Novel chemotherapeutic regimens for NK/T-cell lymphomas
| Regimen . | Protocol . | Reference . |
|---|---|---|
| AspaMetDex | Escherichia colil-asparaginase: 6000 U/m2 IM, days 2, 4, 6, and 8 | 16 |
| Methotrexate: 3000 mg/m2 IV, day 1 | ||
| Dexamethasone: 40 mg orally, days 1-4 | ||
| 2/3DeVIC | Dexamethasone: 40 mg IV, days 1-3 | 56 |
| Etoposide: 67 mg/m2 IV, days 1-3 | ||
| Ifosfamide: 1000 mg/m2 IV, days 1-3 | ||
| Carboplatin: 200 mg/m2 IV, day 1 | ||
| VIPD | Etoposide: 100 mg/m2 IV, days 1-3 | 57 |
| Ifosfamide: 1200 mg/m2 IV, days 1-3 | ||
| Cisplatin: 33 mg/m2 IV, days 1-3 | ||
| Dexamethasone: 40 mg IV or orally, days 1-4 | ||
| LVP | l-asparaginase: 6000 IU/m2 IV, days 1-5 | 59 |
| Vincristine: 1.4/m2 IV, day 1 | ||
| Prednisolone: 100 mg orally, days 1-5 | ||
| GELOX | Gemcitabine: 1000 mg/m2 IV, days 1 and 8 | 60 |
| E. colil-asparaginase: 6000 units/m2 IM, days 1-7 | ||
| Oxaliplatin: 130 mg/m2 IV, day 1 | ||
| SMILE | Dexamethasone: 40 mg IV or orally, days 2-4 | 62 |
| Methotrexate: 2000 mg/m2 IV, day 1 | ||
| Ifosfamide: 1500 mg/m2 IV, days 2-4 | ||
| E. colil-asparaginase: 6000 U/m2 IV, days 8, 10, 12, 14, 16, 18, and 20 | ||
| Etoposide: 100 mg/m2 IV, days 2-4 |
| Regimen . | Protocol . | Reference . |
|---|---|---|
| AspaMetDex | Escherichia colil-asparaginase: 6000 U/m2 IM, days 2, 4, 6, and 8 | 16 |
| Methotrexate: 3000 mg/m2 IV, day 1 | ||
| Dexamethasone: 40 mg orally, days 1-4 | ||
| 2/3DeVIC | Dexamethasone: 40 mg IV, days 1-3 | 56 |
| Etoposide: 67 mg/m2 IV, days 1-3 | ||
| Ifosfamide: 1000 mg/m2 IV, days 1-3 | ||
| Carboplatin: 200 mg/m2 IV, day 1 | ||
| VIPD | Etoposide: 100 mg/m2 IV, days 1-3 | 57 |
| Ifosfamide: 1200 mg/m2 IV, days 1-3 | ||
| Cisplatin: 33 mg/m2 IV, days 1-3 | ||
| Dexamethasone: 40 mg IV or orally, days 1-4 | ||
| LVP | l-asparaginase: 6000 IU/m2 IV, days 1-5 | 59 |
| Vincristine: 1.4/m2 IV, day 1 | ||
| Prednisolone: 100 mg orally, days 1-5 | ||
| GELOX | Gemcitabine: 1000 mg/m2 IV, days 1 and 8 | 60 |
| E. colil-asparaginase: 6000 units/m2 IM, days 1-7 | ||
| Oxaliplatin: 130 mg/m2 IV, day 1 | ||
| SMILE | Dexamethasone: 40 mg IV or orally, days 2-4 | 62 |
| Methotrexate: 2000 mg/m2 IV, day 1 | ||
| Ifosfamide: 1500 mg/m2 IV, days 2-4 | ||
| E. colil-asparaginase: 6000 U/m2 IV, days 8, 10, 12, 14, 16, 18, and 20 | ||
| Etoposide: 100 mg/m2 IV, days 2-4 |
IM, intramuscularly.