Studies of unrelated donor stem cell transplantation in SAA
| Study (year) . | N . | Design . | Conditioning . | Graft failure, % . | Median age, y . | aGVHD grade 2-4, % . | cGVHD, % . | Survival, % . |
|---|---|---|---|---|---|---|---|---|
| Kim (2007)117 | 40 | Prospective | Cy/TBI | 5 | 27 | 30 | 38 | 75 (3 y) |
| Maury (2007)43 | 89 | Retrospective | Various | 14 | 17 | 50 | 28 | 42 (5 y) |
| Viollier (2008)42 * | 349 | Retrospective | Various | 11 | 18 | 28 | 22 | 57 (5 y) |
| Kosaka (2008)118 | 31 | Prospective | Cy/ATG/TBI; Flu/Cy/ATG/TBI | 16 | 8 | 13 | 13 | 93 (3 y) |
| Perez-Albuerne (2008)52 | 195 | Retrospective | Various | 15 | 10 | 43 | 35 | 51 (5 y) |
| Bacigalupo (2010)44 | 100 | Retrospective | Flu/Cy/ATG; Flu/Cy/ATG-TBI | 17 | 20 | 18 | 27 (no TBI) 50 (TBI group) | 75 (5 y) |
| Kang (2010)119 | 28 | Prospective | Flu/Cy/ATG | 0 | 13 | 46 | 35 | 68 (3 y) |
| Lee (2010)120 | 50 | Prospective | Cy/TBI | 0 | 28 | 46 | 50 | 88 (5 y) |
| Yagasaki (2010)48 | 31 | Retrospective | Various | 3 | 9 | 37 | 27 | 94 (5 y) |
| Study (year) . | N . | Design . | Conditioning . | Graft failure, % . | Median age, y . | aGVHD grade 2-4, % . | cGVHD, % . | Survival, % . |
|---|---|---|---|---|---|---|---|---|
| Kim (2007)117 | 40 | Prospective | Cy/TBI | 5 | 27 | 30 | 38 | 75 (3 y) |
| Maury (2007)43 | 89 | Retrospective | Various | 14 | 17 | 50 | 28 | 42 (5 y) |
| Viollier (2008)42 * | 349 | Retrospective | Various | 11 | 18 | 28 | 22 | 57 (5 y) |
| Kosaka (2008)118 | 31 | Prospective | Cy/ATG/TBI; Flu/Cy/ATG/TBI | 16 | 8 | 13 | 13 | 93 (3 y) |
| Perez-Albuerne (2008)52 | 195 | Retrospective | Various | 15 | 10 | 43 | 35 | 51 (5 y) |
| Bacigalupo (2010)44 | 100 | Retrospective | Flu/Cy/ATG; Flu/Cy/ATG-TBI | 17 | 20 | 18 | 27 (no TBI) 50 (TBI group) | 75 (5 y) |
| Kang (2010)119 | 28 | Prospective | Flu/Cy/ATG | 0 | 13 | 46 | 35 | 68 (3 y) |
| Lee (2010)120 | 50 | Prospective | Cy/TBI | 0 | 28 | 46 | 50 | 88 (5 y) |
| Yagasaki (2010)48 | 31 | Retrospective | Various | 3 | 9 | 37 | 27 | 94 (5 y) |
Outcomes shown are for the entire cohort reported in each study. Studies that include 4 or more conditioning regimens are reported as “various.” Only publications with more than 20 patients reported in the past 5 years are shown.
Cy indicates cyclophosphamide; TBI, total body irradiation; Flu, fludarabine; aGVHD, acute GVHD; and cGVHD, chronic GVHD.
In Viollier et al, only the most recent cohort (after 1998) reported is shown.