Baseline characteristics
| Parameter (% with missing data) . | Baseline (n = 346) median (range)/number of patients (%) . | Deaths within 3 mo (n = 103) median (range)/number of patients (%) . | P value* . |
|---|---|---|---|
| Age in y (median) (0%) | 66 (37-88) | 68 (42-83) | .02 |
| Monoclonal light chain (0.8%) | |||
| κ | 73 (21) | 20 | .66 |
| λ | 274 (79) | 83 | .75 |
| Serum monoclonal protein (including light chain band only) | 270 (78) | 80 (77) | |
| Serum monoclonal protein >5 g/L | 36 (10) | 13 (12) | .377 |
| dFLC median (range) (mg/L) | 230 (12-8140) | 348 (10-8140) | .002† |
| Serum creatinine (mg/dL) (1%) | 1.3 (0.5-9.5) | 1.3 (0.5-8.7) | .99 |
| 24-h Proteinuria (g/24 h) (7%) | 1.7 (0-16) | 1.5 (0-16) | .74 |
| eGFR (mL/min) (1%) | 49 (ESRD-152) | 48 (ESRD-152) | |
| SBP (mm Hg) (9%) | 109 (65-210) | 103 (70-210) | .0002† |
| SBP ≤100 mm Hg | 93 (27) | 50 (48) | |
| Patients with eGFR <40 mL/min | 128 (37) | ||
| NT-proBNP (ng/L) (0%) | 9106 (379-216 187) | 18 184 (609-179 300) | .0002† |
| NT-proBNP >8500 ng/L | 182 (52) | 69 (67) | |
| Cardiac TnT (ng/mL)‡ (0%) | 0.1 (0.04-8.2) | 0.22 (0.04-1.87) | |
| Cardiac TnI (ng/mL)‡ (0%) | 0.18 (0.1-12) | 0.52 (0.1-8.2) | |
| Organ involvement* | |||
| Liver involvement (0.5%) | 77 (22) | 28 (27) | .15 |
| Renal involvement (0.5%) | 216 (62) | 64 (63) | .99 |
| Mean LV wall thickness (39%) | 15 (5-30) | 16.7 (7-30) | |
| Ejection fraction (39%) | 53 (12-81) | 55 (27-81) | |
| Soft tissue involvement (0.5%) | 66 (19) | 19 (18) | .86 |
| Peripheral neuropathy (0.5%) | 56 (16) | 11 (11) | .88 |
| Autonomic neuropathy (0.5%) | 55 (16) | 18 (17) | .77 |
| Gastrointestinal tract (0.5%) | 52 (15) | 12 (12) | .32 |
| Total number of organs* (0.5%) | |||
| 1 organ | 82 (24) | 28 (27) | .33 |
| 2 organs | 129 (37) | 34 (33) | .38 |
| 3 or more organs | 136 (39) | 40 (39) | .99 |
| ECOG performance status (2%) | |||
| ≤1 | 132 (38) | 20 (19) | .0001† |
| 2 | 114 (33) | 37 (36) | .45 |
| ≥3 | 95 (27) | 46 (45) | .0001† |
| NYHA class (9%) | |||
| NYHA class 1 | 50 (14) | 8 (9) | .02 |
| NYHA class 2 | 84 (24) | 24 (26) | .89 |
| NYHA class 3 or 4 | 182 (52) | 71 (65) | .0001† |
| Parameter (% with missing data) . | Baseline (n = 346) median (range)/number of patients (%) . | Deaths within 3 mo (n = 103) median (range)/number of patients (%) . | P value* . |
|---|---|---|---|
| Age in y (median) (0%) | 66 (37-88) | 68 (42-83) | .02 |
| Monoclonal light chain (0.8%) | |||
| κ | 73 (21) | 20 | .66 |
| λ | 274 (79) | 83 | .75 |
| Serum monoclonal protein (including light chain band only) | 270 (78) | 80 (77) | |
| Serum monoclonal protein >5 g/L | 36 (10) | 13 (12) | .377 |
| dFLC median (range) (mg/L) | 230 (12-8140) | 348 (10-8140) | .002† |
| Serum creatinine (mg/dL) (1%) | 1.3 (0.5-9.5) | 1.3 (0.5-8.7) | .99 |
| 24-h Proteinuria (g/24 h) (7%) | 1.7 (0-16) | 1.5 (0-16) | .74 |
| eGFR (mL/min) (1%) | 49 (ESRD-152) | 48 (ESRD-152) | |
| SBP (mm Hg) (9%) | 109 (65-210) | 103 (70-210) | .0002† |
| SBP ≤100 mm Hg | 93 (27) | 50 (48) | |
| Patients with eGFR <40 mL/min | 128 (37) | ||
| NT-proBNP (ng/L) (0%) | 9106 (379-216 187) | 18 184 (609-179 300) | .0002† |
| NT-proBNP >8500 ng/L | 182 (52) | 69 (67) | |
| Cardiac TnT (ng/mL)‡ (0%) | 0.1 (0.04-8.2) | 0.22 (0.04-1.87) | |
| Cardiac TnI (ng/mL)‡ (0%) | 0.18 (0.1-12) | 0.52 (0.1-8.2) | |
| Organ involvement* | |||
| Liver involvement (0.5%) | 77 (22) | 28 (27) | .15 |
| Renal involvement (0.5%) | 216 (62) | 64 (63) | .99 |
| Mean LV wall thickness (39%) | 15 (5-30) | 16.7 (7-30) | |
| Ejection fraction (39%) | 53 (12-81) | 55 (27-81) | |
| Soft tissue involvement (0.5%) | 66 (19) | 19 (18) | .86 |
| Peripheral neuropathy (0.5%) | 56 (16) | 11 (11) | .88 |
| Autonomic neuropathy (0.5%) | 55 (16) | 18 (17) | .77 |
| Gastrointestinal tract (0.5%) | 52 (15) | 12 (12) | .32 |
| Total number of organs* (0.5%) | |||
| 1 organ | 82 (24) | 28 (27) | .33 |
| 2 organs | 129 (37) | 34 (33) | .38 |
| 3 or more organs | 136 (39) | 40 (39) | .99 |
| ECOG performance status (2%) | |||
| ≤1 | 132 (38) | 20 (19) | .0001† |
| 2 | 114 (33) | 37 (36) | .45 |
| ≥3 | 95 (27) | 46 (45) | .0001† |
| NYHA class (9%) | |||
| NYHA class 1 | 50 (14) | 8 (9) | .02 |
| NYHA class 2 | 84 (24) | 24 (26) | .89 |
| NYHA class 3 or 4 | 182 (52) | 71 (65) | .0001† |