Univariate analysis for outcomes of patients with BPDCN
| Variable . | NRM . | Relapse . | DFS . | OS . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | |
| Age at allo-SCT, y | ||||||||||||
| < 41 | 1 | 0.27-3.23 | .90 | 1 | 0.27-2.67 | .77 | 1 | 0.39-2.33 | .92 | 1 | 0.37-2.55 | .95 |
| ≥ 41 | 0.93 | 0.84 | 0.96 | 0.97 | ||||||||
| Status at allo-SCT | ||||||||||||
| CR1 | 1 | 0.16-2.44 | .49 | 1 | 1.02-9.99 | .05 | 1 | 0.82-4.86 | .13 | 1 | 0.94-6.75 | .06 |
| > CR1 or refractory | 0.63 | 3.19 | 2 | 2.53 | ||||||||
| Donor type | ||||||||||||
| Related | 1 | 0.33-7.72 | .55 | 1 | 0.34-4.52 | .74 | 1 | 0.56-4.25 | .40 | 1 | 0.61-5.77 | .27 |
| Unrelated | 1.61 | 1.24 | 1.53 | 1.88 | ||||||||
| Conditioning regimens | ||||||||||||
| RIC | 1 | 0.09-1.16 | .08 | 1 | 0.17-1.85 | .35 | 1 | 0.07-0.58 | .003 | 1 | 0.07-0.63 | .005 |
| MAC | 0.32 | 0.57 | 0.21 | 0.22 | ||||||||
| Stem cell source | ||||||||||||
| BM | 1 | .70 | 1 | .80 | 1 | .93 | 1 | .89 | ||||
| PBSCs | 0.77 | 0.20-2.99 | 1.24 | 0.32-4.82 | 1.09 | 0.40-2.98 | 1.26 | 0.43-3.72 | ||||
| Cord blood | 1.33 | 0.24-7.42 | 0.46 | 0.05-4.06 | 0.86 | 0.21-3.44 | 0.99 | 0.19-5.13 | ||||
| Chronic GVHD | ||||||||||||
| Absence | 1 | .59 | 1 | .54 | 1 | .46 | 1 | .83 | ||||
| Presence | 1.49 | 0.35-6.43 | 1.61 | 0.35-7.41 | 1.55 | 0.54-4.44 | 1.12 | 0.40-3.16 | ||||
| Variable . | NRM . | Relapse . | DFS . | OS . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | RR . | 95% CI . | P . | |
| Age at allo-SCT, y | ||||||||||||
| < 41 | 1 | 0.27-3.23 | .90 | 1 | 0.27-2.67 | .77 | 1 | 0.39-2.33 | .92 | 1 | 0.37-2.55 | .95 |
| ≥ 41 | 0.93 | 0.84 | 0.96 | 0.97 | ||||||||
| Status at allo-SCT | ||||||||||||
| CR1 | 1 | 0.16-2.44 | .49 | 1 | 1.02-9.99 | .05 | 1 | 0.82-4.86 | .13 | 1 | 0.94-6.75 | .06 |
| > CR1 or refractory | 0.63 | 3.19 | 2 | 2.53 | ||||||||
| Donor type | ||||||||||||
| Related | 1 | 0.33-7.72 | .55 | 1 | 0.34-4.52 | .74 | 1 | 0.56-4.25 | .40 | 1 | 0.61-5.77 | .27 |
| Unrelated | 1.61 | 1.24 | 1.53 | 1.88 | ||||||||
| Conditioning regimens | ||||||||||||
| RIC | 1 | 0.09-1.16 | .08 | 1 | 0.17-1.85 | .35 | 1 | 0.07-0.58 | .003 | 1 | 0.07-0.63 | .005 |
| MAC | 0.32 | 0.57 | 0.21 | 0.22 | ||||||||
| Stem cell source | ||||||||||||
| BM | 1 | .70 | 1 | .80 | 1 | .93 | 1 | .89 | ||||
| PBSCs | 0.77 | 0.20-2.99 | 1.24 | 0.32-4.82 | 1.09 | 0.40-2.98 | 1.26 | 0.43-3.72 | ||||
| Cord blood | 1.33 | 0.24-7.42 | 0.46 | 0.05-4.06 | 0.86 | 0.21-3.44 | 0.99 | 0.19-5.13 | ||||
| Chronic GVHD | ||||||||||||
| Absence | 1 | .59 | 1 | .54 | 1 | .46 | 1 | .83 | ||||
| Presence | 1.49 | 0.35-6.43 | 1.61 | 0.35-7.41 | 1.55 | 0.54-4.44 | 1.12 | 0.40-3.16 | ||||
PBSCs indicates peripheral blood stem cells; and RR, relative risk.