ET-related events after long-term observation
| . | Anagrelide group (n=122) . | Hydroxyurea group (n=131) . | P value . |
|---|---|---|---|
| A) Major events (total) | No. of events | No. of events | .86 |
| 14 | 16 | ||
| Major arterial thrombosis | 7 | 8 | .90 |
| Claudication | 1 | - | |
| Myocardial infarction | 3 | 2 | |
| Peripheral arterial disease | - | 2 | |
| Coronary arterial disease (bypass surgery) | 1 | - | |
| Obstruction of subclavian artery | - | 1 | |
| Cerebrovascular event/stroke | 2 | 2 | |
| Carotid artery stenosis | - | 1 | |
| Major venous thrombosis | 2 | 6 | .18 |
| Thrombosis of mesenteric venocaval shunt | 1 | - | |
| Thrombosis of V. ileofemoralis | 1 | 4 | |
| Pulmonary embolism | - | 1 | |
| Lower limb thrombosis | - | 1 | |
| Severe bleeding events | 5 | 2 | .21 |
| Rectal bleeding | 1 | - | |
| Bleeding into gluteal muscle | 1 | - | |
| Severe hypermenorrhea | 1 | - | |
| Bleeding of esophageal varices | - | 1 | |
| Metrorrhagia | - | 1 | |
| Severe bleeding after cyst puncture | 1 | - | |
| Other major bleeding events | 1 | - | |
| B) Minor events (total) | No. of events | No. of events | .18 |
| 45 | 38 | ||
| Minor arterial thrombosis | 24 | 20 | .36 |
| Microcirculatory disturbances (dysesthesia, tingling paresthesia) | 9 | 11 | |
| Other minor arterial events | - | - | |
| TIA, balance disorders, dizziness | 7 | 2 | |
| Scotoma | - | 2 | |
| Angina pectoris | 3 | 2 | |
| Erythromelalgia | 3 | 1 | |
| Myocardial ischemia | - | 1 | |
| Raynaud | 2 | 1 | |
| Minor venous thrombosis | 3 | 3 | .93 |
| Thrombophlebitis | 3 | 3 | |
| Minor bleeding events | 18 | 15 | .44 |
| Epistaxis | 7 | 9 | |
| Hypermenorrhea | 2 | - | |
| Hematoma | 1 | 2 | |
| Bleeding (uterine, nose, skin, anal fissures, gingiva) | 6 | 3 | |
| Other (ecchymosis, petechiae, blood-stained expectoration) | 2 | 1 |
| . | Anagrelide group (n=122) . | Hydroxyurea group (n=131) . | P value . |
|---|---|---|---|
| A) Major events (total) | No. of events | No. of events | .86 |
| 14 | 16 | ||
| Major arterial thrombosis | 7 | 8 | .90 |
| Claudication | 1 | - | |
| Myocardial infarction | 3 | 2 | |
| Peripheral arterial disease | - | 2 | |
| Coronary arterial disease (bypass surgery) | 1 | - | |
| Obstruction of subclavian artery | - | 1 | |
| Cerebrovascular event/stroke | 2 | 2 | |
| Carotid artery stenosis | - | 1 | |
| Major venous thrombosis | 2 | 6 | .18 |
| Thrombosis of mesenteric venocaval shunt | 1 | - | |
| Thrombosis of V. ileofemoralis | 1 | 4 | |
| Pulmonary embolism | - | 1 | |
| Lower limb thrombosis | - | 1 | |
| Severe bleeding events | 5 | 2 | .21 |
| Rectal bleeding | 1 | - | |
| Bleeding into gluteal muscle | 1 | - | |
| Severe hypermenorrhea | 1 | - | |
| Bleeding of esophageal varices | - | 1 | |
| Metrorrhagia | - | 1 | |
| Severe bleeding after cyst puncture | 1 | - | |
| Other major bleeding events | 1 | - | |
| B) Minor events (total) | No. of events | No. of events | .18 |
| 45 | 38 | ||
| Minor arterial thrombosis | 24 | 20 | .36 |
| Microcirculatory disturbances (dysesthesia, tingling paresthesia) | 9 | 11 | |
| Other minor arterial events | - | - | |
| TIA, balance disorders, dizziness | 7 | 2 | |
| Scotoma | - | 2 | |
| Angina pectoris | 3 | 2 | |
| Erythromelalgia | 3 | 1 | |
| Myocardial ischemia | - | 1 | |
| Raynaud | 2 | 1 | |
| Minor venous thrombosis | 3 | 3 | .93 |
| Thrombophlebitis | 3 | 3 | |
| Minor bleeding events | 18 | 15 | .44 |
| Epistaxis | 7 | 9 | |
| Hypermenorrhea | 2 | - | |
| Hematoma | 1 | 2 | |
| Bleeding (uterine, nose, skin, anal fissures, gingiva) | 6 | 3 | |
| Other (ecchymosis, petechiae, blood-stained expectoration) | 2 | 1 |
ET-related events between the groups were analyzed using the Cochran-Mantel-Haenzel procedure.