Multivariate model of HLA mismatches scored in the GvH vector at the HEL (HLA-A, B, C, DRB1) and LEL (DRB3/4/5, DQ, DP) HLA loci
| . | Grades 3-4 aGvHD . | Relapse . | TRM . | Overall survival . | ||||
|---|---|---|---|---|---|---|---|---|
| RR (95% CI) . | P value . | RR (95% CI) . | P value . | RR (95% CI) . | P value . | RR (95% CI) . | P value . | |
| 8/8 | ||||||||
| 0 mm | 1 | .01* | 1 | .01* | 1 | .17* | 1 | .92* |
| 1 vs 0 | 1.41 (1.11-1.79) | .005 | 0.75 (0.59-0.95) | .02 | 1.19 (0.98-1.44) | .07 | 1.05 (0.90-1.23) | .52 |
| 2 vs 0 | 1.49 (1.16-1.92) | .002 | 0.64 (0.49-0.84) | .001 | 1.23 (1.01-1.50) | .04 | 1.05 (0.89-1.24) | .56 |
| >2 vs 0 | 1.58 (1.05-2.39) | .03 | 0.67 (0.41-1.11) | .12 | 1.30 (0.93-1.81) | .13 | 1.07 (0.80-1.42) | .65 |
| 2 vs 1 | 1.06 (0.87-1.29) | .57 | 0.86 (0.67-1.11) | .24 | 1.03 (0.88-1.22) | .68 | 1.00 (0.87-1.15) | .97 |
| >2 vs 1 | 1.12 (0.77-1.65) | .55 | 0.90 (0.55-1.47) | .68 | 1.09 (0.80-1.49) | .59 | 1.02 (0.77-1.33) | .91 |
| >2 vs 2 | 1.06 (0.72-1.57) | .77 | 1.05 (0.63-1.73) | .86 | 1.05 (0.76-1.45) | .75 | 1.02 (0.77-1.34) | .90 |
| 7/8 | ||||||||
| 0 mm | 1 | .22* | 1 | .47* | 1 | .01* | 1 | .03* |
| 1 vs 0 | 0.95 (0.70-1.30) | .77 | 0.80 (0.54-1.17) | .25 | 1.10 (0.84-1.42) | .49 | 1.01 (0.81-1.26) | .90 |
| 2 vs 0 | 1.17 (0.86-1.58) | .32 | 0.95 (0.65-1.39) | .79 | 1.29 (0.99-1.67) | .06 | 1.19 (0.95-1.49) | .13 |
| >2 vs 0 | 1.30 (0.87-1.96) | .20 | 0.68 (0.36-1.30) | .24 | 1.68 (1.20-2.37) | .003 | 1.45 (1.06-1.96) | .08 |
| 2 vs 1 | 1.22 (0.96-1.56) | .11 | 1.19 (0.85-1.65) | .31 | 1.17 (0.96-1.44) | .13 | 1.17 (0.98-1.40) | .08 |
| >2 vs 1 | 1.37 (0.95-1.96) | .09 | 0.85 (0.46-1.58) | .61 | 1.54 (1.14-2.07) | .005 | 1.43 (1.09-1.87) | .01 |
| >2 vs 2 | 1.12 (0.78-1.61) | .54 | 0.72 (0.39-1.33) | .29 | 1.31 (0.97-1.77) | .08 | 1.22 (0.92-1.60) | .16 |
| . | Grades 3-4 aGvHD . | Relapse . | TRM . | Overall survival . | ||||
|---|---|---|---|---|---|---|---|---|
| RR (95% CI) . | P value . | RR (95% CI) . | P value . | RR (95% CI) . | P value . | RR (95% CI) . | P value . | |
| 8/8 | ||||||||
| 0 mm | 1 | .01* | 1 | .01* | 1 | .17* | 1 | .92* |
| 1 vs 0 | 1.41 (1.11-1.79) | .005 | 0.75 (0.59-0.95) | .02 | 1.19 (0.98-1.44) | .07 | 1.05 (0.90-1.23) | .52 |
| 2 vs 0 | 1.49 (1.16-1.92) | .002 | 0.64 (0.49-0.84) | .001 | 1.23 (1.01-1.50) | .04 | 1.05 (0.89-1.24) | .56 |
| >2 vs 0 | 1.58 (1.05-2.39) | .03 | 0.67 (0.41-1.11) | .12 | 1.30 (0.93-1.81) | .13 | 1.07 (0.80-1.42) | .65 |
| 2 vs 1 | 1.06 (0.87-1.29) | .57 | 0.86 (0.67-1.11) | .24 | 1.03 (0.88-1.22) | .68 | 1.00 (0.87-1.15) | .97 |
| >2 vs 1 | 1.12 (0.77-1.65) | .55 | 0.90 (0.55-1.47) | .68 | 1.09 (0.80-1.49) | .59 | 1.02 (0.77-1.33) | .91 |
| >2 vs 2 | 1.06 (0.72-1.57) | .77 | 1.05 (0.63-1.73) | .86 | 1.05 (0.76-1.45) | .75 | 1.02 (0.77-1.34) | .90 |
| 7/8 | ||||||||
| 0 mm | 1 | .22* | 1 | .47* | 1 | .01* | 1 | .03* |
| 1 vs 0 | 0.95 (0.70-1.30) | .77 | 0.80 (0.54-1.17) | .25 | 1.10 (0.84-1.42) | .49 | 1.01 (0.81-1.26) | .90 |
| 2 vs 0 | 1.17 (0.86-1.58) | .32 | 0.95 (0.65-1.39) | .79 | 1.29 (0.99-1.67) | .06 | 1.19 (0.95-1.49) | .13 |
| >2 vs 0 | 1.30 (0.87-1.96) | .20 | 0.68 (0.36-1.30) | .24 | 1.68 (1.20-2.37) | .003 | 1.45 (1.06-1.96) | .08 |
| 2 vs 1 | 1.22 (0.96-1.56) | .11 | 1.19 (0.85-1.65) | .31 | 1.17 (0.96-1.44) | .13 | 1.17 (0.98-1.40) | .08 |
| >2 vs 1 | 1.37 (0.95-1.96) | .09 | 0.85 (0.46-1.58) | .61 | 1.54 (1.14-2.07) | .005 | 1.43 (1.09-1.87) | .01 |
| >2 vs 2 | 1.12 (0.78-1.61) | .54 | 0.72 (0.39-1.33) | .29 | 1.31 (0.97-1.77) | .08 | 1.22 (0.92-1.60) | .16 |
Note: supplemental Table 1 shows the number of transplants in each category when scored in the GvH vector. Models were adjusted or stratified for the following variables: grades 3-4 acute GvHD, adjusted for T depletion, disease, year of transplant; stratified on Karnofsky score; relapse, adjusted for disease and disease status, cytomegalovirus match, and Karnofsky score; TRM, adjusted for recipient age, disease, cytomegalovirus match, year of transplant, Karnofsky score, and radiation (yes or no); and overall survival, adjusted for recipient age, disease and disease status, cytomegalovirus match, year of transplant; stratified on Karnofsky score.
P values for the all comparisons made for the outcome in each match grade category.