VWF laboratory test results and bleeding scores for type 1 VWD subjects with and without D1472H
| Type 1 VWD subjects . | D1472H (n = 36) . | No D1472H (n = 241) . | . | ||||
|---|---|---|---|---|---|---|---|
| Mean ± 1 SD . | Median . | Interquartile range . | Mean ± 1 SD . | Median . | Interquartile range . | P value . | |
| FVIII activity, IU/dL | 56 ± 20 | 56 | 48-72 | 55 ± 22 | 54 | 42-73 | NS |
| VWF:Ag, IU/dL | 32 ± 13 | 34 | 24-41 | 36 ± 15 | 39 | 26-48 | P < .036 |
| VWF:RCo, IU/dL* | 29 ± 10 | 30 | 23-37 | 37 ± 15 | 39 | 27-47 | P < .001 |
| VWF:RCo/VWF:Ag ratio* | 0.94 ± 0.24 | 0.92 | 0.79-1.07 | 1.04 ± 0.20 | 1.02 | 0.90-1.13 | P < .012 |
| VWF:CB, IU/dL | 34 ± 13 | 37 | 22-42 | 41 ± 18 | 46 | 29-55 | P < .01 |
| Bleeding score | 6.72 ± 6.5 | 4 | 2-11 | 5.44 ± 4.6 | 5 | 2-7 | NS |
| Type 1 VWD subjects . | D1472H (n = 36) . | No D1472H (n = 241) . | . | ||||
|---|---|---|---|---|---|---|---|
| Mean ± 1 SD . | Median . | Interquartile range . | Mean ± 1 SD . | Median . | Interquartile range . | P value . | |
| FVIII activity, IU/dL | 56 ± 20 | 56 | 48-72 | 55 ± 22 | 54 | 42-73 | NS |
| VWF:Ag, IU/dL | 32 ± 13 | 34 | 24-41 | 36 ± 15 | 39 | 26-48 | P < .036 |
| VWF:RCo, IU/dL* | 29 ± 10 | 30 | 23-37 | 37 ± 15 | 39 | 27-47 | P < .001 |
| VWF:RCo/VWF:Ag ratio* | 0.94 ± 0.24 | 0.92 | 0.79-1.07 | 1.04 ± 0.20 | 1.02 | 0.90-1.13 | P < .012 |
| VWF:CB, IU/dL | 34 ± 13 | 37 | 22-42 | 41 ± 18 | 46 | 29-55 | P < .01 |
| Bleeding score | 6.72 ± 6.5 | 4 | 2-11 | 5.44 ± 4.6 | 5 | 2-7 | NS |
22 type 1 subjects (2 with D1472H and 20 without D1472H) had a VWF:RCo <10 IU/dL (the lower limit of detection in our laboratory); therefore, a ratio was unable to be calculated and those subjects were excluded from analysis. Inclusion of these subjects using a VWF:RCo value of 5 IU/dL did not change the statistical significance of the results.