Differential diagnosis of mature T-cell leukemias by immunophenotype
| Immunophenotype . | T-PLL . | T-LGL . | SS . | ATLL . |
|---|---|---|---|---|
| CD2 | + | + | + | + |
| CD3 | + | + | + | ± |
| CD7 | + | ± | ± | − |
| (strong) | ||||
| CD4 | + | − | + | + |
| (in 60%) | (rarely +) | (most) | (most) | |
| CD8 | + | + | Rare | Rare |
| (15%) | ||||
| CD4/CD8 coexpression | + (25%) | Rare | Rare | Rare |
| Other antigen expression | CD 57/CD16 (often) | CD25 in most cases |
| Immunophenotype . | T-PLL . | T-LGL . | SS . | ATLL . |
|---|---|---|---|---|
| CD2 | + | + | + | + |
| CD3 | + | + | + | ± |
| CD7 | + | ± | ± | − |
| (strong) | ||||
| CD4 | + | − | + | + |
| (in 60%) | (rarely +) | (most) | (most) | |
| CD8 | + | + | Rare | Rare |
| (15%) | ||||
| CD4/CD8 coexpression | + (25%) | Rare | Rare | Rare |
| Other antigen expression | CD 57/CD16 (often) | CD25 in most cases |
T-PLL indicates T-cell prolymphocytic leukemia; T-LGL, T-large granular lymphocytic leukemia; SS, Sezary syndrome; and ATLL, adult T-cell leukemia lymphoma.