DLT indicates dose-limiting toxicities; and MTD, maximum tolerated dose.

Time-to event continual reassessment method single-parameter logistic model.

Neutropenia, grade 3, asymptomatic, resolved within a few days.

One patient with grade 4 pulmonary edema; it resolved with diuresis but the patient withdrew consent and switched to alternate therapy achieving CR; the second patient with grade 3 dyspnea responded to diuresis and resumed treatment at a lower carfilzomib dose level; the patient continued on this dose without difficulty in subsequent cycles.