Thrombus stability following FeCl3-mediated injury of the carotid artery in mice expressing FVIII-BDD or FVIII-RH by AAV transduction
| FeCl3 concentration . | AAV . | FVIII expression (ng/mL) . | No thrombus . | Transient occlusive thrombi . | Stable occlusive thrombi . |
|---|---|---|---|---|---|
| 15% | PBS | 0 | 2 | 0 | 0 |
| FVIII-BDD | 60-130 | 0 | 3 | 4 | |
| FVIII-RH | 60-180 | 0 | 0 | 7 | |
| 7.5% | PBS | 0 | 3 | 0 | 0 |
| FVIII-BDD | 30-90 | 0 | 3 | 6 | |
| 95-200 | 0 | 0 | 5 | ||
| FVIII-RH | 30-90 | 0 | 1 | 4 | |
| 95-250 | 0 | 0 | 8 |
| FeCl3 concentration . | AAV . | FVIII expression (ng/mL) . | No thrombus . | Transient occlusive thrombi . | Stable occlusive thrombi . |
|---|---|---|---|---|---|
| 15% | PBS | 0 | 2 | 0 | 0 |
| FVIII-BDD | 60-130 | 0 | 3 | 4 | |
| FVIII-RH | 60-180 | 0 | 0 | 7 | |
| 7.5% | PBS | 0 | 3 | 0 | 0 |
| FVIII-BDD | 30-90 | 0 | 3 | 6 | |
| 95-200 | 0 | 0 | 5 | ||
| FVIII-RH | 30-90 | 0 | 1 | 4 | |
| 95-250 | 0 | 0 | 8 |