Coexistence of BCR-ABL1 mutations as compound and polyclonal mutations in separate clones originating from the same patient sample
| Patient ID no. . | Clones with compound mutation . | Clones with first component mutation . | Clones with second component mutation . |
|---|---|---|---|
| CML#10 | M244V/T315I/I347T/T406I (1/10) | M244V (4/10) | T315I (2/10) |
| CML#11 | G250E/M351T/L429P (1/10) | G250E/H396R (1/10) | M351T (4/10) |
| G250E/M351T (1/10) | G250E (1/10) | M351T/L341P (1/10) | |
| CML#13 | E255K/F317L (1/10) | E255K (2/10) | F317L (2/10) |
| F317L/D391G/E334K (1/10) | |||
| F317L/T389A (1/10) | |||
| CML#23 | G250E/T315I (1/10) | G250E (8/10) | T315I (1/10) |
| CML#30 | Y253H/F317L (1/10) | Y253H (2/10) | F317L (4/10) |
| CML#31 | M244V/F317L (1/8) | M244V (3/8) | F317L (2/8) |
| M244V/D391G (1/8) | |||
| CML#35 | Y253H/F359V/A366V (1/10) | Y253H (3/10) | F359V (3/10) |
| Y253H/F359V (2/10) | |||
| CML#37 | V299L/F359V (2/10) | V299L (2/10) | F359V (3/10) |
| A288T/ V299L/F359V/W423Stop (1/10) | V299L/V377A (1/10) | M244T/F359V/ T389A (1/10) | |
| CML#40 | M244V/E459K (1/10) | M244V (1/10) | E459K (2/10) |
| W423R/E459K (1/10) | |||
| K247R/E459K (1/10) | |||
| E238G/L273S/E459K (1/10) | |||
| CML#41 | E255K/T315I (8/10) | E255K (1/10) | T315I (1/10) |
| CML#44 | L387M/T315I (6/10) | L387M (2/10) | T315I (2/10) |
| CML#50 | G250E/E459K (1/9) | G250E (1/9) | E459K (3/9) |
| G250E/F317L (1/9) | L266P/E459K (1/9) | ||
| CML#51 | F311L/L341P/H396R (1/10) | E279G/F311L/E355G/W405R (1/10) | H396R (1/10) |
| L266P/K356R/H396R (1/10) | |||
| H396R/N414S (1/10) |
| Patient ID no. . | Clones with compound mutation . | Clones with first component mutation . | Clones with second component mutation . |
|---|---|---|---|
| CML#10 | M244V/T315I/I347T/T406I (1/10) | M244V (4/10) | T315I (2/10) |
| CML#11 | G250E/M351T/L429P (1/10) | G250E/H396R (1/10) | M351T (4/10) |
| G250E/M351T (1/10) | G250E (1/10) | M351T/L341P (1/10) | |
| CML#13 | E255K/F317L (1/10) | E255K (2/10) | F317L (2/10) |
| F317L/D391G/E334K (1/10) | |||
| F317L/T389A (1/10) | |||
| CML#23 | G250E/T315I (1/10) | G250E (8/10) | T315I (1/10) |
| CML#30 | Y253H/F317L (1/10) | Y253H (2/10) | F317L (4/10) |
| CML#31 | M244V/F317L (1/8) | M244V (3/8) | F317L (2/8) |
| M244V/D391G (1/8) | |||
| CML#35 | Y253H/F359V/A366V (1/10) | Y253H (3/10) | F359V (3/10) |
| Y253H/F359V (2/10) | |||
| CML#37 | V299L/F359V (2/10) | V299L (2/10) | F359V (3/10) |
| A288T/ V299L/F359V/W423Stop (1/10) | V299L/V377A (1/10) | M244T/F359V/ T389A (1/10) | |
| CML#40 | M244V/E459K (1/10) | M244V (1/10) | E459K (2/10) |
| W423R/E459K (1/10) | |||
| K247R/E459K (1/10) | |||
| E238G/L273S/E459K (1/10) | |||
| CML#41 | E255K/T315I (8/10) | E255K (1/10) | T315I (1/10) |
| CML#44 | L387M/T315I (6/10) | L387M (2/10) | T315I (2/10) |
| CML#50 | G250E/E459K (1/9) | G250E (1/9) | E459K (3/9) |
| G250E/F317L (1/9) | L266P/E459K (1/9) | ||
| CML#51 | F311L/L341P/H396R (1/10) | E279G/F311L/E355G/W405R (1/10) | H396R (1/10) |
| L266P/K356R/H396R (1/10) | |||
| H396R/N414S (1/10) |
The predominant compound mutations and their components are shown in bold. Silent mutation components are not shown in this table. The frequency of each clone is shown in proportion to the number of sequenced clones per sample.