Differentially expressed genes in CD30+ DLBCL vs CD30– DLBCL
| Gene functional categories . | No. of genes . | Representative genes . |
|---|---|---|
| Genes upregulated in CD30+ DLBCL | ||
| Cytokines and cytokine pathways | 9 | IL-1R1, IL-12B, IL-13RA1, IL-21R, CCR7, IRF5, SOCS1, IER2, NFIB |
| TNFR family and pathways | 7 | CD30, FAS, TRAF1, NFKBIA, TNFAIP3, TNFAIP6, TNIP2 |
| Cell growth regulation | 15 | LMO2, SLP76/LCP2, PBX4, DUSP ID2, TUSC1, MIR21, CDK6 |
| MHC class II components | 2 | HLA-A /F/J, HLA-DQB1 |
| Extracelluar matrix, adhesion, and cytoskeletal organization | 20 | CDH11, THY1, CD58, CD99, TIAM2 |
| Others, including unknown | 46 | CHIC2, SOX4, SMARCA2, SUMO3 |
| Genes downregulated in CD30+ DLBCL | ||
| B-cell receptor signaling and proliferation | 14 | IGHM, IGL@, PKCB, NF-ATC1, BACH2, TCL1A, FOXP1, MIR17HG, SH2D3C |
| Cell growth regulation | 9 | CDCA7L, FZD5, PTCHD1, BTG2 |
| Extracellular matrix, adhesion, and cytoskeletal organization | 7 | ST14, SSX2IP, GPR110 |
| Others, including unknown | 35 | ARF5, GABRB2, XK, ARF5 |
| Gene functional categories . | No. of genes . | Representative genes . |
|---|---|---|
| Genes upregulated in CD30+ DLBCL | ||
| Cytokines and cytokine pathways | 9 | IL-1R1, IL-12B, IL-13RA1, IL-21R, CCR7, IRF5, SOCS1, IER2, NFIB |
| TNFR family and pathways | 7 | CD30, FAS, TRAF1, NFKBIA, TNFAIP3, TNFAIP6, TNIP2 |
| Cell growth regulation | 15 | LMO2, SLP76/LCP2, PBX4, DUSP ID2, TUSC1, MIR21, CDK6 |
| MHC class II components | 2 | HLA-A /F/J, HLA-DQB1 |
| Extracelluar matrix, adhesion, and cytoskeletal organization | 20 | CDH11, THY1, CD58, CD99, TIAM2 |
| Others, including unknown | 46 | CHIC2, SOX4, SMARCA2, SUMO3 |
| Genes downregulated in CD30+ DLBCL | ||
| B-cell receptor signaling and proliferation | 14 | IGHM, IGL@, PKCB, NF-ATC1, BACH2, TCL1A, FOXP1, MIR17HG, SH2D3C |
| Cell growth regulation | 9 | CDCA7L, FZD5, PTCHD1, BTG2 |
| Extracellular matrix, adhesion, and cytoskeletal organization | 7 | ST14, SSX2IP, GPR110 |
| Others, including unknown | 35 | ARF5, GABRB2, XK, ARF5 |