Table 1 Summary of effects of various... | American Society of Hematology

Table 1

Summary of effects of various antagonists on histamine, serotonin, or VEGF-A stimulation in different in vitro and in vivo angiogenic assays*

	Histamine receptor inhibitors		Serotonin receptor inhibitors
Assay	Inhibition	No inhibition	Inhibition	No inhibition
³H thymidine incorporation	H1; H2	H4	5-HT2; 5-HT3	5-HT1, 6,7
Transwell migration	H4	H1; H2	5-HT2; 5-HT3	5-HT1, 6,7
Wound-healing migration	H1; H4	H2	5-HT1, 6, 7; 5-HT3	5-HT2
Tube formation	H1; H2; H4	- -	5-HT2; 5-HT3	5-HT1, 6,7
Angiogenesis in vivo	H1; H2	H4	5-HT2; 5-HT3	5-HT1, 6,7

	Histamine receptor inhibitors		Serotonin receptor inhibitors
Assay	Inhibition	No inhibition	Inhibition	No inhibition
³H thymidine incorporation	H1; H2	H4	5-HT2; 5-HT3	5-HT1, 6,7
Transwell migration	H4	H1; H2	5-HT2; 5-HT3	5-HT1, 6,7
Wound-healing migration	H1; H4	H2	5-HT1, 6, 7; 5-HT3	5-HT2
Tube formation	H1; H2; H4	- -	5-HT2; 5-HT3	5-HT1, 6,7
Angiogenesis in vivo	H1; H2	H4	5-HT2; 5-HT3	5-HT1, 6,7

SU1489, an inhibitor of VEGFR-2, fully inhibited VEGF-A stimulation, but not that of histamine or serotonin, in all of the above assays.