Table 1 Summary of prognostic factors... | American Society of Hematology

Table 1

Summary of prognostic factors for relapse incidence, survival, and leukemia-free survival identified in the multivariate analysis

Variable	OS			RR			LFS
Variable	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Age*	1.771	1.287-2.436	<.001	1.147	0.779-1.69	NS	1.482	1.047-2.089	.027
WBC†	1.429	1.021-2.0	.038	1.22	0.779-1.910	NS	1.032	0.71-1.499	NS
FLT3 (ITD vs wild type)	1.854	1.315-2.614	<.001	2.395	1.569-3.654	.000051	1.76	1.169-2.59	.004
NPM1 (mut vs wild type)	0.676	0.484-0.944	.022	0.542	0.352-0.835	.0054	0.739	0.512-1.067	NS
NPM1mut/FLT3wt‡	0.601	0.422-0.858	.005	0.488	0.313-0.76	.0015	0.615	0.418-0.905	.014
FLT3-ITD ratio§	1.274	1.124-1.444	<.001	1.604	1.427-1.8	2 × 10⁻¹⁵	1.363	1.162-1.598	<.001

Variable	OS			RR			LFS
Variable	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Age*	1.771	1.287-2.436	<.001	1.147	0.779-1.69	NS	1.482	1.047-2.089	.027
WBC†	1.429	1.021-2.0	.038	1.22	0.779-1.910	NS	1.032	0.71-1.499	NS
FLT3 (ITD vs wild type)	1.854	1.315-2.614	<.001	2.395	1.569-3.654	.000051	1.76	1.169-2.59	.004
NPM1 (mut vs wild type)	0.676	0.484-0.944	.022	0.542	0.352-0.835	.0054	0.739	0.512-1.067	NS
NPM1mut/FLT3wt‡	0.601	0.422-0.858	.005	0.488	0.313-0.76	.0015	0.615	0.418-0.905	.014
FLT3-ITD ratio§	1.274	1.124-1.444	<.001	1.604	1.427-1.8	2 × 10⁻¹⁵	1.363	1.162-1.598	<.001

All variables analyzed for all reported outcomes (response to induction, OS, RR, and LFS) are described in the text. HR, hazard ratio; NS, not significant; 95% CI, 95% confidence interval.

Below and above the median value: 47 years old.

†

Below and above the median: 19.9 × 10⁹/L.

‡

NPM1mut/FLT3wt genotype vs all other possibilities.

Considered as a continuous variable.

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