Affinities of parental mouse Fab 15c9 and humanized aDabi-Fab
| . | Format . | KD, pM . | ka, ×105 M−1s−1 . | kd, ×10−6 s−1 . |
|---|---|---|---|---|
| aDabi-Fab | Humanized | 2.1 ± 0.6 | 3.4 ± 0.4 | 0.7 ± 0.2 |
| Fab 15c9 | Mouse | 32 ± 11 | 42 ± 16 | 134 ± 69 |
| . | Format . | KD, pM . | ka, ×105 M−1s−1 . | kd, ×10−6 s−1 . |
|---|---|---|---|---|
| aDabi-Fab | Humanized | 2.1 ± 0.6 | 3.4 ± 0.4 | 0.7 ± 0.2 |
| Fab 15c9 | Mouse | 32 ± 11 | 42 ± 16 | 134 ± 69 |
ka, association rate constant; KD, binding affinity; kd, dissociation rate constant.
KD, ka, and calculated kd are shown mean ± SD of at least 3 individual measurements.