Viral responses to AdV-specific T cells
| Pt. no. . | Viral disease . | Duration of previous standard therapy . | Line infused . | HLA match (low-resolution) to recipient . | No. of infusions . | Best response by 6 wk . | Comments . |
|---|---|---|---|---|---|---|---|
| 18 | AdV | Cidofovir 33 d | C2582 | 1/6 | 1 | PR | PR based on AdV in stool Resolution of elevated liver enzymes |
| 21 | AdV | Cidofovir 40 d | C2339 | 2/6 | 1 | CR | Sustained CR |
| 25 | AdV | Cidofovir 38 d | C3466 | 2/6 | 1 | PR | CR after day 42 |
| 26 | AdV | Renal function precluded use of cidofovir | C3528 | 1/6 | 1 | NR | Died at 14 d postinfusion of progressive AdV infection |
| 38 | AdV | Cidofovir 36 d | C3005 | 2/6 | 2 | PR | CR after day 42 |
| 40 | AdV | Renal function precluded use of cidofovir | C2339 | 2/6 | 1 | NR | Died day 9 post-VST infusion of progressive AdV infection |
| 52 | AdV | Renal function precluded use of cidofovir | C3889 | 1/6 | 1 | PR | CR after day 42 |
| 59 | AdV | Cidofovir 29 d | C2457 | 1/6 | 1 | CR | Sustained CR |
| 68 | AdV | Cidofovir 20 d | C3889 | 1/6 | 3 | PR | PRs but recurrences |
| 69 | AdV/CMV | Cidofovir 5 d - unable to tolerate because of renal function | C3629 | 4/6 | 1 | CR | Sustained CR/AdV; also CR/CMV and resolution CMV colitis |
| 70 | AdV | Cidofovir 3 mo | C2270 | 2/6 | 1 | N/E | Died at 6 d postinfusion of progressive AdV infection |
| 76 | AdV | Cidofovir 9 d | C2457 | 3/6 | 1 | CR | Sustained CR |
| 81 | AdV | Cidofovir 3 wk | C3005 | 3/6 | 1 | NR | Died day 19 post-VST infusion of persistent AdV infection |
| 86 | AdV | Cidofovir 20 d | C2339 | 3/6 | 2 | PR | PR but recurrence, died day 18 post-VST of AdV and paraflu |
| 88 | AdV | Cidofovir 7 d | C4378 | 2/6 | 1 | PR | Sustained CR |
| 94 | AdV | Cidofovir 8 d | C3617 | 2/6 | 1 | CR | Sustained CR |
| 96 | AdV | Cidofovir 14 d | C2353 | 2/6 | 1 | CR | Sustained CR |
| 97 | AdV/CMV | Cidofovir 31 d | C3629 | 2/6 | 1 | CR | Sustained CR; Also CR of CMV |
| Pt. no. . | Viral disease . | Duration of previous standard therapy . | Line infused . | HLA match (low-resolution) to recipient . | No. of infusions . | Best response by 6 wk . | Comments . |
|---|---|---|---|---|---|---|---|
| 18 | AdV | Cidofovir 33 d | C2582 | 1/6 | 1 | PR | PR based on AdV in stool Resolution of elevated liver enzymes |
| 21 | AdV | Cidofovir 40 d | C2339 | 2/6 | 1 | CR | Sustained CR |
| 25 | AdV | Cidofovir 38 d | C3466 | 2/6 | 1 | PR | CR after day 42 |
| 26 | AdV | Renal function precluded use of cidofovir | C3528 | 1/6 | 1 | NR | Died at 14 d postinfusion of progressive AdV infection |
| 38 | AdV | Cidofovir 36 d | C3005 | 2/6 | 2 | PR | CR after day 42 |
| 40 | AdV | Renal function precluded use of cidofovir | C2339 | 2/6 | 1 | NR | Died day 9 post-VST infusion of progressive AdV infection |
| 52 | AdV | Renal function precluded use of cidofovir | C3889 | 1/6 | 1 | PR | CR after day 42 |
| 59 | AdV | Cidofovir 29 d | C2457 | 1/6 | 1 | CR | Sustained CR |
| 68 | AdV | Cidofovir 20 d | C3889 | 1/6 | 3 | PR | PRs but recurrences |
| 69 | AdV/CMV | Cidofovir 5 d - unable to tolerate because of renal function | C3629 | 4/6 | 1 | CR | Sustained CR/AdV; also CR/CMV and resolution CMV colitis |
| 70 | AdV | Cidofovir 3 mo | C2270 | 2/6 | 1 | N/E | Died at 6 d postinfusion of progressive AdV infection |
| 76 | AdV | Cidofovir 9 d | C2457 | 3/6 | 1 | CR | Sustained CR |
| 81 | AdV | Cidofovir 3 wk | C3005 | 3/6 | 1 | NR | Died day 19 post-VST infusion of persistent AdV infection |
| 86 | AdV | Cidofovir 20 d | C2339 | 3/6 | 2 | PR | PR but recurrence, died day 18 post-VST of AdV and paraflu |
| 88 | AdV | Cidofovir 7 d | C4378 | 2/6 | 1 | PR | Sustained CR |
| 94 | AdV | Cidofovir 8 d | C3617 | 2/6 | 1 | CR | Sustained CR |
| 96 | AdV | Cidofovir 14 d | C2353 | 2/6 | 1 | CR | Sustained CR |
| 97 | AdV/CMV | Cidofovir 31 d | C3629 | 2/6 | 1 | CR | Sustained CR; Also CR of CMV |
Abbreviations are explained in Table 2.