Candidate SOX17 target genes according to ChIP-chip scores
| Rank . | Symbol . | Gene name . | Fold enrichment . | GO term . | Fold difference . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Vasculogenesis . | Positive regulation of erythrocyte differentiation . | Hemopoiesis . | Sox17 ECs d6/ECs d6 . | Sox17 pre-HPCs d8/pre-HPCs d8 . | Sox17 HPCs d8/HPCs d8 . | ||||
| 1 | GPSM3 | G-protein signaling modulator 3 | 48.50 | No | No | No | 1.38 | 2.42 | 2.56 |
| 2 | MAST4 | Microtubule associated serine/threonine kinase family member 4 | 41.62 | No | No | No | 1.02 | 3.22 | 4.75 |
| 3 | TXLNB | Taxilin beta, muscle-derived protein 77 | 38.05 | No | No | No | 1.18 | 2.89 | 4.29 |
| 4 | EGOT | Eosinophil granule ontogeny transcript | 37.53 | No | No | No | ND | ND | ND |
| 5 | PPBPL1 | Pro-platelet basic protein-like 1 | 35.26 | No | No | No | ND | ND | ND |
| 6 | MFSD6 | Major facilitator superfamily domain containing 6 | 30.27 | No | No | No | 19.79 | 14.24 | 19.26 |
| 7 | CDH5 | Cadherin 5, type 2 | 29.86 | No | No | No | 0.70 | 9.07 | 10.81 |
| 8 | BCL6B | B-cell CLL/lymphoma 6, member B | 28.05 | No | No | No | 1.11 | 5.73 | 8.50 |
| 9 | C1orf55 | Chromosome 1 open reading frame 55 | 25.81 | No | No | No | 2.23 | 1.77 | 1.44 |
| 10 | PTTG1IP | Pituitary tumor-transforming 1 interacting protein | 25.28 | No | No | No | 0.93 | 1.49 | 1.67 |
| 11 | TRIM67 | Tripartite motif containing 67 | 24.08 | No | No | No | 4.16 | 4.29 | 5.03 |
| 12 | MYCT1 | myc target 1myc target 1 | 21.26 | No | No | No | 0.74 | 2.90 | 7.66 |
| 13 | CD40LG | CD40 ligand | 14.12 | No | No | No | 6.65 | 11.57 | 16.69 |
| 14 | SCOC | Short coiled-coil protein | 13.45 | No | No | No | 0.97 | 0.79 | 1.04 |
| 15 | PPP1R16B | Protein phosphatase 1, regulatory subunit 16B | 13.18 | No | No | No | 0.70 | 1.83 | 1.15 |
| 19 | ACVR2A | Activin A receptor, type IIA | 9.45 | No | Yes | No | 0.15 | 0.42 | 0.67 |
| 26 | HHEX | Hematopoietically expressed homeobox | 6.87 | Yes | No | Yes | 0.66 | 1.44 | 0.89 |
| 37 | RUNX1 | runt-related transcription factor 1 | 5.46 | No | No | Yes | 5.02 | 1.25 | 1.12 |
| 41 | TAL1/SCL | T-cell acute lymphocytic leukemia 1 | 5.28 | No | Yes | Yes | 1.82 | 1.76 | 1.92 |
| 50 | EGFL7 | EGF-like-domain, multiple 7 | 4.69 | Yes | No | No | 0.67 | 2.11 | 1.92 |
| 69 | JUNB | jun B protooncogene | 3.78 | Yes | No | No | 3.50 | 3.87 | 3.24 |
| Rank . | Symbol . | Gene name . | Fold enrichment . | GO term . | Fold difference . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Vasculogenesis . | Positive regulation of erythrocyte differentiation . | Hemopoiesis . | Sox17 ECs d6/ECs d6 . | Sox17 pre-HPCs d8/pre-HPCs d8 . | Sox17 HPCs d8/HPCs d8 . | ||||
| 1 | GPSM3 | G-protein signaling modulator 3 | 48.50 | No | No | No | 1.38 | 2.42 | 2.56 |
| 2 | MAST4 | Microtubule associated serine/threonine kinase family member 4 | 41.62 | No | No | No | 1.02 | 3.22 | 4.75 |
| 3 | TXLNB | Taxilin beta, muscle-derived protein 77 | 38.05 | No | No | No | 1.18 | 2.89 | 4.29 |
| 4 | EGOT | Eosinophil granule ontogeny transcript | 37.53 | No | No | No | ND | ND | ND |
| 5 | PPBPL1 | Pro-platelet basic protein-like 1 | 35.26 | No | No | No | ND | ND | ND |
| 6 | MFSD6 | Major facilitator superfamily domain containing 6 | 30.27 | No | No | No | 19.79 | 14.24 | 19.26 |
| 7 | CDH5 | Cadherin 5, type 2 | 29.86 | No | No | No | 0.70 | 9.07 | 10.81 |
| 8 | BCL6B | B-cell CLL/lymphoma 6, member B | 28.05 | No | No | No | 1.11 | 5.73 | 8.50 |
| 9 | C1orf55 | Chromosome 1 open reading frame 55 | 25.81 | No | No | No | 2.23 | 1.77 | 1.44 |
| 10 | PTTG1IP | Pituitary tumor-transforming 1 interacting protein | 25.28 | No | No | No | 0.93 | 1.49 | 1.67 |
| 11 | TRIM67 | Tripartite motif containing 67 | 24.08 | No | No | No | 4.16 | 4.29 | 5.03 |
| 12 | MYCT1 | myc target 1myc target 1 | 21.26 | No | No | No | 0.74 | 2.90 | 7.66 |
| 13 | CD40LG | CD40 ligand | 14.12 | No | No | No | 6.65 | 11.57 | 16.69 |
| 14 | SCOC | Short coiled-coil protein | 13.45 | No | No | No | 0.97 | 0.79 | 1.04 |
| 15 | PPP1R16B | Protein phosphatase 1, regulatory subunit 16B | 13.18 | No | No | No | 0.70 | 1.83 | 1.15 |
| 19 | ACVR2A | Activin A receptor, type IIA | 9.45 | No | Yes | No | 0.15 | 0.42 | 0.67 |
| 26 | HHEX | Hematopoietically expressed homeobox | 6.87 | Yes | No | Yes | 0.66 | 1.44 | 0.89 |
| 37 | RUNX1 | runt-related transcription factor 1 | 5.46 | No | No | Yes | 5.02 | 1.25 | 1.12 |
| 41 | TAL1/SCL | T-cell acute lymphocytic leukemia 1 | 5.28 | No | Yes | Yes | 1.82 | 1.76 | 1.92 |
| 50 | EGFL7 | EGF-like-domain, multiple 7 | 4.69 | Yes | No | No | 0.67 | 2.11 | 1.92 |
| 69 | JUNB | jun B protooncogene | 3.78 | Yes | No | No | 3.50 | 3.87 | 3.24 |
ND indicates no data.