Table 2 Viral responses to CMV-specific... | American Society of Hematology

Table 2

Viral responses to CMV-specific T cells

Pt. no.	Viral disease	Duration of previous standard therapy (defined as ganciclovir, foscarnet, or cidofovir)	Tissue disease	Line infused	HLA match (low-resolution) with recipient	No. of infusions	Best response by 6 wk	Viral outcome
20	CMV	16 d	Yes	C2274	2/6	1	CR	Resolution of pneumonia and CMV antigenemia
22	CMV/AdV	14 d	No	C2420	2/6	1	PR	CR/CMV after 42 d, also CR/AdV
23	CMV	4 mo	Yes	C2420	2/6	1	N/E	Died day 3 post-VST infusion of HHV-7 pneumonia
27	CMV	22 d	No	C3366	3/6	1	PR	CR after day 42
30	CMV	2 mo	Yes	C3365	3/6	1	PR	PR by viral load but response not sustained.
41	CMV	32 d	No	C2353	3/6	2	PR	CR after day 42
49	CMV	4 mo	Yes	C3366	3/6	1	PR	Retinitis PR at day 42, CR later
50	CMV	9 mo	No	C3889	2/6	1	CR	Sustained CR
56	CMV	18 d	Yes	C3629	2/6	2	CR	Sustained CR
57	CMV	4 mo	Yes	C3528	2/6	3	CR	CR on viral load, also retinitis
58	CMV	4 mo	Yes	C2339	2/6	2	CR	CR after day 42
61	CMV	25 d	No	C2420	3/6	1	CR	Sustained CR
62	CMV	5 mo	Yes	C3365	2/6	1	PR	CR after day 42
67	CMV	36 d	Yes	C3466	2/6	1	N/E	No follow-up data; withdrew from study at 3 d
71	CMV	37 d	No	C3889	1/6	3	NR	Transient responses
73	CMV	3 mo	No	C3874	3/6	2	CR	Sustained CR
77	CMV	17 d	Yes	C3921	1/6	1	N/E	Died day 5 post-VST infusion of persistent CMV pneumonia
83	CMV	14 d	No	C3889	1/6	1	CR	Sustained CR
84	CMV	3 mo	No	C3889	1/6	1	NR	No response
85	CMV	34 d	Yes	C3629	2/6	1	N/E	Died day 1 post-VST infusion of CMV pneumonia
87	CMV	14 d	Yes	C3921	2/6	1	PR	PR of CMV, then died of relapsed ALL
91	CMV	2 mo	Yes	C3921	4/6	1	PR	CR after day 42
93	CMV	21 d	No	C2353	2/6	1	CR	Sustained CR

Pt. no.	Viral disease	Duration of previous standard therapy (defined as ganciclovir, foscarnet, or cidofovir)	Tissue disease	Line infused	HLA match (low-resolution) with recipient	No. of infusions	Best response by 6 wk	Viral outcome
20	CMV	16 d	Yes	C2274	2/6	1	CR	Resolution of pneumonia and CMV antigenemia
22	CMV/AdV	14 d	No	C2420	2/6	1	PR	CR/CMV after 42 d, also CR/AdV
23	CMV	4 mo	Yes	C2420	2/6	1	N/E	Died day 3 post-VST infusion of HHV-7 pneumonia
27	CMV	22 d	No	C3366	3/6	1	PR	CR after day 42
30	CMV	2 mo	Yes	C3365	3/6	1	PR	PR by viral load but response not sustained.
41	CMV	32 d	No	C2353	3/6	2	PR	CR after day 42
49	CMV	4 mo	Yes	C3366	3/6	1	PR	Retinitis PR at day 42, CR later
50	CMV	9 mo	No	C3889	2/6	1	CR	Sustained CR
56	CMV	18 d	Yes	C3629	2/6	2	CR	Sustained CR
57	CMV	4 mo	Yes	C3528	2/6	3	CR	CR on viral load, also retinitis
58	CMV	4 mo	Yes	C2339	2/6	2	CR	CR after day 42
61	CMV	25 d	No	C2420	3/6	1	CR	Sustained CR
62	CMV	5 mo	Yes	C3365	2/6	1	PR	CR after day 42
67	CMV	36 d	Yes	C3466	2/6	1	N/E	No follow-up data; withdrew from study at 3 d
71	CMV	37 d	No	C3889	1/6	3	NR	Transient responses
73	CMV	3 mo	No	C3874	3/6	2	CR	Sustained CR
77	CMV	17 d	Yes	C3921	1/6	1	N/E	Died day 5 post-VST infusion of persistent CMV pneumonia
83	CMV	14 d	No	C3889	1/6	1	CR	Sustained CR
84	CMV	3 mo	No	C3889	1/6	1	NR	No response
85	CMV	34 d	Yes	C3629	2/6	1	N/E	Died day 1 post-VST infusion of CMV pneumonia
87	CMV	14 d	Yes	C3921	2/6	1	PR	PR of CMV, then died of relapsed ALL
91	CMV	2 mo	Yes	C3921	4/6	1	PR	CR after day 42
93	CMV	21 d	No	C2353	2/6	1	CR	Sustained CR

HHV-7, human herpesvirus-7; N/E, not evaluable; NR, no response; SD, stable disease.