Table 1

Causes of activated platelets in PNH

1. Complement-mediated through loss of CD59 and assembly of C5b-9 on the surface 
2. NO depletion 
3. Direct effects of free hemoglobin 
4. Increased levels of reactive oxygen species 
5. Endothelial dysfunction 
6. Thrombin activation 
1. Complement-mediated through loss of CD59 and assembly of C5b-9 on the surface 
2. NO depletion 
3. Direct effects of free hemoglobin 
4. Increased levels of reactive oxygen species 
5. Endothelial dysfunction 
6. Thrombin activation 
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