Univariate and multivariate analyses of prognostic factors for refractory/relapsed ML-DS patients
| Variables . | Univariate analysis . | Multivariate analyses . | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | Model 1 (baseline) . | Model 2 (relapsed phase) . | |||
| HR (95% CI) . | P . | HR (95% CI) . | P . | |||
| Sex: male vs female | 0.78 (0.33-1.83) | .56 | 0.71 (0.30-1.71) | .45 | 0.85 (0.36-2.05) | .72 |
| Age at initial diagnosis: ≤ 2 y vs > 2 y | 1.98 (0.83-4.72) | .12 | 2.73 (0.89-8.37) | .08 | * | |
| WBC at initial diagnosis: ≥ 10 000/μL vs < 10 000/μL | 0.57 (0.22-1.47) | .24 | 0.43 (0.15-1.19) | .10 | 0.60 (0.22-1.60) | .30 |
| FAB classification: M7 vs others | 1.63 (0.60-4.44) | .34 | 0.92 (0.27-3.09) | .89 | 1.88 (0.66-5.37) | .24 |
| Disease status: IF or RL ≤ 6 mo vs RL > 6 mo | 2.92 (1.24-6.88) | .01 | – | 3.14 (1.28-7.67) | .012 | |
| Response to r-induction therapy: non-CR vs CR | 16.54 (4.44-61.59) | < .0001 | – | * | ||
| Variables . | Univariate analysis . | Multivariate analyses . | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | Model 1 (baseline) . | Model 2 (relapsed phase) . | |||
| HR (95% CI) . | P . | HR (95% CI) . | P . | |||
| Sex: male vs female | 0.78 (0.33-1.83) | .56 | 0.71 (0.30-1.71) | .45 | 0.85 (0.36-2.05) | .72 |
| Age at initial diagnosis: ≤ 2 y vs > 2 y | 1.98 (0.83-4.72) | .12 | 2.73 (0.89-8.37) | .08 | * | |
| WBC at initial diagnosis: ≥ 10 000/μL vs < 10 000/μL | 0.57 (0.22-1.47) | .24 | 0.43 (0.15-1.19) | .10 | 0.60 (0.22-1.60) | .30 |
| FAB classification: M7 vs others | 1.63 (0.60-4.44) | .34 | 0.92 (0.27-3.09) | .89 | 1.88 (0.66-5.37) | .24 |
| Disease status: IF or RL ≤ 6 mo vs RL > 6 mo | 2.92 (1.24-6.88) | .01 | – | 3.14 (1.28-7.67) | .012 | |
| Response to r-induction therapy: non-CR vs CR | 16.54 (4.44-61.59) | < .0001 | – | * | ||
Reference groups: female > 2 years, < 10 000/μL, others (FAB), RL > 6 months, and CR.
CI indicates confidence interval; CR, complete response, HR, hazard ratio; IF, induction failure; mo, month(s); and RL, relapse.
A variable of “patient age at initial diagnosis” was excluded from model 2 because it was a predictive factor for the variable of “type of relapse/induction failure.” Patients who relapsed in the later phase (after 6 months) were more likely to achieve in CR, and therefore, a variable of “response to reinduction therapy” was also excluded from the model 2 in the multivariate analysis.