Table 1

Peripheral blood analyses of WT, TgPKR, TgDNPKR, and PKRKO mice

WBC, ×109/LNE, ×109/LLY, ×109/LHGB, g/dLPLT, ×109/L
3- to 4-mo old mice      
 WT (n = 22) 10.24 ± 0.65 2.01 ± 0.20 7.91 ± 0.50 13.33 ± 0.18 807.5 ± 29.49 
 TgPKR (n = 21) 7.83 ± 0.49 1.49 ± 0.15 5.99 ± 0.42 12.42 ± 0.31 670.6 ± 51.49 
 P .0056 .0304 .0056 .0142 .0245 
 TgDNPKR (n = 20) 13.60 ± 0.72 3.22 ± 0.21 10.05 ± 0.69 14.00 ± 0.16 877.3 ± 24.78 
 P .0012 .0003 .0154 .0080 .0809 
 PKRKO (n = 11) 10.40 ± 0.90 1.94 ± 0.30 8.03 ± 0.72 13.01 ± 0.41 840.5 ± 28.14 
 P .44 .38 .45 .13 .24 
10-mo-old mice      
 WT (n = 5) 9.83 ± 0.60 1.65 ± 0.27 7.77 ± 0.31 13.40 ± 0.18 788.6 ± 25.95 
 TgPKR (n = 5) 5.57 ± 1.19 1.16 ± 0.37 4.03 ± 0.99 11.02 ± 0.53 421.6 ± 85.09 
 P .0124 .3197 .0068 .0028 .0033 
 TgDNPKR (n = 5) 15.32 ± 0.62 3.52 ± 0.31 11.48 ± 0.55 14.50 ± 0.16 922.8 ± 47.73 
 P .0002 .0020 .0004 .0019 .0387 
 PKRKO (n=5) 16.48 ± 1.83 3.544 ± 0.77 11.86 ± 1.01 12.72 ± 0.42 907.2 ± 43.90 
 P .0086 .0492 .0048 .1719 .0485 
16- to 18-mo-old mice      
 WT (n = 5) 10.47 ± 1.40 2.09 ± 0.28 8.38 ± 1.12 11.14 ± 0.36 717 ± 43.4 
 TgPKR (n = 5) 5.18 ± 1.22 0.89 ± 0.24 4.29 ± 1.00 7.9 ± 0.91 401.2 ± 54.9 
 P .010 .005 .013 .005 .001 
 TgDNPKR (n =5) 15.42 ± 1.23 3.84 ± 0.40 11.58 ± 1.05 13.1 ± 0.34 855.8 ± 35.6 
 P 0.014 0.003 0.035 0.002 0.019 
 PKRKO (n = 5) 17.34 ± 1.86 5.11 ± 0.71 12.22 ± 1.21 14.56 ± 0.16 924 ± 39.08 
 P .009 .002 .024 <.001 .004 
WBC, ×109/LNE, ×109/LLY, ×109/LHGB, g/dLPLT, ×109/L
3- to 4-mo old mice      
 WT (n = 22) 10.24 ± 0.65 2.01 ± 0.20 7.91 ± 0.50 13.33 ± 0.18 807.5 ± 29.49 
 TgPKR (n = 21) 7.83 ± 0.49 1.49 ± 0.15 5.99 ± 0.42 12.42 ± 0.31 670.6 ± 51.49 
 P .0056 .0304 .0056 .0142 .0245 
 TgDNPKR (n = 20) 13.60 ± 0.72 3.22 ± 0.21 10.05 ± 0.69 14.00 ± 0.16 877.3 ± 24.78 
 P .0012 .0003 .0154 .0080 .0809 
 PKRKO (n = 11) 10.40 ± 0.90 1.94 ± 0.30 8.03 ± 0.72 13.01 ± 0.41 840.5 ± 28.14 
 P .44 .38 .45 .13 .24 
10-mo-old mice      
 WT (n = 5) 9.83 ± 0.60 1.65 ± 0.27 7.77 ± 0.31 13.40 ± 0.18 788.6 ± 25.95 
 TgPKR (n = 5) 5.57 ± 1.19 1.16 ± 0.37 4.03 ± 0.99 11.02 ± 0.53 421.6 ± 85.09 
 P .0124 .3197 .0068 .0028 .0033 
 TgDNPKR (n = 5) 15.32 ± 0.62 3.52 ± 0.31 11.48 ± 0.55 14.50 ± 0.16 922.8 ± 47.73 
 P .0002 .0020 .0004 .0019 .0387 
 PKRKO (n=5) 16.48 ± 1.83 3.544 ± 0.77 11.86 ± 1.01 12.72 ± 0.42 907.2 ± 43.90 
 P .0086 .0492 .0048 .1719 .0485 
16- to 18-mo-old mice      
 WT (n = 5) 10.47 ± 1.40 2.09 ± 0.28 8.38 ± 1.12 11.14 ± 0.36 717 ± 43.4 
 TgPKR (n = 5) 5.18 ± 1.22 0.89 ± 0.24 4.29 ± 1.00 7.9 ± 0.91 401.2 ± 54.9 
 P .010 .005 .013 .005 .001 
 TgDNPKR (n =5) 15.42 ± 1.23 3.84 ± 0.40 11.58 ± 1.05 13.1 ± 0.34 855.8 ± 35.6 
 P 0.014 0.003 0.035 0.002 0.019 
 PKRKO (n = 5) 17.34 ± 1.86 5.11 ± 0.71 12.22 ± 1.21 14.56 ± 0.16 924 ± 39.08 
 P .009 .002 .024 <.001 .004 

Complete blood count analyses were performed with TgPKR, TgDNPKR mice, and their WT or PKRKO mice. Statistical significance (P) compared with WT was calculated by Student t test.

HGB indicates hemoglobin; LY, lymphocyte; NE, neutrophil; PLT, platelet; WBC, white blood cells.

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