222	PTCL	F	C3	14	H, Pl. ef., LN, S	6.40	4.88	0.92	605	11.7	LN	+++	++	69	4	68	1	+
6222	PTCL	F	C3	14	H, Pl. ef., LN, S	6.40	4.88	0.92	605	11.7	Lung	++	+	69	4	68	1	+
6226	PTCL	F	C3	17	H, L, LN, S	14.06	9.71	3.06	382	12.6	Thymus/LN	+++	++	61	21	78	1	+
6226	PTCL	F	C3	17	H, L, LN, S	14.06	9.71	3.06	382	12.6	Lung	++	++	61	21	78	1	+
6250	PTCL	M	C3	18	H, L, LN	12.14	6.41	5.21	982	12.5	Lung	++	+	30	15	18	14	-
6252	PTCL	M	C3	18	LN, S	ND					Lung	++	ND	51	11	14	41	+
6252	PTCL	M	C3	18	LN, S	ND					LN	+++	ND	51	11	14	41	+
6253	PTCL	M	C3	14	LN, S	4.74	3.34	0.96	742	12.8	LN	+++	+++	35	57	49	2	+
6253	PTCL	M	C3	14	LN, S	4.74	3.34	0.96	742	12.8	Lung	++	++	35	57	49	2	+
6292	PTCL	F	C3	13	LN	6.32	2.10	3.94	886	14.5	LN	+	++	23	23	30	10	-
6292	PTCL	F	C3	13	LN	6.32	2.10	3.94	886	14.5	Lung	++	++	23	23	30	10	-
6145	PTCL	M	D4	18.5	H, LN, S	2.64	2.03	0.36	429	6.1	Lung	++	++	65	6	58	2	+
6145	PTCL	M	D4	18.5	H, LN, S	2.64	2.03	0.36	429	6.1	LN	+++	+	65	6	58	2	+
6206	PTCL	M	D4	14.5	LN, S	1.56	0.85	0.46	787	8.3	LN	+++	+	72	5	73	2	+
6206	PTCL	M	D4	14.5	LN, S	1.56	0.85	0.46	787	8.3	Lung	+++	+	72	5	73	2	+
6207	PTCL	M	D4	10	H	4.36	2.89	1.19	919	8.8	Lung	++	++	27	6	28	0.25	+
6208	PTCL	M	D4	10	H, LN, S	21.72	14.24	2.42	400	7.4	LN	+++	++	86	2	91	1	+
6208	PTCL	M	D4	10	H, LN, S	21.72	14.24	2.42	400	7.4	Lung	+++	++	86	2	91	1	+
6214	PTCL	F	D4	14.5	L, LN, S	29.32	11.85	11.31	258	11.2	LN	+++	++	52	1	33	1	+
6214	PTCL	F	D4	14.5	L, LN, S	29.32	11.85	11.31	258	11.2	Lung	+++	++	52	1	33	1	+
6216	PTCL	M	D4	16	H, LN, S	10.16	6.51	2.70	270	10.2	LN	+	+	5	28	82	1	-
6216	PTCL	M	D4	16	H, LN, S	10.16	6.51	2.70	270	10.2	Lung	++	++	5	28	82	1	-
6219	PTCL	F	D4	12.5	Asc., H, LN, S	19.7	7.78	9.44	520	7.5	LN	+++	+	75	1	77	0.05	+
6219	PTCL	F	D4	12.5	Asc., H, LN, S	19.7	7.78	9.44	520	7.5	Lung	++	++	75	1	77	0.05	+
6220	PTCL	F	D4	12.5	LN, S	40.36	18.77	11.87	512	12.5	Lung	+++	++	20	24	71	1	+
6230	PTCL	F	D4	L, LN, S	8.66	6.38	1.82	88	7.9	LN	++	+	59	3	53	1	+
6230	PTCL	F	D4	L, LN, S	8.66	6.38	1.82	88	7.9	LN	Lung	++	+	3	53	1	+
6235	PTCL	M	D4	12	H, LN, S	18.18	7.10	9.33	316	11.3	Lung	+++	++	62	10	37	7	+
6239	Pre-T LBL	F	D4	18	L, LN, S, T	213.18	38.94	138.75	596	13.8	LN	+++	ND	38	1	1	93	+
6239	Pre-T LBL	F	D4	18	L, LN, S, T	213.18	38.94	138.75	596	13.8	Lung	++	ND	38	1	1	93	+
6178	Pancytopenia	F	C3	12	LN, S	1.08	0.17	0.79	162	2.4	LN	ND	ND	19	37	23	8	ND
6178	Pancytopenia	F	C3	12	LN, S	1.08	0.17	0.79	162	2.4	Liver	-	-	19	37	23	8	ND
6168*	PTCL	F	D10	10	L, LN, S	7.14	5.84	0.69	671	13.8	LN	+++	++	90	6	88	0.23	+
6168*	PTCL	F	D10	10	L, LN, S	7.14	5.84	0.69	671	13.8	Lung	++	++	90	6	88	0.23	+
6266*	PTCL	F	D10	12	L, LN, S	10.90	5.20	4.79	514	11.9	LN	+++	+	86	0.46	96	0.21	+
6266*	PTCL	F	D10	12	L, LN, S	10.90	5.20	4.79	514	11.9	Lung	+++	++	86	0.46	96	0.21	+
6275*†	PTCL	F	D4	12	Pl. ef.	1.44	0.43	0.75	573	10.6	Lung	+++	++	28	3	35	5	ND
6297*	PTCL	M	D10	13	L, LN	43.12	36.72	1.07	746	12.8	LN	+++	++	87	5	60	1	+
6297*	PTCL	M	D10	13	L, LN	43.12	36.72	1.07	746	12.8	Lung	+++	++	87	5	60	1	+
6316*	PTCL	F	C3	12	LN, S	8.20	3.69	2.92	410	12.1	LN	+++	+	56	6	35	11	+
6316*	PTCL	F	C3	12	LN, S	8.20	3.69	2.92	410	12.1	Lung	++	++	56	6	35	11	+
6358*	PTCL	M	D4	12.5	H, LN, S	13.88	4.04	8.38	669	10.1	LN	-	+++	76	9	43	1	+
6358*	PTCL	M	D4	12.5	H, LN, S	13.88	4.04	8.38	669	10.1	Lung	++	++	76	9	43	1	+
6348*	Pre-T LBL	M	C3	7	T	ND					Thymus	+++	+	41	1	42	1	+
6348*	Pre-T LBL	M	C3	7	T	ND					Spleen	++	+++	41	1	42	1	+
6412*	PTCL	M	C3	12	Asc., LN, H, S	ND					LN	+++	++	ND				+
6412*	PTCL	M	C3	12	Asc., LN, H, S	ND					Lung	++	+	ND				+
6502*	PTCL	F	D4	14	H, LN, Pl. ef., S	ND					ND			64	2	97	0.11	ND

Asc indicates ascites; Pl. ef., pleural effusion; H, hepatomegaly/invaded liver; L, invaded lung; LN, lymphadenopathy/lymph node; T, thymoma; and S, splenomegaly.

These mice were not part of the initial cohort but were used for other assays. Five mice (6143, 6148, 6182, 6211, and 6215) were found dead and are not included in this table. Three mice (6238, 6261, and 6284) were hunched and lethargic with extramedullary hematopoiesis in the spleen but without evidence of lymphoma.

†

The FACS data for this mouse is from BM.

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