Causes of death reported in COMFORT-2 in both the ruxolitinib and BAT treatment arms after a median total follow-up of 61.1 weeks
| Ruxolitinib arm . | Best available therapy . | ||
|---|---|---|---|
| Cause . | Number of cases . | Cause . | Number of cases . |
| Myelofibrosis | 2 | Pneumonia, septic shock, multisystem organ failure, and acute myeloid leukemia | 1 |
| Hepatic failure, cerebral hemorrhage, and portal vein thrombosis after surgery for metastatic squamous cell carcinoma of the head and neck | 1 | Postsplenectomy Klebsiella pneumoniae sepsis | 1 |
| Pulmonary edema and cardiac arrhythmia | 1 | Splenectomy, peritoneal hemorrhage, and respiratory failure | 1 |
| Retroperitoneal hemorrhage after an orthopedic procedure | 1 | Renal failure and acute myeloid leukemia | 1 |
| Intestinal perforation associated with terminal ileitis | 1 | ||
| Respiratory infection | 1 | ||
| Cardiac arrest and myelofibrosis | 1 | ||
| Cardiac failure | 1 | ||
| Pulmonary extramedullary hematopoiesis and pulmonary failure | 1 | ||
| Posttransplantation lymphoproliferative disorder and multiorgan failure | 1 | ||
| Total | 11 | Total | 4 |
| Ruxolitinib arm . | Best available therapy . | ||
|---|---|---|---|
| Cause . | Number of cases . | Cause . | Number of cases . |
| Myelofibrosis | 2 | Pneumonia, septic shock, multisystem organ failure, and acute myeloid leukemia | 1 |
| Hepatic failure, cerebral hemorrhage, and portal vein thrombosis after surgery for metastatic squamous cell carcinoma of the head and neck | 1 | Postsplenectomy Klebsiella pneumoniae sepsis | 1 |
| Pulmonary edema and cardiac arrhythmia | 1 | Splenectomy, peritoneal hemorrhage, and respiratory failure | 1 |
| Retroperitoneal hemorrhage after an orthopedic procedure | 1 | Renal failure and acute myeloid leukemia | 1 |
| Intestinal perforation associated with terminal ileitis | 1 | ||
| Respiratory infection | 1 | ||
| Cardiac arrest and myelofibrosis | 1 | ||
| Cardiac failure | 1 | ||
| Pulmonary extramedullary hematopoiesis and pulmonary failure | 1 | ||
| Posttransplantation lymphoproliferative disorder and multiorgan failure | 1 | ||
| Total | 11 | Total | 4 |