Pharmacokinetic properties of Hu-Mikβ1 in T-LGL
| . | 0.5 mg/kg . | 1.0 mg/kg . | 1.5 mg/kg . | |||
|---|---|---|---|---|---|---|
| Geometric mean (n = 3) . | 95% CI . | Geometric mean (n = 3) . | 95% CI . | Geometric mean (n = 3) . | 95% CI . | |
| Biologic t1/2, h | 16.9 | 8.5-33.5 | 32.0 | 11.5-89.0 | 91.0 | 31.4-264 |
| Cmax, μg/mL | 5.4 | 3.9-7.3 | 10.6 | 6.3-17.9 | 23.4 | 10.6-51.4 |
| Cmax/D, /mL | 10.7 | 7.8-14.7 | 10.6 | 6.3-17.9 | 15.6 | 7.1-34.2 |
| AUCinf, mg Hg/L | 206.6 | 106.0-402.9 | 692.2 | 166.01-2885.9 | 3358.7 | 1683.0-6702.9 |
| AUCinf/D, h/L | 413.3 | 213.0-805.9 | 692.1 | 166.0-2885.9 | 2239.1 | 1122.0-4468.6 |
| Volume of distribution, L/kg | 0.059 | 0.029-0.120 | 0.066 | 0.036-0.124 | 0.0596 | 0.029-0.12 |
| Clearance, L/h/kg × 10−3 | 2.44 | 1.26-4.72 | 1.47 | 0.39-5.56 | 0.448 | 0.19-1.09 |
| . | 0.5 mg/kg . | 1.0 mg/kg . | 1.5 mg/kg . | |||
|---|---|---|---|---|---|---|
| Geometric mean (n = 3) . | 95% CI . | Geometric mean (n = 3) . | 95% CI . | Geometric mean (n = 3) . | 95% CI . | |
| Biologic t1/2, h | 16.9 | 8.5-33.5 | 32.0 | 11.5-89.0 | 91.0 | 31.4-264 |
| Cmax, μg/mL | 5.4 | 3.9-7.3 | 10.6 | 6.3-17.9 | 23.4 | 10.6-51.4 |
| Cmax/D, /mL | 10.7 | 7.8-14.7 | 10.6 | 6.3-17.9 | 15.6 | 7.1-34.2 |
| AUCinf, mg Hg/L | 206.6 | 106.0-402.9 | 692.2 | 166.01-2885.9 | 3358.7 | 1683.0-6702.9 |
| AUCinf/D, h/L | 413.3 | 213.0-805.9 | 692.1 | 166.0-2885.9 | 2239.1 | 1122.0-4468.6 |
| Volume of distribution, L/kg | 0.059 | 0.029-0.120 | 0.066 | 0.036-0.124 | 0.0596 | 0.029-0.12 |
| Clearance, L/h/kg × 10−3 | 2.44 | 1.26-4.72 | 1.47 | 0.39-5.56 | 0.448 | 0.19-1.09 |